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The book aims to provide an overview of current knowledge regarding germ cell tumors. It deals with the clinical presentations, treatment modalities, the biology and genetics of germ cell tumors in children and adults. Most chapters are focused on testicular germ cell tumors whose incidence has been increasing in young males. Included are reviews on the pathogenesis, risk factors, diagnosis and treatment regimens applied to precursor, pre-invasive lesions as well as to seminomatous and non-seminomatous germ cell tumors of the testes. In addition, a review is included on the diagnosis and current management options for intracranial germ cell tumors in children. Authors have also contributed articles on the genetics and epigenetics of germ cell tumor development in humans and in the mouse model system. This book will be of interest to scientists, physicians and lay readers wishing to review recent developments in the field of germ cell cancers.
Germ cells. --- Gametocytes --- Germ-line cells --- Germline --- Reproductive cells --- Sex cells --- Cells --- Germplasm resources --- Oncology
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Germ cells --- Neuroptera --- -Ovaries --- Ovary --- Adnexa uteri --- Gonads --- Ovum --- Neuropterans --- Planipennia --- Insects --- Gametocytes --- Germ-line cells --- Germline --- Reproductive cells --- Sex cells --- Cells --- Germplasm resources --- Generative organs --- Ovaries
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This book focuses on the development and biology of germ cell and is edited by Ahmed RG, associate professor and Doctor of Developmental and Experimental Biology, Division of Anatomy and Embryology, Zoology Department, Faculty of Science, Beni-Suef University, Egypt. While many articles have appeared in journals on germ cell, this book provides you with a rare treat - an extensive and intensive study on it. It is one of a kind, offering important and valuable information about the biology of germ cell. This book covers the specification, regulation, and reprogramming of germ cell and germ line stem cells. This book provides important information about the new insight into germ cell signaling and the genotoxic in vitro studies in testicular germ cells. This book offers significant results about the origin, specification, and development of the female germ line in placental mammals and the germ cell tumors and their association with pregnancy.
Germ cells. --- Gametocytes --- Germ-line cells --- Germline --- Reproductive cells --- Sex cells --- Cells --- Germplasm resources --- Life Sciences --- Immunology and Microbiology --- Reproductive Immunology --- Pure Immunology
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Germ cell tumors are relatively rare compared with other malignancies, and compilations of knowledge that encompass the entire spectrum of the disease are lacking. This textbook, written by the foremost authorities in the field, rectifies the situation by discussing in depth a broad range of topics, including biology, epidemiology, pathology, treatment, and late effects. Bearing in mind that germ cell tumors are most prevalent in the adolescent and young adult age group, causes of disease and treatment approaches in pediatric and adult patients are compared and contrasted. By spanning the entire life course, from prenatal origins of disease through to treatment in adults and late effects of treatment, the editors have produced a book that will be of interest to both pediatric and adult oncologists.
Tumors in children --- Germ cells --- Treatment. --- Tumors --- Gametocytes --- Germ-line cells --- Germline --- Reproductive cells --- Sex cells --- Pediatric oncology --- Medicine. --- Oncology. --- Pediatrics. --- Medicine & Public Health. --- Paediatrics --- Pediatric medicine --- Medicine --- Children --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Diseases --- Health and hygiene --- Cells --- Germplasm resources --- Oncology .
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This book provides, for the first time, a detailed, up-to-date, holistic approach to the pathology and biology of germ cell tumors. The main focus is the complex histopathology of these tumors, but special considerations are also given to their morphologic variations in relation to age, gender and organ. Critical updates are provided on terminology and classification; the discussion of biology and pathogenesis includes references to many molecular genetic and immunohistochemical findings from recent stem cell research. Individual chapters are devoted to germ cell tumors at different anatomic locations, including not only the ovaries and testes but also the mediastinum and central nervous system, and pediatric tumors. All of the contributing authors are opinion leaders from universities of excellence in Europe and the United States. This monograph will be of wide interest to practitioners and researchers in many fields of medicine, including pathology, gynecology, urology, and pediatrics, as well as stem cell scientists.
Medicine. --- Gynecology. --- Internal medicine. --- Pathology. --- Pediatrics. --- Urology. --- Medicine & Public Health. --- Internal Medicine. --- Germ cells. --- Gametocytes --- Germ-line cells --- Germline --- Reproductive cells --- Sex cells --- Medicine --- Genitourinary organs --- Paediatrics --- Pediatric medicine --- Children --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Medicine, Internal --- Gynaecology --- Generative organs, Female --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Health and hygiene --- Cells --- Germplasm resources --- Gynecology .
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Chromosome Aberrations --- DNA Damage --- Germ Cells --- Mutagenicity Tests --- Mutation --- Mutations --- Polymorphism, Restriction Fragment Length --- Germ Line --- Gamete --- Gametes --- Germ-Line Cells --- Cell, Germ --- Cell, Germ-Line --- Cells, Germ --- Cells, Germ-Line --- Germ Cell --- Germ Line Cells --- Germ Lines --- Germ-Line Cell --- Injury, DNA --- DNA Injury --- Genotoxic Stress --- Stress, Genotoxic --- DNA Damages --- DNA Injuries --- Damage, DNA --- Damages, DNA --- Genotoxic Stresses --- Injuries, DNA --- Stresses, Genotoxic --- Pyrimidine Dimers --- Comet Assay --- DNA Repair Enzymes --- Abnormalities, Autosome --- Abnormalities, Chromosomal --- Abnormalities, Chromosome --- Chromosomal Aberrations --- Chromosome Abnormalities --- Cytogenetic Abnormalities --- Autosome Abnormalities --- Cytogenetic Aberrations --- Aberration, Chromosomal --- Aberration, Chromosome --- Aberration, Cytogenetic --- Aberrations, Chromosomal --- Aberrations, Chromosome --- Aberrations, Cytogenetic --- Abnormalities, Cytogenetic --- Abnormality, Autosome --- Abnormality, Chromosomal --- Abnormality, Chromosome --- Abnormality, Cytogenetic --- Autosome Abnormality --- Chromosomal Aberration --- Chromosomal Abnormalities --- Chromosomal Abnormality --- Chromosome Aberration --- Chromosome Abnormality --- Cytogenetic Aberration --- Cytogenetic Abnormality --- Chromosomes --- Cytogenetics --- Genetics, Medical --- Cytogenetic Analysis --- methods --- abnormalities
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Unwanted childlessness affects approximately one in six couples worldwide. - though the exact proportion of the predominant cause of the problem remains controversial, according to the World Health Organization (WHO), in nearly 40% of cases the cause can be attributed to the female, in 20% to the male, in 25% to both, and in 15% the cause remains unknown. Based on these ?gures, the - cidence of male factor infertility in the general population is approximately 7%. The majority of these men, approximately 30%, experience irreversible idiopathic infertility and cannot father children without some form of medical intervention. Male factor infertility, in addition, may be caused by testicular germ cell cancer, which is known to represent the most common cancer among young men, aged 15 to 35 years, in Western industrialized countries. The number of affected men has increased dramatically over the past 50 years. There is now growing evidence that human testicular germ cell cancer originates from fetal germ cells exhibiting an aberrant programme of gene expression, and tumour progression may be favoured by an aberrant Sertoli cell-germ cell communication.
Sertoli cells. --- Germ cells. --- Spermatogenesis. --- Infertility, Male. --- Male infertility --- Male sterility --- Sterility, Male --- Generative organs, Male --- Infertility --- Formation of spermatozoa --- Spermatozoa --- Gametogenesis --- Gametocytes --- Germ-line cells --- Germline --- Reproductive cells --- Sex cells --- Cells --- Germplasm resources --- Cells of Sertoli --- Sertoli's cells --- Sustentacular cells --- Testis --- Diseases --- Formation --- Medicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general. --- Medicine --- Biology --- Biomedical Research. --- Research. --- Biological research --- Biomedical research
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General embryology. Developmental biology --- Cell differentiation --- Cellular control mechanisms --- Developmental cytology --- Germ cells --- Somatic cells --- Cells --- Gametocytes --- Germ-line cells --- Germline --- Reproductive cells --- Sex cells --- Germplasm resources --- Cytology --- Cell regulation --- Biological control systems --- Cell metabolism --- Cell fate specification --- Cell specification --- Differentiation of cells --- Fate specification of cells --- Specification of cells --- Morphogenesis --- Differentiation --- Fate specification --- Specification --- Cell differentiation. --- Cellular control mechanisms. --- Developmental cytology. --- Germ cells. --- Somatic cells. --- Cytologie --- Cellules --- Regulation cellulaire --- Cellules germinales
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Fertilization (Biology) --- Germ cells. --- Mammals --- Reproduction. --- Physiology. --- Fertilization (Biology). --- -Reproduction --- 599 --- 591.3 --- Amphimixis --- Generation --- Pangenesis --- Procreation --- Theriogenology --- Hormones, Sex. --- Embryology. --- Hormones, Sex --- -#ABIB:aeco --- embryology. --- Female sex hormone --- Male sex hormone --- Sex hormones --- Steroid hormones --- 591.16 --- 591.16 Generation. Procreation. Reproduction. Breeding. Biogenesis --- Generation. Procreation. Reproduction. Breeding. Biogenesis --- #ABIB:aeco --- Fetus --- <3/87 --- Fetal development --- Intrauterine development --- Developmental biology --- Development --- Embryology --- embryology --- Reproduction --- #ABIB:aleo --- Biology --- Life (Biology) --- Physiology --- Sex (Biology) --- Generative organs --- Hormones --- Germ cells --- Gametocytes --- Germ-line cells --- Germline --- Reproductive cells --- Sex cells --- Cells --- Germplasm resources --- Animal embryology and growth --- Development. --- Mammals - Physiology --- Mammals - Embryology
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Germ cells in sexually reproducing metazoa, through the germline lineage, are the route by which genetic material and cytoplasmic constituents are passed from one generation to the next in the continuum of life. Chapters in this book review germ cell development in the model organism Caenorhabditis elegans, discussing the biology, the genetics and the molecular mechanisms for various processes, as well as drawing comparisons with other organisms. Processes discussed include specification of germ cell fate, meiosis, gametogenesis, environmental/ physiological controls, epigenetics and translational control, fertilization and the oocyte-to-embryo transition. This book thus provides a comprehensive picture of the germline lineage and the continuum of life for the worm.
Genetic Phenomena. --- Genetics. --- Caenorhabditis elegans --- Germ cells --- Cells --- Caenorhabditis --- Genitalia --- Physiological Processes --- Physiological Phenomena --- Rhabditoidea --- Urogenital System --- Anatomy --- Phenomena and Processes --- Rhabditida --- Secernentea --- Nematoda --- Helminths --- Invertebrates --- Animals --- Eukaryota --- Organisms --- Growth and Development --- Germ Cells --- Biology --- Zoology --- Medicine --- Health & Biological Sciences --- Pathology --- Genetics --- Animal Anatomy & Embryology --- Differentiation --- Germ cells. --- Developmental cytology. --- Caenorhabditis elegans. --- Gametocytes --- Germ-line cells --- Germline --- Reproductive cells --- Sex cells --- Medicine. --- Human genetics. --- Cell biology. --- Developmental biology. --- Biomedicine. --- Human Genetics. --- Cell Biology. --- Developmental Biology. --- Development (Biology) --- Growth --- Ontogeny --- Cell biology --- Cellular biology --- Cytologists --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Physicians --- Germplasm resources --- Cytology --- Cytology. --- Differentiation. --- growth & development. --- cytology. --- Germ cell differentiation --- Cell differentiation
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