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This is the first book to bring together the history, theory, mathematical approach, measurement details and limitations of the Multiple Inert Gas Elimination Technique (MIGET) and a summary of the global literature on its application in health and disease over the last 40 years. Up to the early 1970's, and despite substantial research carried out by leaders in respiratory physiology, it was not possible to measure the most important and most complex component of gas exchange in the lung: ventilation/perfusion (VA/Q) heterogeneity. Building on that earlier research, MIGET was developed to overcome this large gap in our understanding of the most important function of the lung. Just as CT and MRI make use of multiple, simultaneous imaging views to reconstruct the underlying anatomy spatially, MIGET uses the simultaneous exchange of six inert gases with differing blood solubility to reconstruct the functional distribution of VA/Q ratios. While the basic physiological principle of MIGET is straightforward, using inert gas exchange data to construct the VA/Q distribution requires complicated mathematics along with the ability to simultaneously measure the exchange of six foreign gases present in just parts per million or less. This unique book is a valuable resource for anyone interested in how the lung works.

Medicine. --- Human physiology. --- Respiratory organs --- Sports medicine. --- Biomedicine. --- Human Physiology. --- Pneumology/Respiratory System. --- Sports Medicine. --- Diseases. --- Pulmonary gas exchange. --- Gas exchange, Pulmonary --- Pulmonary respiration --- Respiration --- Pneumology. --- Human biology --- Medical sciences --- Physiology --- Human body --- Athletic medicine --- Athletics --- Medicine and sports --- Physical education and training --- Sports --- Medicine --- Sports sciences --- Medical aspects --- Respiratory organs—Diseases.

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This book encapsulates over three decades of the author’s work on comparative functional respiratory morphology. It provides insights into the mechanism(s) by which respiratory means and processes originated and advanced to their modern states. Pertinent cross-disciplinary details and facts have been integrated and reexamined in order to arrive at more robust answers to questions regarding the basis of the functional designs of gas exchangers. The utilization of oxygen for energy production is an ancient process, the development and progression of which were underpinned by dynamic events in the biological, physical, and chemical worlds. Many books that have broached the subject of comparative functional respiratory biology have only described the form and function of the ‘end-product,’ the gas exchanger; they have scarcely delved into the factors and the conditions that motivated and steered the development from primeval to modern respiratory means and processes. This book addresses and answers broad questions concerning the critical synthesis of multidisciplinary data, and clarifies previously cryptic aspects of comparative respiratory biology.

Biological models. --- Biological Transport -- Physiology -- Congresses. --- Oxygen -- Metabolism -- Congresses. --- Oxygen -- Physiological transport -- Congresses. --- Oxygen Consumption -- Physiology -- Congresses. --- Pulmonary gas exchange. --- Tissue respiration -- Congresses. --- Pulmonary gas exchange --- Respiration --- Biological Science Disciplines --- Respiratory Transport --- Respiratory Function Tests --- Models, Theoretical --- Respiratory System --- Biological Transport --- Investigative Techniques --- Anatomy --- Natural Science Disciplines --- Diagnostic Techniques, Respiratory System --- Disciplines and Occupations --- Respiratory Physiological Processes --- Metabolism --- Diagnostic Techniques and Procedures --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Respiratory Physiological Phenomena --- Diagnosis --- Metabolic Phenomena --- Phenomena and Processes --- Circulatory and Respiratory Physiological Phenomena --- Lung --- Physiology --- Models, Biological --- Pulmonary Gas Exchange --- Zoology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Anatomy & Embryology --- Respiration. --- Animal respiration --- Animals --- Breathing --- Ventilation (Physiology) --- Gas exchange, Pulmonary --- Pulmonary respiration --- Life sciences. --- Biochemistry. --- Evolutionary biology. --- Animal anatomy. --- Animal physiology. --- Life Sciences. --- Animal Anatomy / Morphology / Histology. --- Animal Physiology. --- Evolutionary Biology. --- Biochemistry, general. --- Vital signs --- Aerobic exercises --- Breathing exercises --- Morphology (Animals). --- Evolution (Biology). --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Animal evolution --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Animal physiology --- Animal morphology --- Body form in animals --- Morphology --- Composition --- Animal anatomy