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The management of patients with a glioma is challenging and best achieved by a team approach encompassing a combination of chemotherapy, radiotherapy, immunotherapy, and surgical excision in a specialist Cancer Center - the balance of treatment depending on the site and grade of tumor. Survival rates are improving and care of patients with or recovering from gliomas is increasingly handled in the community under the care of local physicians. This book provides an authoritative, multi-disciplinary summary of glioma biology, genetics, management and social issues, based on the world-leading program at the Duke University Preston Robert Tisch Brain Tumor Center, one of the world's largest and most successful Centers to offer brain cancer treatment and translational research. The text is written by specialists from this Center, giving it a consistent approach and style. This is an important educational resource for neurologists, neurosurgeons, oncologists, psychiatrists, neurohospitalists and ancillary members of neuro-oncology teams.

Gliomas.

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"Glioblastoma (GBM) or glioma is an extremely aggressive and malignant brain tumor, with cell infiltration, rapid invasion, and a high frequency of relapse. The Glioma Book by neurosurgeon Michael Sughrue is a highly personal book - a culmination of two years of writing and more than 1,000 surgeries. It presents a unique viewpoint with the potential to transform the traditional paradigm that too often informs treatment of this universally fatal brain tumor. The book reinterprets the role of the cerebrum and sub-cortex, leverages scientific advances to improve cytoreduction and reduce neurological deficits, and challenges the myth of the "inoperable" glioma. This is the first step-by-step technical guide focused on aggressively resecting different types of gliomas. The book is logically organized, starting with a foundation of fundamental knowledge, then progressing to practical applications. Chapters focus on the skills necessary to perform glioma surgery, specific techniques, and systematic approaches to gliomas in different brain regions"-- Provided by publisher

Brain --- Surgery. --- Gliomas

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This is truly an exciting time in the field of neuro-oncology, particularly in the area of hi- grade gliomas. The management of patients with high-grade gliomas has historically been one of the most challenging and disheartening fields in medicine, where failure is the rule and longevity is the exception. The jaded often state that despite purported advances in surgical and radiotherapeutic techniques and a myriad of clinical trials of medical therapies, the s- vival statistics for glioblastoma have not changed in the last three decades. The nihilism associated with these tumors is such that some practitioners still advise against treatment or even biopsy, recommending palliative care with the diagnosis based only on history and an MRI scan. If the current state-of-the-art in the diagnosis and management of high-grade gliomas was truly so bleak, there would be no reason to compile and publish a monograph on the subject. The fact is that we have recently entered an era where real progress is being made in our understanding and treatment of high-grade gliomas that is directly benefiting some patients. We are slowly but surely chipping away at this problem. One approach has exploited correlations between particular molecular markers and therapeutic response. The first such “breakthrough” in high-grade glioma was the observation that loss of chromosomes 1p and 19q uniformly predict chemosensitivity in anaplastic oligodendrogliomas (1).

Gliomas. --- Nervous system --- Tumors. --- Tumors

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Gliomas. --- Nervous system --- Tumors --- Glioma. --- Malignant Glioma --- Mixed Glioma --- Glial Cell Tumors --- Glial Cell Tumor --- Glioma, Malignant --- Glioma, Mixed --- Gliomas --- Gliomas, Malignant --- Gliomas, Mixed --- Malignant Gliomas --- Mixed Gliomas --- Tumor, Glial Cell --- Tumors, Glial Cell --- Neurology. --- Medicine --- Neuropsychiatry --- Diseases

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Malignant Gliomas will provide a multidisciplinary update on the treatment of the complex area of malignant gliomas. Authoritative reviews and updates discuss recent advances in radiation therapy including coverage of emerging areas such as BNCT, proton therapy and brachytherapy applications in malignant glioma treatment. In addition, reviews of current developments in advanced and metabolic imaging, neuropathology, surgical approaches, anti-angiogenesis, kinase inhibitors, biomarkers and genetic therapy are included. This volume of Radiation Medicine Rounds will give the radiation oncology pr

Gliomas. --- Brain --- Nervous system --- Tumors. --- Tumors