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This atlas will illustrate the distribution and morphological features of interstitial cells of Cajal (ICC) which are the key cells to understanding of the regulatory mechanism of gastrointestinal motility, since ICC act as both pacemaker and as intermediates in neural transmission, and since ICC show specific distribution patterns depending on their anatomical positions. All subtypes of ICC located in the different tissue layers and different levels of the gastrointestinal tract will be revealed by immunohistochemistry for Kit receptors and nerves by using mainly whole-mount stretch preparation of the guinea-pig tissues. Three-dimensional reconstruction of confocal images will particularly help the readers to understand the peculiar arrangement of ICC networks in situ and the correlation between ICC and nerves. Electron micrographs will help illustrate the characteristic features of ICC and their ultrastructural differences from fibroblasts, smooth muscles and other interstitial cells.

Biomedicine. --- Gastrointestinal system -- Cytology -- Atlases. --- Medicine. --- Histocytochemistry --- Muscle Cells --- Microscopy --- Immunologic Tests --- Immunochemistry --- Biochemistry --- Laboratory Techniques and Procedures --- Diagnostic Imaging --- Cytological Techniques --- Investigative Techniques --- Histological Techniques --- Immunologic Techniques --- Cells --- Histology --- Clinical Laboratory Techniques --- Diagnosis --- Anatomy --- Diagnostic Techniques and Procedures --- Biological Science Disciplines --- Chemistry --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Natural Science Disciplines --- Disciplines and Occupations --- Immunohistochemistry --- Interstitial Cells of Cajal --- Microscopy, Confocal --- Biology --- Medicine --- Health & Biological Sciences --- Cytology --- Urology & Nephrology --- Interstitial cystitis. --- Gastrointestinal system --- Diseases. --- Bladder pain syndrome --- BPS (Bladder pain syndrome) --- Hunner's ulcer --- IC (Interstitial cystitis) --- IC/PBS (Interstitial cystitis) --- Painful bladder syndrome --- PBS (Painful bladder syndrome) --- Biomedicine general. --- Cystitis --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general.