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Surgery --- Chirurgie --- Periodicals --- Périodiques --- MDSURGER --- surgery --- general surgery --- gastric cancer --- digestive surgery --- Surgery. --- General Surgery. --- Surgery, General --- Surgical Procedures, Operative --- Surgery, Primitive --- Medicine --- General Surgery

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Gastric cancer represents one of the most frequent and lethal tumors worldwide today, finding itself in the fifth place in incidence and the third in mortality. Surgery remains the only curative treatment for localized tumors, but only 20% of patients are suitable for surgery due to the lack of specific symptoms and the late diagnosis, especially in Western countries. Additionally, even in patients who receive curative treatment, rates of locoregional relapse and distant metastasis remain high. Palliative chemotherapy is the principal treatment in cases of metastatic disease even if the prognosis of patients receiving chemotherapy is still poor. Therefore, a multidisciplinary evaluation is important in order to improve the efficacy of active treatments. In this context, there is an unmet need for a better understanding of genetic alterations and prognostic and predictive factors in order to choose the best tailored therapy for each patient. The aim of this Special Issue is to focus on the results and problems of multimodality treatment in metastatic gastric cancer, the search for prognostic and predictive factors, and the evaluation of novel strategies for individualized treatment. We are inviting relevant original research, systematic reviews, meta-analyses, and short communications covering the above-mentioned topics.

advanced gastric cancer --- precision medicine --- new drug development --- gastro-oesophageal cancer --- mutational concordance --- exome sequencing --- formalin fixed paraffin embedded --- biomarkers --- gastric cancer --- metastatic --- body composition --- sarcopenia --- visceral fat area --- subcutaneous fat area --- outcome --- toxicity --- liver metastasis --- conversion surgery --- hepatectomy --- stage iv gastric cancer --- immune checkpoint inhibitors --- Epstein Barr Virus --- tumor mutational burden --- microsatellite instability --- predictive biomarkers --- CAR T cell therapy --- vaccines --- nutritional status --- metastatic gastric cancer --- target therapy --- bone flare --- stage IV --- treatment --- RANK-L --- liquid biopsy --- circulating tumor cell --- cfDNA --- ctDNA --- epithelial–mesenchymal transition --- resistance to treatment --- HER2-inhibition --- VEGFR-inhibition --- immunotherapy --- response monitoring --- n/a --- epithelial-mesenchymal transition

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Pharmacology --- Gastrointestinal disorders --- Hepatic --- Gut --- Irritable Bowel Syndrome --- Brain-gut interactions --- Intestinal inflammation --- Liver inflammation --- Gastric cancer --- Colorectal Cancer --- Pancreatitis

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Stomach --- Stomach Neoplasms --- Cancer --- Stomach Neoplasms. --- Tumors --- Diseases --- Cancer. --- Diseases. --- Tumors. --- Cancer of the Stomach --- Gastric Cancer, Familial Diffuse --- Neoplasms, Gastric --- Neoplasms, Stomach --- Cancer of Stomach --- Gastric Cancer --- Gastric Neoplasms --- Stomach Cancer --- Cancer, Gastric --- Cancer, Stomach --- Cancers, Gastric --- Cancers, Stomach --- Gastric Cancers --- Gastric Neoplasm --- Neoplasm, Gastric --- Neoplasm, Stomach --- Stomach Cancers --- Stomach Neoplasm --- Gastric diseases --- Magenkrebs --- Zeitschrift --- Online-Ressource --- Netzpublikation --- Online-Publikation --- Computerdatei im Fernzugriff --- Online-Dokument --- On-line-Dokument --- On-line-Publikation --- Periodikum --- Zeitschriften --- Carcinoma ventriculi --- Magencarcinom --- Magenkarzinom --- Abdomen --- Gastrointestinal system --- Presse --- Fortlaufendes Sammelwerk --- Krebs --- Magentumor --- Elektronische Publikation --- stomach neoplasms. --- gastric cancer --- gastric neoplasms --- gastric tumors --- gastric tumours --- stomach cancer --- stomach tumors --- stomach tumours --- gastrointestinal neoplasms --- stomach --- Magenkrebs. --- Zeitschrift. --- Online-Ressource.

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This book highlights the importance of understanding gastric and colon cancer metabolism in guiding diagnosis and drug discovery. It summarizes the correlation between adiponectin and matrix metalloproteinase with colorectal cancer. The book also evaluates the divergent role of hypoxia-inducible factor 1 in colorectal cancer growth and metastasis. After discussing the role of genetic polymorphisms in alcohol metabolizing enzymes and EPHX1 with the onset of colorectal cancer, it reviews the molecular mechanisms of chemoresistance in gastric cancer and novel therapeutic strategies to reverse the chemoresistance of tumors. In addition, the book explores the theranostic role of nanoparticles and therapeutic potential of phytochemicals with regard to colorectal cancer. Given its scope, the book offers a valuable guide for oncologists, academic researchers, pharmaceuticals practitioners, and students who are involved in research and treatment of cancer.

Cancer research. --- Gastroenterology . --- Oncology  . --- Genetics. --- Cancer Research. --- Gastroenterology. --- Oncology. --- Genetics and Genomics. --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Tumors --- Internal medicine --- Digestive organs --- Cancer research --- Diseases --- Stomach --- Cancer. --- Colonic Neoplasms. --- Stomach Neoplasms. --- Cancer of the Stomach --- Gastric Cancer, Familial Diffuse --- Neoplasms, Gastric --- Neoplasms, Stomach --- Cancer of Stomach --- Gastric Cancer --- Gastric Neoplasms --- Stomach Cancer --- Cancer, Gastric --- Cancer, Stomach --- Cancers, Gastric --- Cancers, Stomach --- Gastric Cancers --- Gastric Neoplasm --- Neoplasm, Gastric --- Neoplasm, Stomach --- Stomach Cancers --- Stomach Neoplasm --- Cancer of the Colon --- Colon Neoplasms --- Colonic Cancer --- Neoplasms, Colonic --- Cancer of Colon --- Colon Cancer --- Cancer, Colon --- Cancer, Colonic --- Cancers, Colon --- Cancers, Colonic --- Colon Cancers --- Colon Neoplasm --- Colonic Cancers --- Colonic Neoplasm --- Neoplasm, Colon --- Neoplasm, Colonic --- Neoplasms, Colon --- Cancer --- Research.