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Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation.

Cell adhesion molecules. --- Cell receptors. --- G proteins. --- Guanyl cyclase. --- G proteins --- Cell receptors --- Cell adhesion molecules --- Biology --- Receptors, Cell Surface --- Antigens, Differentiation --- Biological Science Disciplines --- Natural Science Disciplines --- Membrane Proteins --- Antigens, Surface --- Biological Markers --- Biological Factors --- Antigens --- Disciplines and Occupations --- Proteins --- Chemicals and Drugs --- Amino Acids, Peptides, and Proteins --- Physiology --- Antigens, CD --- Genetics --- Receptors, G-Protein-Coupled --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Adhesion molecules (Cytology) --- Adhesion substances (Cytology) --- Cell adhesion substances --- Intercellular adhesion molecules --- Morphoregulatory molecules --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- GTP-binding proteins --- GTP regulatory proteins --- Guanine nucleotide-binding proteins --- Guanine nucleotide regulatory proteins --- Medicine. --- Human physiology. --- Molecular biology. --- Biomedicine. --- Human Physiology. --- Biomedicine general. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Human biology --- Medical sciences --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Binding sites (Biochemistry) --- Cell membranes --- Membrane proteins --- Desmosomes --- Hemidesmosomes --- Health Workforce --- Biomedicine, general.