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DNA Methylation --- Genes, Neoplasm --- CDCA7L protein, human

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Cancer --- Systems biology. --- Neoplasms --- Gene Expression Regulation, Neoplastic --- Gene Regulatory Networks --- Genes, Neoplasm --- Systems Biology --- Gene regulatory networks. --- Research --- Methodology. --- genetics. --- physiology. --- methods.

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Carcinoembryonic Antigen. --- alpha-Fetoproteins. --- Neoplasm Proteins. --- Neoplasms --- Proteins, Neoplasm --- Genes, Neoplasm --- Antigen, CD66e --- Antigens, CD66e --- CD66e Antigen --- Antigen, Carcinoembryonic --- CD66e Antigens --- immunology. --- alpha-Fetoprotein --- alpha Fetoprotein --- alpha Fetoproteins --- Anencephaly --- Carcinoembryonic Antigen --- alpha-Fetoproteins --- Neoplasm Proteins --- immunology

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Bioinformatic integration of the findings from recent genomic and proteomic research has made possible the development of highly selective therapeutics that can target specific cellular pathways controlling cell proliferation, differentiation, metastasis, evasion of immune surveillance, angiogenesis, and apoptosis. In The Oncogenomics Handbook, a panel of internationally recognized researchers and clinicians provides an integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following that path, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including rituximab, Herceptin®, Avastin™, ABGX-EGF, Velcade®, Iressa®, and Zevalin® are addressed. Additional chapters review clinical diagnostics, bioanalytics, and biomarkers and their importance to therapeutic outcome; detail antiangiogenic, supportive, immunomodulatory, and tumor-targeted approaches to cancer therapy; and provide a systems biology-bioinformatics overview of strategies and initiatives for the postgenomic era. Highlights include cancer genomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation. Authoritative and state-of-the-art, The Oncogenomics Handbook offers cancer researchers and drug developers a comprehensive update on the contribution of the genomic revolution to cancer drug discovery and development.

Cancer --- Oncogenes --- Genomics --- Proteomics --- Oncogènes --- Génomique --- Protéomique --- Genetic aspects --- Handbooks, manuals, etc. --- Aspect génétique --- Guides, manuels, etc. --- Cancer -- Genetic aspects -- Handbooks, manuals, etc. --- Genomics -- Handbooks, manuals, etc. --- Oncogenes -- Handbooks, manuals, etc. --- Proteomics -- Handbooks, manuals, etc. --- Genes, Neoplasm --- Diseases --- Biology --- Computational Biology --- Genes --- Biological Science Disciplines --- Genome Components --- Natural Science Disciplines --- Disciplines and Occupations --- Genome --- Genetic Structures --- Genetic Phenomena --- Phenomena and Processes --- Genetics --- Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Genome research --- Genomes --- Onc genes --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Research --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Molecular biology --- Proteins --- Molecular genetics --- Cancer genes --- Proto-oncogenes --- Oncology  .

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Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors.   Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors.   Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and  medical oncologists.

Cancer -- Genetic aspects. --- Cancer genes. --- Gene expression. --- Gene expression --- Cancer genes --- Cancer --- Genetic Techniques --- Biology --- Genes --- Biological Science Disciplines --- Genome Components --- Investigative Techniques --- Natural Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genome --- Genetic Structures --- Disciplines and Occupations --- Genetic Phenomena --- Phenomena and Processes --- Genetics --- Genes, Neoplasm --- Gene Expression Profiling --- Medicine --- Health & Biological Sciences --- Pathology --- Oncology --- Genetic aspects --- Gene therapy. --- Therapy, Gene --- Expression --- Medicine. --- Laboratory medicine. --- Oncology. --- Pathology. --- Medicine & Public Health. --- Laboratory Medicine. --- Genetic engineering --- Therapeutics --- Genetic regulation --- Oncology  . --- Medical laboratories. --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Tumors --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis