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This volume provides a comprehensive overview of recent advances in targeting glutamate signaling for the treatment of major psychiatric and neurological disorders. It draws on the latest findings in glutamate neurobiology and offers valuable insights into the application of translational principles in neuroscience drug discovery and development. In each chapter, glutamate as a neurotransmitter, its receptors and transporters, and their interplay with other neurotransmitters and neurotrophic factors, are discussed in the context of a specific, highly prevalent and disabling CNS disease. Most recent and detailed information is provided on Ischemic Stroke, Chronic Stress, Major Depressive Disorder, Bipolar Disorder, Autism Spectrum Disorders (ASD), Posttraumatic Stress Disorder (PTSD), Alzheimer's Dementia, Schizophrenia, Impulsive Aggression, Substance Use Disorders (SUD), Amyotrophic Lateral Sclerosis (ALS), Chronic Pain, Multiple Sclerosis, Parkinson's Disease, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Epilepsy and Anxiety disorders. Moreover, the book includes an extensive overview of glutamatergic treatments already available on the market, and those which are currently in pharmaceutical drug development pipelines. The primary beneficiaries will be neurology and psychiatry specialists and residents, neuroscientists, neuropharmacologists, pharmaceutical industry and clinical research organization professionals, academics, and clinicians working with psychiatric and neurological patients with comorbidities such as cardiologists, pulmonologists, and endocrinologists. This book will also appeal to psychiatry and neurology subspecialists and clinicians working in neuroscience labs seeking an easy-to-understand yet comprehensive overview of contemporary evidence-based clinical insights backed by basic science (preclinical) research evidence. Given its scope, the book is also a unique and indispensable resource for both preclinical and clinical neuroscientists, medical advisors, and clinical research specialists in the pharmaceutical industry. In addition, it will appeal to neuroscience and neuropsychopharmacology students and guide them through the complexities of glutamate involvement in the pathophysiology of the most common debilitating brain diseases with high unmet medical needs.

Psychology --- History of human medicine --- Psychiatry --- Neuropathology --- neurologie --- psychiatrie --- farmacologie --- hersenen --- neuropsychologie --- Neural transmission. --- Glutamina --- Neurotransmissió --- Trastorns de la conducta

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Amino acids --- Amino Acids. --- Amino acids. --- Acids, Amino --- Amino compounds --- Organic acids --- Peptides --- aminozuren --- Biochemistry --- Amino Acid --- Acid, Amino --- Bioquímica. --- Aminoàcids. --- Àcids aminats --- Àcid glutàmic --- Aminoàcids essencials --- Aminoàcids sulfurosos --- Cisteïna --- Glutamina --- Protamines --- Química biològica --- Química fisiològica --- Biologia --- Medicina --- Química --- Absorció (Fisiologia) --- Anàlisi enzimàtica --- Biodegradació --- Biodisponibilitat --- Bioelectroquímica --- Bioenergètica --- Biogeoquímica --- Biologia molecular --- Bioquímica analítica --- Bioquímica clínica --- Bioquímica física --- Bioquímica quàntica --- Biosíntesi --- Centres actius (Bioquímica) --- Citoquímica --- Composició del cos humà --- Cromatografia --- Digestió --- Enginyeria bioquímica --- Enzimologia --- Equilibri àcid-base --- Fitoquímica --- Fixació de proteïnes --- Genètica bioquímica --- Immunoquímica --- Interfícies biològiques --- Lípids --- Lligands (Bioquímica) --- Marcadors bioquímics --- Metabolisme --- Minerals en l'organisme --- Neuroquímica --- Oxidació fisiològica --- Pigments (Biologia) --- Química biorgànica --- Química clínica --- Química microbiològica --- Quimiotaxi --- Quimiotaxonomia --- Toxicologia bioquímica --- Xenobiòtics --- Histoquímica

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This edited volume comprehensively highlights recent advances in the metabolism, nutrition, physiology, and pathobiology of amino acids in all the systems of humans and other animals (including livestock, poultry, companion animals, and fish). It enables readers to understand the crucial roles of amino acids and their metabolites in the health and diseases of the circulatory, digestive, endocrine, immune, muscular, nervous, reproductive, respiratory, skeletal, and urinary systems, as well as the sense organs (eyes, ears, nose, skin, and tongue). Readers will learn that amino acids are not only the building blocks of protein, but are also signalling molecules, as well as regulators of gene expression, metabolic processes and developmental changes in the body. This knowledge will guide nutritional practices to improve the growth, development and health of humans and other animals, as well as prevent and treat chronic (e.g., obesity, diabetes, and cardiovascular disorders) and infectious (e.g., bacterial, fungal, parasite, and viral) diseases. Editor of this volume is an internationally recognized expert in nutritional biochemistry. He has over 38 years of experience with research and teaching at world-class universities in the area of amino acid biochemistry, nutrition, and physiology. He has published more than 625 papers in peer-reviewed journals, 62 chapters in books, and authored two text/reference books, with an H-index of 117 and more than 55,000 citations in Google Scholar. This publication is a useful reference for professionals as well as undergraduate and graduate students in animal science, biochemistry, biomedical engineering, biology, human medicine, food science, kinesiology, nursing, nutrition, pharmacology, physiology, toxicology, veterinary medicine, and other related disciplines. In addition, all chapters provide general and specific references to amino acids in systems health for researchers and practitioners in biomedicine, animal and plant agriculture, and aquaculture, and for government policy makers.

Immunology. --- Medicine. --- Cell biology. --- Biochemistry. --- Nutrition   . --- Medicine/Public Health, general. --- Cell Biology. --- Biochemistry, general. --- Nutrition. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Health Workforce --- Immunobiology --- Life sciences --- Serology --- Alimentation --- Food --- Nutrition --- Health --- Physiology --- Diet --- Dietetics --- Digestion --- Food habits --- Malnutrition --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Health aspects --- Composition --- Nutrició --- Salut --- Aminoàcids --- Sistema immunitari --- Àcids aminats --- Àcid glutàmic --- Aminoàcids essencials --- Aminoàcids sulfurosos --- Cisteïna --- Glutamina --- Protamines --- Fisiologia --- Medicina --- Condició física --- Descans --- Dieta --- Educació sanitària --- Exercici --- Hàbits sanitaris --- Longevitat --- Salut pública --- Tècnica Alexander --- Medicina holística --- Nutrició humana --- Terapèutica --- Absorció (Fisiologia) --- Àcids grassos en la nutrició --- Desnutrició --- Dietètica --- Fibra alimentària --- Lípids en la nutrició --- Minerals en l'organisme --- Minerals en la nutrició humana --- Nutrició animal --- Nutrició en l'embaràs --- Nutrició vegetal --- Oligoelements en la nutrició --- Preferències alimentàries --- Proteïnes en nutrició humana --- Suplements nutritius --- Vitamines --- Vitamines en la nutrició humana --- Alimentació --- Aliments --- Aliments dietètics --- Dejuni (Dieta) --- Digestió --- Hàbits alimentaris --- Història de la nutrició --- Malalties per carència --- Malnutrició --- Metabolisme --- Nutrigenòmica --- Salut pública dental --- Sistema immunològic --- Anatomia --- Immunologia --- Cèl·lules immunocompetents --- Medul·la òssia --- Sistema limfàtic