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Small GTPases in disease.
Authors: --- ---
ISBN: 0123739683 9786611308711 1281308714 0080877605 Year: 2008 Publisher: Amsterdam : Academic Press/Elsevier,

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Abstract

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences. Methods in Enzymology is now available online at ScienceDirect - full-text online of volumes 1 onw


Periodical
Small GTPases.
ISSN: 21541256 21541248 Year: 2010 Publisher: Austin, TX : Philadelphia, PA : Landes Bioscience, Taylor & Francis

Regulators and effectors of small GTPases : Ras family
Authors: --- ---
ISSN: 00766879 ISBN: 0121828123 9780121828127 9786610635818 1280635819 0080463592 Year: 2006 Volume: 407 Publisher: Amsterdam ; Boston : Elsevier/Academic Press,

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The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continua

Small GTPases in disease
Authors: --- ---
ISBN: 0123743117 9786611279462 1281279463 0080570070 9780123743114 0123739683 9780123739681 Year: 2008 Publisher: Amsterdam ; London : Academic,

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Abstract

The critically acclaimed laboratory standard for more than 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences. Methods in Enzymology is now available online at ScienceDirect - full-text online of volume 1

Ras family GTPases
Author:
ISBN: 1280852097 9786610852093 1402047088 1402043287 Year: 2006 Publisher: Dordrecht ; [London] : Springer,

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Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. First, their frequent mutational activation in human cancers establishes Ras proteins as important mediators of oncogenesis and targets for anti-cancer drug discovery. Second, Ras proteins act as signalling nodes activated by diverse extracellular stimuli, and activated Ras in turn regulates a diversity of cytoplasmic signalling networks. Third, Ras proteins are founding members of a large superfamily of Ras-related small GTPases. Over 150 Ras-related small GTPases are found in the human genome, with orthologs found in all vertebrate species and invertebrates. This book features chapters by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.

GTPases in biology
Authors: ---
ISBN: 0387567739 3540567739 3540569375 3642782698 3642782671 3642783473 3642783457 Year: 1993 Volume: 108 Publisher: Berlin ; Heidelberg ; London Springer

Regulators and effectors of small GTPases : Rho family
Authors: --- ---
ISSN: 00766879 ISBN: 0121828115 9780121828110 9786611050368 1281050369 0080479391 Year: 2006 Volume: 406 Publisher: Amsterdam ; Boston : Elsevier : Academic Press,

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Abstract

The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continua

Small GTPases and their regulators. Part B : Rho family
Authors: --- ---
ISBN: 0121821560 0121821579 0121821587 9780121821562 9780121821586 9780121821579 Year: 1995 Volume: 255-256-257 Publisher: New York, NY : Academic Press,

Arf family gtpases
Author:
ISBN: 1402025939 1402017197 Year: 2003 Publisher: Dordrecht, Netherlands ; Boston, Massachusetts : Kluwer Academic Publishers,

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For the first time experts in the area of signalling research with a focus on the ARF family have contributed to the production of a title devoted to ARF biology. A comprehensive phylogenetic analysis of the ARF family, tables of the ARF GEFs and ARF GAPs, and more than a dozen chapters describing them in detail are provided. The impact of the ARF proteins on widely diverse aspects of cell biology and cell signalling can be clearly seen from the activities described; including membrane traffic, lipid metabolism, receptor desensitization, mouse development, microtubule dynamics, and bacterial pathogenesis. Anyone interested in understanding the complexities of cell signalling and the integration of signalling networks will benefit from this volume.


Book
GTPases : Versatile Regulators of Signal Transduction in Plants
Authors: --- --- ---
ISBN: 9783319116112 331911610X 9783319116105 3319116118 Year: 2015 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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G proteins are the key regulators for a wide range of cellular processes in animals and plants. In comparison to animals and yeast, plants have a single Rho-GTPase subfamily called Rho-like GTPases (ROPs). The ROP family of monomeric GTPases has emerged as a versatile and key regulator in plant signal transduction processes. During the past few years’ studies on plant RHO-type (ROP) GTPase have generated new insights into their role in diverse processes ranging from cytoskeletal organization, polar growth, development to stress and hormonal responses.  Studies have shown that plants have evolved specific regulators and effector molecules. ROP GTPases possess the ability to interact with these multiple regulator and effector molecules that ultimately determines their signaling specificity. Recently, genome wide studies in plants have shown that the Arabidopsis genome encodes 93, and rice has nearly 85 small GTPase homologs. And we have been able to identify four new homologs in the rice genome. Here, we focus on the complete phylogenetic, domain, structural and expression analysis during stress and various developmental processes of small GTPases in plants. The comparison of gene expression patterns of the individual members of the GTPase family may help to reveal potential plant specific signaling mechanisms and their relevance. Also, we are summarizing the role of currently known ROP GTPases and their interacting proteins with brief description, simultaneously, comparing their expression pattern based on microarray data. Overall, we will be discussing the functional genomic perspective of plant Rho like GTPases and their role in regulating several physiological processes such as stress, hormonal, pollen tube, root hair-growth and other developmental responses.

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