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This detailed volume provides a comprehensive collection of protocols for epigenomic research, powering our ability to analyze epigenetic modifications across the entire genome. Beginning with methods used to investigate epigenomic modifications such as DNA methylation, histone modifications, and chromatin structure, the book continues with methods for manipulating the epigenome, including platforms for epigenome editing, inducible systems for epigenome editing, and epigenetically modified animals. Written for the highly successful Methods in Molecular Biology series, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Epigenomics: Methods and Protocols serves as an ideal resource for researchers looking to further expand the utility and scope of epigenomics research.

Epigenetics. --- Biology—Technique. --- Genomics. --- Genomic Analysis. --- Genome research --- Genomes --- Molecular genetics --- Genetics --- Research

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Epigenetics in Biological Communication is the first book that integrates Development, Signaling, Context, Genetics and Evolution. Every cell, tissue, organ and organism is competent to use signals to exchange information reaching common coordinations and organisations of both single cell and group behavior. These signal-mediated interactions we term biological communication (biocommunication). The regulatory system that works in development, morphology, cell fate and identity, physiology, genetic instructions, immunity, memory/learning, physical and mental disease depends on epigenetic marks. The communication of cells, persistent viruses and their defectives such as mobile genetic elements and RNA networks ensures both the transport of regulatory instructions and the reprogramming of these instructions. But how are the different states of the epigenome orchestrated? With the emergence of epigenetic memory, organisms can fix historical and context- dependent impressive experiences. Evolution from now on learnt to learn. Learning means organisms can avoid reproduction of always the same. This is key to adaptation. However, inheritance of acquired characteristics is only one of the many examples of the explanatory power of epigenetics. Behavioral epigenetics demonstrates the way in which environmental and social experiences produce individual differences in behavior, cognition, personality, and mental health. This book assembles leading experts to outline the various motifs of epigenetic regulation of cellular life.

Genetics --- Biotechnology --- genetica --- biotechnologie --- Biology --- Genomics. --- Genetics. --- Evolutionary genetics. --- Epigenetics. --- Genomic Analysis. --- Evolutionary Genetics. --- Technique.

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This textbook teaches health analytics using examples from the statistical programming language R. It utilizes real-world examples with publicly available datasets from healthcare and direct-to-consumer genetics to provide learners with real-world examples and enable them to get their hands on actual data. This textbook is designed to accompany either a senior-level undergraduate course or a Masters level graduate course on health analytics. The reader will advance from no prior knowledge of R to being well versed in applications within R that apply to data science and health analytics. “I have never seen a book like this and think it will make an important contribution to the field. I really like that it covers environmental, social, and geospatial data. I also really like the coverage of ethics. These aspects of health analytics are often overlooked or deemphasized. I will definitely buy copies for my team.” - Jason Moore, Cedars-Sinai Medical Center “Overall, I have a highly positive impression of the book. It is VERY comprehensive. It covers very extensive data types. I do not recall other books with the same level of comprehensiveness.” - Shuangge Ma, Yale University “The book is comprehensive in both aspects of genetics, and health analytics. It covers any type of information a healthcare data scientist should be familiar with, whether they are novice or experienced. I found any chapter that I looked into comprehensive, but also not too detailed (although in general this book is more than 600 pages of comprehensive and detailed relevant information).” - Robert Moskovtich, Ben-Gurion University of the Negev.

Biology --- Gene expression. --- Quantitative research. --- Genetics. --- Genomics. --- Artificial intelligence --- Gene Expression Analysis. --- Data Analysis and Big Data. --- Biological Techniques. --- Genomic Analysis. --- Data Science. --- Technique. --- Data processing.

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Genomics --- Genetic Research --- Pharmacogenetics --- Human genome --- Génomique --- Génome humain --- Periodicals. --- Périodiques --- Genomics. --- Human genome. --- Pharmacogenomics --- Research, Genetic --- Genome research --- Genomes --- Research --- genomic analysis --- comparative genomics --- Genetic Research. --- Pharmacogenetics. --- Human chromosomes --- Molecular genetics --- Pharmacogenomic Variants --- Drug Resistance --- Toxicology --- Precision Medicine --- Genetics --- Human medicine --- Génomique --- Génome humain --- Genètica. --- Genoma humà. --- Genètica. --- Genoma humà.

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This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems. The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability of the genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.

Cell differentiation. --- Cell nuclei. --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cell nucleus --- Nucleus (Cells) --- Cell organelles --- Cell fate specification --- Cell specification --- Differentiation of cells --- Fate specification of cells --- Specification of cells --- Morphogenesis --- Differentiation --- Fate specification --- Specification --- Chromosomes. --- Genomics. --- Biomaterials. --- Nucleic acids. --- Gene expression. --- Nuclear Organization. --- Genomic Analysis. --- Nucleic Acid. --- Gene Expression Analysis. --- Technique. --- Genes --- Genetic regulation --- Polynucleotides --- Biomolecules --- Genome research --- Genomes --- Molecular genetics --- Chromosome theory --- Cell nuclei --- Crossing over (Genetics) --- Cytotaxonomy --- Genetics --- Karyokinesis --- Linkage (Genetics) --- Expression --- Research --- Citologia --- Cromosomes --- Genòmica --- Nuclis cel·lulars --- Diferenciació cel·lular