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Book
Biomolecular Interfaces : Interactions, Functions and Drug Design
Author:
ISBN: 9783319168500 3319168495 9783319168494 3319168509 Year: 2015 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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Abstract

The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior. The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and biomolecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.

Keywords

Life Sciences. --- Protein-Ligand Interactions. --- Membrane Biology. --- Molecular Medicine. --- Pharmaceutical Sciences/Technology. --- Biophysics and Biological Physics. --- Life sciences. --- Medicine. --- Pharmaceutical technology. --- RNA-ligand interactions. --- Cell membranes. --- Sciences de la vie --- Médecine --- Techniques pharmaceutiques --- Membrane cellulaire --- Antigens, Surface --- Membrane Glycoproteins --- Drug Therapy --- Drug Discovery --- Cell Physiological Processes --- Proteins --- Glycoproteins --- Chemistry, Pharmaceutical --- Amino Acids, Peptides, and Proteins --- Antigens --- Investigative Techniques --- Therapeutics --- Cell Physiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemistry --- Chemicals and Drugs --- Pharmacology --- Biological Factors --- Phenomena and Processes --- Natural Science Disciplines --- Biological Science Disciplines --- Disciplines and Occupations --- Cell Adhesion Molecules --- Drug Design --- Cell Adhesion --- Drug Delivery Systems --- Membrane Proteins --- Physical Sciences & Mathematics --- Biochemistry --- Integral Membrane Protein --- Membrane Protein --- Membrane-Associated Proteins --- Cell Membrane Proteins --- Cell Surface Proteins --- Integral Membrane Proteins --- Surface Proteins --- Membrane Associated Proteins --- Membrane Protein, Integral --- Membrane Proteins, Integral --- Protein, Integral Membrane --- Protein, Membrane --- Proteins, Cell Membrane --- Proteins, Cell Surface --- Proteins, Integral Membrane --- Proteins, Membrane --- Proteins, Membrane-Associated --- Proteins, Surface --- Drug Targeting --- Delivery System, Drug --- Delivery Systems, Drug --- Drug Delivery System --- Drug Targetings --- System, Drug Delivery --- Systems, Drug Delivery --- Targeting, Drug --- Targetings, Drug --- Adhesion, Cell --- Adhesions, Cell --- Cell Adhesions --- Drug Modeling --- Design, Drug --- Designs, Drug --- Drug Designs --- Drug Modelings --- Modeling, Drug --- Modelings, Drug --- Saccharide Mediated Cell Adhesion Molecules --- Intercellular Adhesion Molecules --- Leukocyte Adhesion Molecules --- Saccharide-Mediated Cell Adhesion Molecules --- Adhesion Molecules, Cell --- Adhesion Molecules, Intercellular --- Adhesion Molecules, Leukocyte --- Molecules, Cell Adhesion --- Molecules, Intercellular Adhesion --- Molecules, Leukocyte Adhesion --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Biologic Agents --- Biologic Factors --- Biological Factor --- Factor, Biologic --- Factor, Biological --- Factors, Biological --- Biological Agents --- Agents, Biologic --- Agents, Biological --- Biologic Factor --- Factors, Biologic --- Pharmacologies --- Pharmaceutical Preparations --- Cell Physiological Phenomenon --- Cell Physiological Process --- Physiology, Cell --- Cell Physiology --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Cells --- Therapy --- Treatment --- Therapeutic --- Therapies --- Treatments --- Disease --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Antigen --- Chemistry, Pharmaceutic --- Pharmaceutic Chemistry --- Pharmaceutical Chemistry --- Medicinal Chemistry --- Chemistry, Medicinal --- Glycoprotein --- Neoglycoproteins --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Drug Prospecting --- Discovery, Drug --- Prospecting, Drug --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Cell Surface Glycoprotein --- Membrane Glycoprotein --- Surface Glycoprotein --- Cell Surface Glycoproteins --- Surface Glycoproteins --- Glycoprotein, Cell Surface --- Glycoprotein, Membrane --- Glycoprotein, Surface --- Glycoproteins, Cell Surface --- Glycoproteins, Membrane --- Glycoproteins, Surface --- Surface Glycoprotein, Cell --- Surface Glycoproteins, Cell --- Cell Surface Antigen --- Immunologic Surface Markers --- Markers, Immunological Surface --- Surface Antigen --- Surface Markers, Immunologic --- Cell Surface Antigens --- Surface Antigens --- Surface Markers, Immunological --- Antigen, Cell Surface --- Antigen, Surface --- Antigens, Cell Surface --- Immunological Surface Markers --- Markers, Immunologic Surface --- Surface Antigen, Cell --- Surface Antigens, Cell --- pharmacology --- physiology --- therapy --- drug therapy --- therapeutic use --- Molecular biology. --- Proteins. --- Biophysics. --- Biological physics. --- Biological and Medical Physics, Biophysics. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomolecules. --- Proteins . --- Cell membranes . --- Biological physics --- Biology --- Physics --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology --- Proteids --- Polypeptides --- Proteomics

G Ptrotein pathways : Part C: effector mechanisms.
Authors: ---
ISBN: 1281011223 9786611011222 0080496938 012182246X Year: 2002 Publisher: New York (N.Y.) Academic press

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Abstract

This third volume in the trio covering G proteins, features integrated approaches to studying G proteins. Methods pertaining to signaling mechanisms are presented, including theoretical and modeling approaches, biochemistry and molecular biology, and cell biology and physiology. The techniques for studying the structure and function of G proteins are important not only to those with specific research interests in them, but also endocrinologists and pharmacologists conducting research on signaling mechanisms that are increasingly understood to interact with G proteins.

Keywords

Cell adhesion molecules. --- Cell receptors. --- G proteins. --- Membrane Glycoproteins --- Biochemical Processes --- Membrane Transport Proteins --- Enzymes and Coenzymes --- Cell Physiological Processes --- Carrier Proteins --- GTP Phosphohydrolases --- Intracellular Signaling Peptides and Proteins --- Membrane Proteins --- Cell Physiological Phenomena --- Proteins --- Biochemical Phenomena --- Chemicals and Drugs --- Peptides --- Chemical Processes --- Acid Anhydride Hydrolases --- Amino Acids, Peptides, and Proteins --- Chemical Phenomena --- Phenomena and Processes --- Hydrolases --- GTP-Binding Proteins --- Heterotrimeric GTP-Binding Proteins --- Ion Channels --- Enzymes --- Signal Transduction --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Biocatalysts --- Ion Channel --- Ionic Channel --- Ionic Channels --- Membrane Channel --- Membrane Channels --- Channel, Ion --- Channel, Ionic --- Channel, Membrane --- Channels, Ion --- Channels, Ionic --- Channels, Membrane --- Heterotrimeric G-Proteins --- G-Proteins, Heterotrimeric --- GTP-Binding Proteins, Heterotrimeric --- Heterotrimeric G Proteins --- Heterotrimeric GTP Binding Proteins --- G-Protein --- GTP-Binding Protein --- GTP-Regulatory Protein --- Guanine Nucleotide Coupling Protein --- G-Proteins --- GTP-Regulatory Proteins --- Guanine Nucleotide Regulatory Proteins --- G Protein --- G Proteins --- GTP Binding Protein --- GTP Binding Proteins --- GTP Regulatory Protein --- GTP Regulatory Proteins --- Protein, GTP-Binding --- Protein, GTP-Regulatory --- Proteins, GTP-Binding --- Proteins, GTP-Regulatory --- Chemical Phenomenon --- Chemical Process --- Physical Chemistry Phenomena --- Physical Chemistry Process --- Physicochemical Phenomenon --- Physicochemical Process --- Chemical Concepts --- Physical Chemistry Concepts --- Physical Chemistry Processes --- Physicochemical Concepts --- Physicochemical Phenomena --- Physicochemical Processes --- Chemical Concept --- Chemistry Process, Physical --- Chemistry Processes, Physical --- Concept, Chemical --- Concept, Physical Chemistry --- Concept, Physicochemical --- Concepts, Chemical --- Concepts, Physical Chemistry --- Concepts, Physicochemical --- Phenomena, Chemical --- Phenomena, Physical Chemistry --- Phenomena, Physicochemical --- Phenomenon, Chemical --- Phenomenon, Physicochemical --- Physical Chemistry Concept --- Physicochemical Concept --- Process, Chemical --- Process, Physical Chemistry --- Process, Physicochemical --- Processes, Chemical --- Processes, Physical Chemistry --- Processes, Physicochemical --- Polypeptides --- Biochemical Concepts --- Biochemical Phenomenon --- Biochemical Process --- Phenomena, Biochemical --- Biochemical Concept --- Concept, Biochemical --- Concepts, Biochemical --- Phenomenon, Biochemical --- Process, Biochemical --- Processes, Biochemical --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Cell Physiological Phenomenon --- Cell Physiological Process --- Physiology, Cell --- Cell Physiology --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Cells --- Integral Membrane Protein --- Membrane Protein --- Membrane-Associated Proteins --- Cell Membrane Proteins --- Cell Surface Proteins --- Integral Membrane Proteins --- Surface Proteins --- Membrane Associated Proteins --- Membrane Protein, Integral --- Membrane Proteins, Integral --- Protein, Integral Membrane --- Protein, Membrane --- Proteins, Cell Membrane --- Proteins, Cell Surface --- Proteins, Integral Membrane --- Proteins, Membrane --- Proteins, Membrane-Associated --- Proteins, Surface --- Intracellular Signaling Peptides --- Intracellular Signaling Proteins --- Peptides, Intracellular Signaling --- Proteins, Intracellular Signaling --- Signaling Peptides, Intracellular --- Signaling Proteins, Intracellular --- GTP Phosphohydrolase --- GTPase --- GTPases --- Guanosine Triphosphate Phosphohydrolases --- Guanosinetriphosphatases --- Phosphohydrolase, GTP --- Phosphohydrolases, GTP --- Phosphohydrolases, Guanosine Triphosphate --- Triphosphate Phosphohydrolases, Guanosine --- Binding Protein --- Binding Proteins --- Transport Proteins --- Protein, Binding --- Proteins, Binding --- Proteins, Carrier --- Proteins, Transport --- Coenzymes and Enzymes --- Cell Surface Glycoprotein --- Membrane Glycoprotein --- Surface Glycoprotein --- Cell Surface Glycoproteins --- Surface Glycoproteins --- Glycoprotein, Cell Surface --- Glycoprotein, Membrane --- Glycoprotein, Surface --- Glycoproteins, Cell Surface --- Glycoproteins, Membrane --- Glycoproteins, Surface --- Surface Glycoprotein, Cell --- Surface Glycoproteins, Cell --- Biological Pumps --- Metabolic Pumps --- Permeases --- Pump, Biologic --- Pump, Biological --- Pump, Metabolic --- Pumps, Biological --- Pumps, Metabolic --- Biological Pump --- Membrane Transporters --- Metabolic Pump --- Biologic Pump --- Transport Proteins, Membrane --- Transporters, Membrane --- physiology --- Anhydride Hydrolases, Acid --- Hydrolases, Acid Anhydride --- Cell Signaling --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Molecular Mechanisms of Pharmacological Action --- Molecular Biology --- Cell Membrane --- Membranes --- Protein Binding --- Receptors, Transferrin --- Protein Translocation Systems --- Biological Transport --- Bacterial Secretion Systems --- Biocatalyst --- Enzyme --- Heterotrimeric G Protein --- G Protein, Heterotrimeric --- Protein, Heterotrimeric G --- Hydrolase --- Peptide --- Polypeptide --- Protein --- Cell Membrane Protein --- Cell Surface Protein --- Membrane-Associated Protein --- Surface Protein --- Membrane Associated Protein --- Membrane Protein, Cell --- Protein, Cell Membrane --- Protein, Cell Surface --- Protein, Membrane-Associated --- Protein, Surface --- Surface Protein, Cell --- Carrier Protein --- Transport Protein --- Protein, Carrier --- Protein, Transport --- Membrane Transport Protein --- Membrane Transporter --- Permease --- Protein, Membrane Transport --- Transport Protein, Membrane --- Transporter, Membrane --- Gtp-binding proteins --- Signal transduction --- Membrane proteins.

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