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This policy brief addresses the transition to the 2021 Optimal Formulary for pediatric antiretroviral drugs (ARVs) with the aim to enhance HIV treatment for children. It targets national governments, donors, and healthcare providers, emphasizing the importance of adopting dolutegravir (DTG)-based regimens for effective viral suppression in children. The document outlines strategies for transitioning to new drug formulations, addressing issues such as procurement, caregiver education, and healthcare worker training. It highlights the need for timely access to DTG regimens, considering their clinical benefits and the necessity for weight-based dosing adjustments. The brief supports the WHO's recommendations for optimizing pediatric ART regimens to improve health outcomes for infants and children living with HIV.

HIV-positive children. --- Antiretroviral agents.

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HIV infections --- HIV-positive children. --- HIV-positive youth. --- Treatment.

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AIDS (Disease) in children --- AIDS (Disease) in women --- AIDS (Disease) in infants --- HIV-positive children --- HIV-positive women --- Research --- Center for Research for Mothers and Children (U.S.).

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To improve survival and quality of life among the 2.5 million children living with HIV a comprehensive package of prevention care and treatment is required. This package should include management of infections such as pneumonia diarrhoea malaria and ear infections as well as common opportunistic infections and HIV-related co-morbidities. WHO is developing a series of guidelines on each of these conditions following the GRADE approach. The document on the management of pneumonia and diarrhoea in HIV-infected infants and children is the first of this series. The recommendations are similar to th

AIDS (Disease) -- Economic aspects. --- AIDS (Disease) -- Government policy. --- AIDS (Disease) -- Patients -- Services for. --- HIV-positive children --- HIV infections --- AIDS-related complex --- Diarrhea in children --- Pneumonia in children --- Child welfare --- Maternal and infant welfare --- Signs and Symptoms, Digestive --- Lung Diseases --- Age Groups --- Lentivirus Infections --- Immunologic Deficiency Syndromes --- Respiratory Tract Infections --- Sexually Transmitted Diseases, Viral --- Immune System Diseases --- Sexually Transmitted Diseases --- Persons --- Respiratory Tract Diseases --- Retroviridae Infections --- Signs and Symptoms --- Diseases --- Virus Diseases --- Pathological Conditions, Signs and Symptoms --- Named Groups --- RNA Virus Infections --- Pneumonia --- Diarrhea --- HIV Infections --- Infant --- Child --- Medicine --- Health & Biological Sciences --- Pediatrics --- Complications --- Treatment --- Research --- Effect of managed care on --- Child welfare. --- Maternal and infant welfare. --- Signs and Symptoms, Digestive. --- Lung Diseases. --- Age Groups. --- Lentivirus Infections. --- Immunologic Deficiency Syndromes. --- Respiratory Tract Infections. --- Sexually Transmitted Diseases, Viral. --- Immune System Diseases. --- Sexually Transmitted Diseases. --- Persons. --- Respiratory Tract Diseases. --- Retroviridae Infections. --- Signs and Symptoms. --- Disease. --- Virus Diseases. --- Pathological Conditions, Signs and Symptoms. --- RNA Virus Infections. --- Pneumonia. --- Diarrhea. --- HIV Infections. --- Infant. --- Child. --- Research. --- Complications. --- Treatment. --- Effect of managed care on.