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Identification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been developed into cancer biomarkers and targets. Multi-platforms for molecular characterization of tumors using next-generation genomic sequencing, immunohistochemistry, in situ hybridization, and blood-based biopsies have greatly expanded the portfolio of potential biomarkers and targets. These cancer biomarkers have been developed for diagnosis, early detection, prognosis, and prediction of treatment response. The molecular targets have been exploited for anti-cancer therapy and delivery of therapeutic agents. This Special Issue of Biomedicines focuses on recent advances in the discovery, characterization, translation, and clinical application of cancer biomarkers and targets in malignant diseases of the digestive system. The goal is to stimulate basic and translational research and clinical collaboration in this exciting field with the hope of developing strategies for prevention and early detection/diagnosis of cancer in digestive organs, and improving therapeutic and psychosocial outcomes in patients with these malignant diseases.
n/a --- liver graft injury --- HFE --- neurokinin --- chemotherapy --- intestinal tumors --- therapeutic targets --- biliary tract carcinoma --- hepatocellular carcinoma --- clinical trial --- cell adhesion molecules --- colorectal cancer --- biomarkers --- phenotypic mosaics --- gastrointestinal oncology --- Asian Cancer Research Group (ACRG) --- biomarker --- psychosocial support --- precision therapy --- pancreatic carcinoma --- precision medicine --- Liver transplantation --- predictive biomarkers --- CD274 --- cholecystokinin --- The Cancer Genome Atlas (TCGA) --- gastrin --- pembrolizumab --- immunotherapy --- gastrin-releasing peptide --- stereotactic body radiation therapy --- immunohistochemistry --- gastric carcinoma --- liver transplant --- CAM invasion assay --- intragraft gene expression profiles --- molecular profiling --- targeted therapy --- neurotensin --- intestinal disorder --- ramucirumab --- next-generation sequencing --- colorectal carcinoma --- tumor progenitor --- circulating tumor cells --- gastrointestinal malignancies --- bombesin --- trastuzumab --- somatostatin --- zebrafish --- G protein–coupled receptors --- G protein-coupled receptors
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Bladder cancer is the second most common genitourinary malignancy, with 81,190 estimated new diagnoses in 2018, in the United States alone. Transurethral resection of the bladder and radical cystectomy with bilateral pelvic lymph node dissection constitute the standard treatment for non-muscle invasive or very high-risk non-muscle invasive bladder cancer, respectively. However, survival expectations have not shown to improve in the last 20 years, and new diagnostic and therapeutic tools are urgently needed to improve the outcomes of this potentially lethal disease.
iron deficiency anemia --- fermented goat milk --- brain molecular functions --- neuroprotective effect --- iron supplementation --- pregnancy --- randomized controlled trial --- serum ferritin --- hemoglobin --- iron status --- iron stores --- HFE gene --- iron --- anemia --- kidney --- hepcidin --- erythropoietin --- celiac disease --- gluten-free diet --- iron deficiency --- micronutrient deficiencies --- infant --- breast milk --- formula milk --- high intensity exercise --- ubiquinol --- hematological parameters --- inflammation --- ergogenic effect --- acai --- erythropoiesis --- anaemia --- altitude adjustment --- haemoglobin --- South Africa --- women of reproductive age --- nutritional adequacy --- children --- fermented cow and goat milk --- iron homeostasis --- iron repletion --- gene and protein expression --- redox unbalance --- prematurity --- transfusion --- blood-sparing
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Bladder cancer is the second most common genitourinary malignancy, with 81,190 estimated new diagnoses in 2018, in the United States alone. Transurethral resection of the bladder and radical cystectomy with bilateral pelvic lymph node dissection constitute the standard treatment for non-muscle invasive or very high-risk non-muscle invasive bladder cancer, respectively. However, survival expectations have not shown to improve in the last 20 years, and new diagnostic and therapeutic tools are urgently needed to improve the outcomes of this potentially lethal disease.
Medicine --- iron deficiency anemia --- fermented goat milk --- brain molecular functions --- neuroprotective effect --- iron supplementation --- pregnancy --- randomized controlled trial --- serum ferritin --- hemoglobin --- iron status --- iron stores --- HFE gene --- iron --- anemia --- kidney --- hepcidin --- erythropoietin --- celiac disease --- gluten-free diet --- iron deficiency --- micronutrient deficiencies --- infant --- breast milk --- formula milk --- high intensity exercise --- ubiquinol --- hematological parameters --- inflammation --- ergogenic effect --- acai --- erythropoiesis --- anaemia --- altitude adjustment --- haemoglobin --- South Africa --- women of reproductive age --- nutritional adequacy --- children --- fermented cow and goat milk --- iron homeostasis --- iron repletion --- gene and protein expression --- redox unbalance --- prematurity --- transfusion --- blood-sparing --- iron deficiency anemia --- fermented goat milk --- brain molecular functions --- neuroprotective effect --- iron supplementation --- pregnancy --- randomized controlled trial --- serum ferritin --- hemoglobin --- iron status --- iron stores --- HFE gene --- iron --- anemia --- kidney --- hepcidin --- erythropoietin --- celiac disease --- gluten-free diet --- iron deficiency --- micronutrient deficiencies --- infant --- breast milk --- formula milk --- high intensity exercise --- ubiquinol --- hematological parameters --- inflammation --- ergogenic effect --- acai --- erythropoiesis --- anaemia --- altitude adjustment --- haemoglobin --- South Africa --- women of reproductive age --- nutritional adequacy --- children --- fermented cow and goat milk --- iron homeostasis --- iron repletion --- gene and protein expression --- redox unbalance --- prematurity --- transfusion --- blood-sparing
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In the current context of the electronic governance of society, both administrations and citizens are demanding greater participation of all the actors involved in the decision-making process relative to the governance of society. This book presents collective works published in the recent Special Issue (SI) entitled “Optimization for Decision Making”. These works give an appropriate response to the new challenges raised, the decision-making process can be done by applying different methods and tools, as well as using different objectives. In real-life problems, the formulation of decision-making problems and application of optimization techniques to support decisions are particularly complex and a wide range of optimization techniques and methodologies are used to minimize risks, improve quality in making decisions, or, in general, to solve problems. In addition, a sensitivity or robustness analysis should be done to validate/analyze the influence of uncertainty regarding decision-making. This book brings together a collection of inter-/multi-disciplinary works applied to the optimization for decision making in a coherent manner.
History of engineering & technology --- probabilistic dual hesitant fuzzy sets --- distance measures --- aggregation operators --- consumer behavior --- multi-criteria decision-making --- maximum deviation method --- Monorail --- urban transportation planning --- Analytic Network Process --- Technique for Order Preference by Similarity to Ideal Solution --- shift scheduling --- goal programming --- ANP --- natural gas combined cycle power plant --- energy sector --- Analytic Hierarchy Process (AHP) --- group decision making --- consistency --- compatibility --- multiple criteria group decision making (MCGDM) problems --- picture fuzzy sets (PFSs) --- picture 2-tuple linguistic numbers (P2TLNs) --- picture 2-tuple linguistic sets (P2TLSs) --- EDAS model --- green supplier selection --- human development --- internal security --- MCDM --- weight balancing --- WEBIRA --- cluster analysis --- homogeneous groups --- Bayesian analysis --- multiple attribute decision-making (MADM) --- q-rung orthopair fuzzy sets (q-ROFSs) --- cosine function --- cosine similarity measure --- pattern recognition --- scheme selection --- group decision-making --- hesitant fuzzy set --- interval-valued probability --- muirhead mean and programming model --- dual hesitant Pythagorean fuzzy sets (DHPFSs) --- dual hesitant Pythagorean fuzzy generalized weighted Heronian mean (DHPFGWHM) operator --- dual hesitant Pythagorean fuzzy generalized geometric weighted Heronian mean (DHPFGGWHM) operator --- supply chain management --- hesitant fuzzy element (HFE) --- Hamacher operations --- hesitant fuzzy Hamacher power-aggregation operators --- multiple-attribute decision-making (MADM) --- air traffic management --- work-shift scheduling problem --- variable neighborhood search --- performance analysis --- optimization --- decision-making --- MADM --- SAW --- COPRAS --- TOPSIS --- PROMETHEE --- MOORA --- normalization --- stability --- probabilistic dual hesitant fuzzy sets --- distance measures --- aggregation operators --- consumer behavior --- multi-criteria decision-making --- maximum deviation method --- Monorail --- urban transportation planning --- Analytic Network Process --- Technique for Order Preference by Similarity to Ideal Solution --- shift scheduling --- goal programming --- ANP --- natural gas combined cycle power plant --- energy sector --- Analytic Hierarchy Process (AHP) --- group decision making --- consistency --- compatibility --- multiple criteria group decision making (MCGDM) problems --- picture fuzzy sets (PFSs) --- picture 2-tuple linguistic numbers (P2TLNs) --- picture 2-tuple linguistic sets (P2TLSs) --- EDAS model --- green supplier selection --- human development --- internal security --- MCDM --- weight balancing --- WEBIRA --- cluster analysis --- homogeneous groups --- Bayesian analysis --- multiple attribute decision-making (MADM) --- q-rung orthopair fuzzy sets (q-ROFSs) --- cosine function --- cosine similarity measure --- pattern recognition --- scheme selection --- group decision-making --- hesitant fuzzy set --- interval-valued probability --- muirhead mean and programming model --- dual hesitant Pythagorean fuzzy sets (DHPFSs) --- dual hesitant Pythagorean fuzzy generalized weighted Heronian mean (DHPFGWHM) operator --- dual hesitant Pythagorean fuzzy generalized geometric weighted Heronian mean (DHPFGGWHM) operator --- supply chain management --- hesitant fuzzy element (HFE) --- Hamacher operations --- hesitant fuzzy Hamacher power-aggregation operators --- multiple-attribute decision-making (MADM) --- air traffic management --- work-shift scheduling problem --- variable neighborhood search --- performance analysis --- optimization --- decision-making --- MADM --- SAW --- COPRAS --- TOPSIS --- PROMETHEE --- MOORA --- normalization --- stability
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In the current context of the electronic governance of society, both administrations and citizens are demanding greater participation of all the actors involved in the decision-making process relative to the governance of society. This book presents collective works published in the recent Special Issue (SI) entitled “Optimization for Decision Making”. These works give an appropriate response to the new challenges raised, the decision-making process can be done by applying different methods and tools, as well as using different objectives. In real-life problems, the formulation of decision-making problems and application of optimization techniques to support decisions are particularly complex and a wide range of optimization techniques and methodologies are used to minimize risks, improve quality in making decisions, or, in general, to solve problems. In addition, a sensitivity or robustness analysis should be done to validate/analyze the influence of uncertainty regarding decision-making. This book brings together a collection of inter-/multi-disciplinary works applied to the optimization for decision making in a coherent manner.
History of engineering & technology --- probabilistic dual hesitant fuzzy sets --- distance measures --- aggregation operators --- consumer behavior --- multi-criteria decision-making --- maximum deviation method --- Monorail --- urban transportation planning --- Analytic Network Process --- Technique for Order Preference by Similarity to Ideal Solution --- shift scheduling --- goal programming --- ANP --- natural gas combined cycle power plant --- energy sector --- Analytic Hierarchy Process (AHP) --- group decision making --- consistency --- compatibility --- multiple criteria group decision making (MCGDM) problems --- picture fuzzy sets (PFSs) --- picture 2-tuple linguistic numbers (P2TLNs) --- picture 2-tuple linguistic sets (P2TLSs) --- EDAS model --- green supplier selection --- human development --- internal security --- MCDM --- weight balancing --- WEBIRA --- cluster analysis --- homogeneous groups --- Bayesian analysis --- multiple attribute decision-making (MADM) --- q-rung orthopair fuzzy sets (q-ROFSs) --- cosine function --- cosine similarity measure --- pattern recognition --- scheme selection --- group decision-making --- hesitant fuzzy set --- interval-valued probability --- muirhead mean and programming model --- dual hesitant Pythagorean fuzzy sets (DHPFSs) --- dual hesitant Pythagorean fuzzy generalized weighted Heronian mean (DHPFGWHM) operator --- dual hesitant Pythagorean fuzzy generalized geometric weighted Heronian mean (DHPFGGWHM) operator --- supply chain management --- hesitant fuzzy element (HFE) --- Hamacher operations --- hesitant fuzzy Hamacher power-aggregation operators --- multiple-attribute decision-making (MADM) --- air traffic management --- work-shift scheduling problem --- variable neighborhood search --- performance analysis --- optimization --- decision-making --- MADM --- SAW --- COPRAS --- TOPSIS --- PROMETHEE --- MOORA --- normalization --- stability
Choose an application
In the current context of the electronic governance of society, both administrations and citizens are demanding greater participation of all the actors involved in the decision-making process relative to the governance of society. This book presents collective works published in the recent Special Issue (SI) entitled “Optimization for Decision Making”. These works give an appropriate response to the new challenges raised, the decision-making process can be done by applying different methods and tools, as well as using different objectives. In real-life problems, the formulation of decision-making problems and application of optimization techniques to support decisions are particularly complex and a wide range of optimization techniques and methodologies are used to minimize risks, improve quality in making decisions, or, in general, to solve problems. In addition, a sensitivity or robustness analysis should be done to validate/analyze the influence of uncertainty regarding decision-making. This book brings together a collection of inter-/multi-disciplinary works applied to the optimization for decision making in a coherent manner.
probabilistic dual hesitant fuzzy sets --- distance measures --- aggregation operators --- consumer behavior --- multi-criteria decision-making --- maximum deviation method --- Monorail --- urban transportation planning --- Analytic Network Process --- Technique for Order Preference by Similarity to Ideal Solution --- shift scheduling --- goal programming --- ANP --- natural gas combined cycle power plant --- energy sector --- Analytic Hierarchy Process (AHP) --- group decision making --- consistency --- compatibility --- multiple criteria group decision making (MCGDM) problems --- picture fuzzy sets (PFSs) --- picture 2-tuple linguistic numbers (P2TLNs) --- picture 2-tuple linguistic sets (P2TLSs) --- EDAS model --- green supplier selection --- human development --- internal security --- MCDM --- weight balancing --- WEBIRA --- cluster analysis --- homogeneous groups --- Bayesian analysis --- multiple attribute decision-making (MADM) --- q-rung orthopair fuzzy sets (q-ROFSs) --- cosine function --- cosine similarity measure --- pattern recognition --- scheme selection --- group decision-making --- hesitant fuzzy set --- interval-valued probability --- muirhead mean and programming model --- dual hesitant Pythagorean fuzzy sets (DHPFSs) --- dual hesitant Pythagorean fuzzy generalized weighted Heronian mean (DHPFGWHM) operator --- dual hesitant Pythagorean fuzzy generalized geometric weighted Heronian mean (DHPFGGWHM) operator --- supply chain management --- hesitant fuzzy element (HFE) --- Hamacher operations --- hesitant fuzzy Hamacher power-aggregation operators --- multiple-attribute decision-making (MADM) --- air traffic management --- work-shift scheduling problem --- variable neighborhood search --- performance analysis --- optimization --- decision-making --- MADM --- SAW --- COPRAS --- TOPSIS --- PROMETHEE --- MOORA --- normalization --- stability
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