Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Endocrine and immune parameters, namely glucocorticoid receptors (GcR) and IFN-gamma production in peripheral blood mononuclear cells (PBMC), and corticosterone in plasma, were studied in groups of four male rabbits observed in seminatural conditions in relation to agonistic behaviour and to seasonal variations. These parameters were selected on the basis of the findings that the presence of GcR in PBMC gives an indication of the in vivo biological effects of glucocorticoids and that PBMC cytokine production and plasma corticosterone are related to social behaviour. The frequency of active and passive behaviours was used to rank the animals. Seasonal variations were present for agonistic behaviours (Attack, Follow, Chase) and For plasma corticosterone, which were significantly higher in winter. IFN-gamma production in PBMC was increased after social interactions in both seasons, while plasma corticosterone was increased only in winter: GcR capacity in PBMC was decreased after social interactions. The results indicate that social and physical environmental factors are correlated with immune-endocrine functions

Agonistic behaviour,seasonal variation,corticosterone,glucocorticoid receptors,ifn-gamma production,rabbit. --- Agonistic behaviour. --- Agonistic. --- Animal. --- Animals. --- Behavior. --- Behaviour. --- Blood mononuclear-cells. --- Blood. --- Corticosterone. --- Dominance. --- Endocrine. --- Frequency. --- Function. --- Glucocorticoid receptors. --- Glucocorticoid. --- Glucocorticoids. --- Group. --- Hippocampal electrical-activity. --- Immune. --- Interaction. --- Interactions. --- Invivo. --- Male. --- Parameters. --- Physical. --- Pituitary. --- Plasma corticosterone. --- Plasma-corticosterone. --- Plasma. --- Production. --- Rabbit. --- Rabbits. --- Rank. --- Receptor. --- Receptors. --- Release. --- Responses. --- Season. --- Seasonal variation. --- Social behaviour. --- Social interaction. --- Social interactions. --- Social-interaction. --- Social. --- Stress. --- Variation.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Postnatal maternal separation increases hypothalamic corticotropin-releasing factor (CRF) gene expression and hypothalamic-pituitary-adrenal (HPA) and behavioral responses to stress. We report here that environmental enrichment during the peripubertal period completely reverses the effects of maternal separation on both HPA and behavioral responses to stress, with no effect on CRF mRNA expression. We conclude that environmental enrichment leads to a functional reversal of the effects of maternal separation through compensation for, rather than reversal of, the neural effects of early life adversity

Behavior. --- Behavioral-responses. --- Compensation. --- Corticotropin-releasing factor. --- Corticotropin-releasing-factor. --- Crf. --- Depression. --- Early experience,environmental enrichment,maternal separation,stress,corticotropin-releasing factor,glucocorticoid receptors. --- Early experience. --- Enrichment. --- Environmental enrichment. --- Expression. --- Gene-expression. --- Gene. --- Generations. --- Hippocampus. --- Hypothalamic-pituitary-adrenal. --- Increase. --- Increases. --- Life. --- Maternal separation. --- Maternal. --- Pituitary-adrenal responses. --- Prenatal stress. --- Rat. --- Reactivity. --- Receptor messenger-rna. --- Response. --- Responses. --- Separation. --- Stress reactivity. --- Stress. --- Transmission.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The present study investigated the effects of post-weaning social isolation (SI) on behavioural and neuroendocrine reactivity to stress of male and female rats. Innate aspects of fear and anxiety were assessed in the open field and elevated plus maze tests. Spontaneous startle reflex and conditioned fear response were further investigated. The neuroendocrine response of isolates was examined by measuring basal and stress release of ACTH and corticosterone and by evaluating the mRNA expression of mineralocorticoid (MR) and glucocorticoid (GR) receptors using in situ hybridization. Locomotor activity in the open field was not modified by chronic SI. In males, but not females, SI produced an anxiogenic profile in the elevated plus maze. Male isolates showed a trend towards increased startle reflex amplitude relative to socially-reared controls. Moreover, SI in males produced alterations of the HPA axis functioning as reflected by higher basal levels of ACTH, and enhanced release of ACTH and corticosterone following stress. In contrast, startle response or HPA axis functioning were not altered in female isolates. Social isolates from both genders showed reduced contextual fear-conditioning. Finally, the mRNA expression of MR and GR was not modified by SI. The results of the present study suggest that chronic SI increases emotional reactivity to stress and produces a hyperfunction of the HPA axis in adult rats, particularly in males. (C) 2003 Elsevier B.V. All rights reserved

Acoustic startle response. --- Acth. --- Activity. --- Adult rats. --- Adult-rat. --- Adult-rats. --- Adult. --- Anxiety. --- Conditioned fear. --- Control. --- Corticosterone. --- Differentially reared rats. --- Elevated plus maze. --- Elevated plus-maze. --- Emotional reactivity. --- Expression. --- Fear. --- Female rats. --- Female. --- Females. --- Field. --- Gender. --- Glucocorticoid receptors. --- Glucocorticoid. --- Hpa axis. --- Hybridization. --- Increase. --- Increases. --- Innate. --- Isolation. --- Latent inhibition. --- Level. --- Locomotor activity. --- Locomotor-activity. --- Male lewis. --- Male. --- Males. --- Maternal separation. --- Mineralocorticoid receptors. --- Neuroendocrine. --- Open field. --- Open-field. --- Post weaning. --- Prepulse inhibition. --- Rat. --- Rats. --- Reactivity. --- Receptor. --- Receptors. --- Reflex. --- Release. --- Response. --- Social isolation. --- Social-isolation. --- Social. --- Sprague-dawley. --- Startle. --- Strain differences. --- Stress. --- Switzerland. --- Test. --- Tests. --- Time.