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"An ethically informed analysis of gene drives used to combat malaria in African countries, written by a leading bioethics scholar."

Malaria --- Gene drives --- Mosquitoes

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In the ‘Fifth Gene Technology Report’, renowned experts provide an overview of current developments and their applications in the dynamically evolving research field of gene and biotechnologies. They examine, among other topics, genetic diagnostics, somatic gene therapy, the development of vaccines, stem cell and organoid research, green gene technology, synthetic biology, gene drives, genome editing, epigenetics and single cell analysis. In addition to reporting on the current state of affairs in this field, the authors also discuss society’s perception of gene technologies and ethical and legal issues relating to them, such as genome edit-ing, cerebral organoids and big data in personalised medicine. Moreover, the interdisciplinary task force ‘Gentechnologiebericht’ (Gene Technology Report) offers recommendations on action that could be taken in relation to the key issues. With contributions by Karla Alex, Sina Bartfeld, Meik Bittkowski, Inge Broer, Lorina Buhr, Stephan Clemens, Wolfgang Van den Daele, Hans-Georg Dederer, Tobias J. Erb, Nina Gasparoni, Heiner Fangerau, Boris Fehse, Jürgen Hampel, Louise Herde, Ferdinand Hucho, Ali Jawaid, Aida Khachatryan, Sarah Kohler, Alma Kolleck, Martin Korte, Cordula Kropp, Alfons Labisch, Markus Lehmkuhl, Melanie Leidecker-Sandmann, Annette Leßmöllmann, Isabelle M. Mansuy, Lilian Marx-Stölting, Andreas Merk, Yannick Milhahn, Fruzsina Molnár-Gábor, Stefan Mundlos, Staffan Müller-Wille, Angela Osterheider, Anja Pichl, Barbara Prainsack, Jens Reich, Marlen Reinschke, Ortwin Renn, Hans-Jörg Rheinberger, Arnold Sauter, Hannah Schickl, Silke Schicktanz, Volker Stollorz, Constanze Störk-Biber, Jochen Taupitz, Jörn Walter, Eva C. Winkler, Martin Zenke and Michael M. Zwick. Im „Fünften Gentechnologiebericht“ bieten namhafte Expertinnen und Experten einen Überblick über aktuelle Entwicklungen des dynamischen Forschungsfeldes der Gen- und Biotechnologien und ihrer Anwendungen. In den Bick genommen werden u. a. genetische Diagnostik, somatische Gentherapie, Impfstoffentwicklung, Stammzell- und Organoidforschung, Grüne Gentechnik, Synthetische Biologie, Gene Drives, Genome-Editing, Epigenetik und Einzelzellanalyse. Neben Sachstandsberichten werden auch die gesellschaftliche Wahrnehmung der Gentechnologien sowie ethische und rechtliche Fragen erörtert, u. a. zu Genome-Editing, Hirnorganoiden und Big Data in der personalisierten Medizin. Die interdisziplinäre Arbeitsgruppe Gentechnologiebericht gibt außerdem Handlungsempfehlungen zu zentralen Themen. Mit Beiträgen von Karla Alex, Sina Bartfeld, Meik Bittkowski, Inge Broer, Lorina Buhr, Stephan Clemens, Wolfgang Van den Daele, Hans-Georg Dederer, Tobias J. Erb, Nina Gasparoni, Heiner Fangerau, Boris Fehse, Jürgen Hampel, Louise Herde, Ferdinand Hucho, Ali Jawaid, Aida Khachatryan, Sarah Kohler, Alma Kolleck, Martin Korte, Cordula Kropp, Alfons Labisch, Markus Lehmkuhl, Melanie Leidecker-Sandmann, Annette Leßmöllmann, Isabelle M. Mansuy, Lilian Marx-Stölting, Andreas Merk, Yannick Milhahn, Fruzsina Molnár-Gábor, Stefan Mundlos, Staffan Müller-Wille, Angela Osterheider, Anja Pichl, Barbara Prainsack, Jens Reich, Marlen Reinschke, Ortwin Renn, Hans-Jörg Rheinberger, Arnold Sauter, Hannah Schickl, Silke Schicktanz, Volker Stollorz, Constanze Störk-Biber, Jochen Taupitz, Jörn Walter, Eva C. Winkler, Martin Zenke und Michael M. Zwick.

MBP, KCQ, JFMG --- Biologie Ethik Forschung Gene Gesundheit Medizin Gentechnologie Grüne Gentechnik Synthetische Biologie Epigenetik Einzelzellanalyse Gene Drives Organoide Stammzellforschung Hirnorganoide Embryoide Datenschutz Monitoring Genbegriff Genom Gendeterminismus

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"Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators"--

Genetic engineering --- Transgenic organisms --- Moral and ethical aspects --- Health aspects --- Risk assessment --- Gene drives --- Designed genetic change --- Engineering, Genetic --- Gene splicing --- Genetic intervention --- Genetic surgery --- Genetic recombination --- Biotechnology --- Genetically engineered organisms --- Genetically modified organisms --- GEOs (Genetically engineered organisms) --- GMOs (Genetically modified organisms) --- Organisms

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Who is liable if self-spreading biotechnology causes transboundary harm? With engineered gene drives and similar techniques, the genes of wild-living species, pathogens, and crop plants can soon be modified directly in the environment. This might help address pressing public health, environmental, and food security problems. However, these techniques may also spread across national borders. Looking at both states and private actors, this book studies the rules of international law on the prevention of, and liability for, adverse transboundary effects caused by self-spreading biotechnology. Through an in-depth analysis of the relevant treaties and custom, it shows that international law is not yet equipped to cope with the challenges ahead.

Biodiversity Compact, Biotechnologie, Cartagena-Protokoll, gene drives, Genomeditierung, Gewohnheitsrecht, living modified organisms, Malaria, Nagoya/Kuala-Lumpur-Haftungsprotokoll, Rechtsquellen des Völkerrechts, selbstausbreitende Biotechnologie, soft law, Staatenverantwortlichkeit, völkerrechtliche Verantwortlichkeit und Haftung beim grenzüberschreitenden Einsatz von Biotechnologie Völkerrechtliche Verträge, Cartagena Protocol, Convention on Biological Diversity, Genome Editing, HEGAAs, International Law, Liability, Prevention, State Responsibility, Transboundary Harm