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Begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease.--
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Begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease.--
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Gene expression --- Gene expression. --- Cytology --- Gene expression regulation --- Genes --- Congresses.
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This dissertation by Mohammad Atikuzzaman explores the biochemical interactions between seminal fluid components and the female reproductive tract in poultry and pigs. It examines the gene expression changes in the pre-ovulatory sperm reservoir, highlighting the influence of sperm-free seminal fluid and mating on gene expression. The research focuses on the proteome and cytokine content of seminal fluid, alongside gene expression analyses in the oviductal sperm reservoirs of sexually mature females. The study offers insights into the immune tolerance mechanisms that allow sperm preservation in the female tract, contributing to fertility. It emphasizes the evolutionary conservation of these mechanisms across species with different reproductive strategies.
Gene expression. --- Proteomics. --- Gene expression --- Proteomics
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This dissertation by Linda Engström investigates gene expression in the brain and adrenal gland during systemic immune challenges. It examines the role of endotoxins and cytokines in activating the autonomic nervous system and their effects on homeostasis. The research focuses on the expression of enkephalin and prostaglandin E2 within rat models, exploring their influence on stress hormone release and immune responses. The study reveals mechanisms of neuronal and humoral pathways in the hypothalamic-pituitary-adrenal (HPA) axis, highlighting the complex interactions between the nervous and immune systems. Aimed at researchers and students in medical and health sciences, it provides insights into neuroimmune communication.
Neuroimmunology. --- Gene expression. --- Neuroimmunology --- Gene expression
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This volume provides new approaches and technologies into roles of poly(A) metabolism in translation, RNA stability, and quality control of gene expression. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Deadenylation: Methods and Protocols aims to pave the way for future investigations of the complex regulatory networks that control mRNA stability and expression.
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