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Algae have been used since ancient times as food for humans, animal feed, agricultural fertilizer, and as a source of substances for therapeutic use. Currently, seaweed represents a vast source of raw materials used in the pharmaceutical, food, traditional medicine, and cosmetics industries. They are nutritionally valuable, both fresh and dried, or as ingredients in a wide variety of pre-made foods. In particular, seaweed contains significant amounts of protein, lipids, minerals, and vitamins. Information is limited on the role of algae and their metabolites in therapy. Only a few taxa have been studied for use in medicine. Many traditional cultures report the healing powers of selected algae in tropical and subtropical marine forms. This is especially true in the maritime areas of Asia, where the sea plays a significant role in daily activities. However, currently, only a few genera and species of algae are involved in aspects of medicine and therapy. The beneficial uses of seaweed or seaweed products include those that can mimic specific manifestations of human disease, production of antibiotic compounds, or improved human nutrition.
alginate --- minerals --- n/a --- edible seaweed --- macro algae --- Mycoplasma pneumoniae --- nutritional value --- seaweeds --- low molecular weight fucoidan --- osteoblast --- huBM-MSC --- ulvan --- HDL-C --- diffusion model --- adjuvant --- phlorotannin --- chlorophylls --- alkaline phosphatase --- raw laver --- heavy metals adsorption --- quantification --- colorectal cancer --- microbial risk --- processing technology --- anticoagulant activity --- isolation --- keratinocytes --- Black Sea --- Osmundea pinnatifida --- marine algae --- feed --- antigen-specific antibody --- bromophenols --- Ulva rigida --- carotenoids --- natural resources --- LDL-C --- functional substance --- agriculture --- particulate matter --- processed laver product --- reactive oxygen species --- health functionality --- cancer stem cells --- cytotoxicity --- HPLC --- omics-based technology --- Sargassum muticum --- TC reduction --- FTIR-ATR --- chemical risk --- enzymatic extracts --- n-3 PUFAs --- mono and polysaccharides --- health --- chemical sulfation --- food --- TC --- NMR --- TG --- carrageenan --- antitumour activity --- NK cell --- Cystoseira barbata --- EPA --- phlorofucofuroeckol A --- Ecklonia cava --- macroalgae/seaweed
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Mammalian ATP-binding cassette (ABC) transporters constitute a superfamily of proteins involved in many essential cellular processes. Most of these transporters are transmembrane proteins and allow the active transport of solutes, small molecules, and lipids across biological membranes. On the one hand, some of these transporters are involved in drug resistance (also referred to as MDR or multidrug resistance), a process known to be a major brake in most anticancer treatments, and the medical challenge is thus to specifically inhibit their function. On the other hand, molecular defects in some of these ABC transporters are correlated with several rare human diseases, the most well-documented of which being cystic fibrosis, which is caused by genetic variations in ABCC7/CFTR (cystic fibrosis transmembrane conductance regulator). In the latter case, the goal is to rescue the function of the deficient transporters using various means, such as targeted pharmacotherapies and cell or gene therapy. The aim of this Special Issue, “ABC Transporters in Human Diseases”, is to present, through original articles and reviews, the state-of-the-art of our current knowledge about the role of ABC transporters in human diseases and the proposed therapeutic options based on studies ranging from cell and animal models to patients.
ABC transporters --- drug action --- regulatory extension --- regulatory insertion --- mechanism of action --- MRP1 --- MRP4 --- breast cancer --- proliferation --- migration --- invasion --- cAMP --- ABCG2 --- ABCB1 --- blood-brain barrier --- PET --- Alzheimer’s disease --- beta-amyloid --- tariquidar --- erlotinib --- ABCG5 --- ABCG8 --- ATP-binding cassette transporter --- cholesterol --- polar relay --- sitosterolemia --- 5′ untranslated region --- cis-acting elements --- ABCA subfamily --- bioinformatics --- ABC transporter --- therapy response --- disease-free survival --- next-generation sequencing --- competitive allele-specific PCR --- P-glycoprotein --- amyloid-beta --- neuron --- SK-N-SH --- gene therapy --- AAV --- PFIC --- BSEP --- ABCB11 --- bile salts --- intrahepatic cholestasis --- chaperones --- PFIC2 --- BRIC --- ATP-binding cassette transporter A1 (ABCA1) --- cholesterol homeostasis --- reverse cholesterol transport --- HDL-C --- dyslipidemia --- type 2 diabetes --- microparticles --- ABCG2 genotype --- clinico-genetic analysis --- ethnic specificity --- genetic variations --- precision medicine --- rare variant --- Roma --- serum uric acid --- SUA-lowering therapy --- urate transporter --- bile secretion --- ABCB4 --- ABCC2 --- ABCG5/G8 --- molecular partners --- phytosterol --- xenosterol --- atherosclerosis --- gall stone --- ABC --- transporter --- ABC (ATP-binding cassette) transporters --- multidrug resistance --- transport --- trafficking --- urate --- mutations --- polymorphisms --- ABCC6 --- TNAP --- NT5E --- Pseudoxanthoma elasticum (PXE) --- cancer --- membrane protein --- functional divergence --- calcification --- pseudoxanthoma elasticum --- generalized arterial calcification of infancy --- pyrophosphate --- therapies --- ABCA7 --- phagocytosis --- Aβ peptides --- yeast --- multidrug transporter --- anticancer --- antifungal resistance --- mechanism --- peroxisome --- adrenoleukodystrophy --- fatty acids --- gout --- early-onset gout --- hyperuricemia --- uric acid --- BCRP --- single nucleotide polymorphism --- SNP --- homology modeling --- substrate-binding site --- cellular ATP efflux --- mutagenesis --- intracellular traffic --- MDR3 --- phosphatidylcholine --- RAB GTPase --- taxol --- drug transport --- n/a --- Alzheimer's disease --- 5' untranslated region
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Several lines of evidence indicate that healthy diet and exercise can prevent cardiovascular diseases, stroke, diabetes, and some types of cancer such as colon cancer, and smoking-related cancers. Dietary patterns defined as the quantities, proportions, variety, or combination of different foods and drinks, and the frequency with which they are habitually consumed are also associated with an increased or decreased incidence of chronic diseases. Lately, an association has been found between eating habits, exercise, and psychological and/or mental disorders. This Special Issue of Nutrients, entitled “Dietary Habits, Beneficial Exercise, and Chronic Diseases: Latest Advances and Prospects”, contains 20 manuscripts, either describing original research or reviewing the scientific literature, focused on the relationship between dietary habits (macronutrients, micronutrients, etc.) and/or exercise with metabolic, cardiovascular, neurological, mental, rheumatic, inflammatory, gastrointestinal, odontostomatological, and other chronic diseases.
muscle wasting --- cachexia --- sarcopenia --- probiotics --- prebiotics --- Lactobacillus --- intestinal permeability --- gut–brain axis --- health literacy --- education --- food --- students --- healthy lifestyle --- β-hydroxybutyrate (BHB) --- body mass index (BMI), type 1 diabetes --- type 2 diabetes (T2D) --- hemoglobin A1c (HbA1c) --- visceral adipose tissue (VAT) --- cardiovascular disease (CVD) --- high-density lipoprotein (HDL) --- low-density lipoprotein (LDL) --- Apolipoprotein B (ApoB) --- women’s health --- bone mineral density --- diet --- beach sports --- osteoporosis --- Mediterranean diet --- antioxidation --- metabolic health --- reproductive health --- gut microbiota --- non-communicable diseases --- flavonoids --- polyphenols --- resveratrol --- olive oil --- adult volunteers --- dietary intervention --- dietary patterns --- pilot study --- symbiotic agriculture --- metabolic dysfunction --- metabolic syndrome --- metabolome --- EHIS --- diabetes --- disease burden --- European Union --- policies --- dietary trajectories --- overweight --- obesity --- early childhood caries --- ECC --- dental caries --- health risk --- preschool children --- fish protein hydrolysate --- anxiety --- burying test --- rodent --- perceived stress --- psychological --- stress --- diet quality --- women --- reproductive age --- childbearing age --- a-priori --- a-posteriori --- sodium --- sodium intake --- inflammation --- systemic inflammation --- sodium induced inflammation --- CRP --- TNF-a --- IL-6 --- pediatric obesity --- children --- dietary interventions --- prevention --- pure fructose consumption --- adolescent --- blood pressure --- folic acid --- homocysteine --- inflammatory bowel disease --- microbiota --- crocin --- crocetin --- safranal --- effect direction plot --- complementary and alternative medicine --- medicinal plant --- CAM --- herbal medicine --- TNF-α --- qualitative synthesis --- dietary supplements --- food shopping quality indicators --- FSA-NPS DI --- dietary intake --- diet monitoring --- digital receipts --- dietary quality --- ischemic stroke --- Chinese Diet Balance Index 2016 --- DBI-16 --- Southeast China --- bone density --- bone resorption markers --- HDL-C --- LDL-C --- lipid profile --- cardiovascular disease --- exercise --- aerobic fitness --- multiple sclerosis --- nutrition --- physical activity --- body mass index --- dietary guideline --- reproductive age women --- n/a --- gut-brain axis --- women's health
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Mammalian ATP-binding cassette (ABC) transporters constitute a superfamily of proteins involved in many essential cellular processes. Most of these transporters are transmembrane proteins and allow the active transport of solutes, small molecules, and lipids across biological membranes. On the one hand, some of these transporters are involved in drug resistance (also referred to as MDR or multidrug resistance), a process known to be a major brake in most anticancer treatments, and the medical challenge is thus to specifically inhibit their function. On the other hand, molecular defects in some of these ABC transporters are correlated with several rare human diseases, the most well-documented of which being cystic fibrosis, which is caused by genetic variations in ABCC7/CFTR (cystic fibrosis transmembrane conductance regulator). In the latter case, the goal is to rescue the function of the deficient transporters using various means, such as targeted pharmacotherapies and cell or gene therapy. The aim of this Special Issue, “ABC Transporters in Human Diseases”, is to present, through original articles and reviews, the state-of-the-art of our current knowledge about the role of ABC transporters in human diseases and the proposed therapeutic options based on studies ranging from cell and animal models to patients.
Research & information: general --- Biology, life sciences --- ABC transporters --- drug action --- regulatory extension --- regulatory insertion --- mechanism of action --- MRP1 --- MRP4 --- breast cancer --- proliferation --- migration --- invasion --- cAMP --- ABCG2 --- ABCB1 --- blood-brain barrier --- PET --- Alzheimer's disease --- beta-amyloid --- tariquidar --- erlotinib --- ABCG5 --- ABCG8 --- ATP-binding cassette transporter --- cholesterol --- polar relay --- sitosterolemia --- 5' untranslated region --- cis-acting elements --- ABCA subfamily --- bioinformatics --- ABC transporter --- therapy response --- disease-free survival --- next-generation sequencing --- competitive allele-specific PCR --- P-glycoprotein --- amyloid-beta --- neuron --- SK-N-SH --- gene therapy --- AAV --- PFIC --- BSEP --- ABCB11 --- bile salts --- intrahepatic cholestasis --- chaperones --- PFIC2 --- BRIC --- ATP-binding cassette transporter A1 (ABCA1) --- cholesterol homeostasis --- reverse cholesterol transport --- HDL-C --- dyslipidemia --- type 2 diabetes --- microparticles --- ABCG2 genotype --- clinico-genetic analysis --- ethnic specificity --- genetic variations --- precision medicine --- rare variant --- Roma --- serum uric acid --- SUA-lowering therapy --- urate transporter --- bile secretion --- ABCB4 --- ABCC2 --- ABCG5/G8 --- molecular partners --- phytosterol --- xenosterol --- atherosclerosis --- gall stone --- ABC --- transporter --- ABC (ATP-binding cassette) transporters --- multidrug resistance --- transport --- trafficking --- urate --- mutations --- polymorphisms --- ABCC6 --- TNAP --- NT5E --- Pseudoxanthoma elasticum (PXE) --- cancer --- membrane protein --- functional divergence --- calcification --- pseudoxanthoma elasticum --- generalized arterial calcification of infancy --- pyrophosphate --- therapies --- ABCA7 --- phagocytosis --- Aβ peptides --- yeast --- multidrug transporter --- anticancer --- antifungal resistance --- mechanism --- peroxisome --- adrenoleukodystrophy --- fatty acids --- gout --- early-onset gout --- hyperuricemia --- uric acid --- BCRP --- single nucleotide polymorphism --- SNP --- homology modeling --- substrate-binding site --- cellular ATP efflux --- mutagenesis --- intracellular traffic --- MDR3 --- phosphatidylcholine --- RAB GTPase --- taxol --- drug transport
Choose an application
Several lines of evidence indicate that healthy diet and exercise can prevent cardiovascular diseases, stroke, diabetes, and some types of cancer such as colon cancer, and smoking-related cancers. Dietary patterns defined as the quantities, proportions, variety, or combination of different foods and drinks, and the frequency with which they are habitually consumed are also associated with an increased or decreased incidence of chronic diseases. Lately, an association has been found between eating habits, exercise, and psychological and/or mental disorders. This Special Issue of Nutrients, entitled “Dietary Habits, Beneficial Exercise, and Chronic Diseases: Latest Advances and Prospects”, contains 20 manuscripts, either describing original research or reviewing the scientific literature, focused on the relationship between dietary habits (macronutrients, micronutrients, etc.) and/or exercise with metabolic, cardiovascular, neurological, mental, rheumatic, inflammatory, gastrointestinal, odontostomatological, and other chronic diseases.
Research & information: general --- Biology, life sciences --- Food & society --- muscle wasting --- cachexia --- sarcopenia --- probiotics --- prebiotics --- Lactobacillus --- intestinal permeability --- gut-brain axis --- health literacy --- education --- food --- students --- healthy lifestyle --- β-hydroxybutyrate (BHB) --- body mass index (BMI), type 1 diabetes --- type 2 diabetes (T2D) --- hemoglobin A1c (HbA1c) --- visceral adipose tissue (VAT) --- cardiovascular disease (CVD) --- high-density lipoprotein (HDL) --- low-density lipoprotein (LDL) --- Apolipoprotein B (ApoB) --- women's health --- bone mineral density --- diet --- beach sports --- osteoporosis --- Mediterranean diet --- antioxidation --- metabolic health --- reproductive health --- gut microbiota --- non-communicable diseases --- flavonoids --- polyphenols --- resveratrol --- olive oil --- adult volunteers --- dietary intervention --- dietary patterns --- pilot study --- symbiotic agriculture --- metabolic dysfunction --- metabolic syndrome --- metabolome --- EHIS --- diabetes --- disease burden --- European Union --- policies --- dietary trajectories --- overweight --- obesity --- early childhood caries --- ECC --- dental caries --- health risk --- preschool children --- fish protein hydrolysate --- anxiety --- burying test --- rodent --- perceived stress --- psychological --- stress --- diet quality --- women --- reproductive age --- childbearing age --- a-priori --- a-posteriori --- sodium --- sodium intake --- inflammation --- systemic inflammation --- sodium induced inflammation --- CRP --- TNF-a --- IL-6 --- pediatric obesity --- children --- dietary interventions --- prevention --- pure fructose consumption --- adolescent --- blood pressure --- folic acid --- homocysteine --- inflammatory bowel disease --- microbiota --- crocin --- crocetin --- safranal --- effect direction plot --- complementary and alternative medicine --- medicinal plant --- CAM --- herbal medicine --- TNF-α --- qualitative synthesis --- dietary supplements --- food shopping quality indicators --- FSA-NPS DI --- dietary intake --- diet monitoring --- digital receipts --- dietary quality --- ischemic stroke --- Chinese Diet Balance Index 2016 --- DBI-16 --- Southeast China --- bone density --- bone resorption markers --- HDL-C --- LDL-C --- lipid profile --- cardiovascular disease --- exercise --- aerobic fitness --- multiple sclerosis --- nutrition --- physical activity --- body mass index --- dietary guideline --- reproductive age women
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