Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Galanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This 'reverse' approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides. After the structure of galanin was determined in 1983, functional studies were performed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and trophic factor, and is involved in a number of physiological processes such as hormone secretion, cardiovascular mechanisms, feeding and cognition. This peptide may also be of significance for a number of pathological processes/disorders including pain, depression, Alzheimer's disease, epilepsy, addiction and cancer. This wide diversity of actions is mediated by three galanin receptor subtypes. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actions and functions of galanin and its receptors and on possible therapeutic applications in a number of pathological conditions.

Galanin -- Therapeutic use. --- Neuroendocrinology. --- Peptides. --- Galanin --- Neuropeptides --- Peptides --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Animal Biochemistry --- Neuroscience --- Human Anatomy & Physiology --- Health & Biological Sciences --- Galanin. --- Neuropeptides. --- Brain peptides --- Life sciences. --- Neurobiology. --- Life Sciences. --- Nerve tissue proteins --- Neurotransmitters --- Neurosciences

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Physical activity and exercise were receiving a great attention as a strategy of prevention and treatment of affective and some anxiety disorders. Many studies have showed the efficacy of exercise in major depression and at depressed episode of bipolar patients, as well as, some authors shows the benefits of exercise in some anxiety disorders like Generalized Anxiety Disorder and Panic. Despite their efficacy, little is known concerning the main mechanisms related to the antidepressant and anxiolytic effects of exercise. Several studies in an animal model using Neurotrophic Factors, Oxidative Stress, Immunologic response and other biological markers reveal promising results. However, few studies were conducted in clinical samples. Additional to the antidepressant and anxiolytic effects, exercise appears improve QoL in major depressed, bipolar and anxiety patients. Theoretically, this increase may be associated with cognitive improvements, improvements at sleep quality, physical functioning, as well as other psychological issues as self-esteem, self-concept, and general well-being. The propose of this topic is to address the novelty and most recent research, related to antidepressant and anxiolytic effects of physical activity and exercise in patients with affective and anxiety disorders, as well as the issues associated with QoL improvement.The topic is looking for: – Clinical trials using exercise and physical activity as a treatment affective and anxiety disorders. – Studies investigating the optimal prescription factors (dose, volume, intensity, setting, frequency) associated with antidepressant and anxiolytic effects of physical activity and exercise for affective and anxiety disorder patients. – Original studies, comprehensive reviews, hypothesis and opinions concerning the mechanisms of antidepressant and anxiolytic effects of physical activity and exercise in affective and anxiety disorder patients. – Original studies, comprehensive reviews, hypothesis and opinions concerning other benefits of physical activity and exercise like : cognition, weight gain prevention and QoL in affective and anxiety disorder patients. – Translational research. – Studies of cost-efficacy analysis

Meditative movement --- Galanin --- BDNF --- Quality of Life --- Depression --- Anxiety --- bipolar --- genetic marker

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Art --- installations [visual works] --- painting [image-making] --- ecology --- Nature --- sculpting --- biological material --- fauna --- animal material --- taxidermy mounts --- Shonibare, Yinka --- Brooks, David --- Fernandez, Carlee --- Galanin, Nicholas --- Bruyckere, De, Berlinde --- Delvoye, Wim --- Morgan, Polly --- Noble, Tim --- Robinson, Walter --- Tim Noble & Sue Webster --- Webster, Sue --- Zieger, Brigitte --- Idiots --- Elmgreen & Dragset --- Golsteijn, Afke --- Bakker, Floris --- Snæbjörnsdottír/Wilson --- Dion, Mark --- Hirst, Damien --- Shrigley, David --- Furet, François --- Coyne, Petah

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

For centuries books have contained and presented the written words that have allowed humankind to study and interpret the world. As texts have become readily available through different media, contemporary artists have been increasingly exploring the interplay between the function, structure, and format of books. Book Art is a stunning documentation of current art, installation, and design created with and from books. The fascinating range of examples, which is as diverse as books themselves, offers eloquent proof that—despite or because of digital media’s inroads as sources of text information—the book’s legacy as a carrier of ideas and communication is being expanded today.

sculpting --- boekkunst --- hedendaagse kunst --- Graphic arts --- Contemporary [style of art] --- beeldhouwkunst --- Sculpture --- Installations (Art) --- Objets trouvés (Art) --- Livres transformés --- Livres dans l'art --- Installation-art --- Objet de récupération --- Traitement de l'objet --- Altered books --- Books in art --- Sculpture, Modern --- Found objects (Art) --- 82:7 "2000-" --- 7.05 --- Boekdesign ; het boek als interactieve papieren-sculptuur --- Design ; meubels ; gebruiksvoorwerpen --- Materialen ; papier ; boeken --- Sculpturale objecten ; installaties ; gemaakt van boeken en papier --- 7.039 --- Allen Thomas --- Andersen Line --- Andersen Martin --- Barer Cara --- Bean Kyle --- Beube Doug --- Bing Xu --- Bom Michael --- Boyd Jonathan --- Cahill Laura --- Callan Jonathan --- Dale Nicola --- De Rabago J Ignacio Diaz --- Dettmer Brian --- Eliasson Olafur --- Epstein Gene --- Galanin Nicholas --- Hawkins Yvette --- Hay Graham --- Haynes Nicci --- Huang Samantha --- Hybschmann Johan --- Ishiguro Takeshi --- Jokhova Evguenia --- Jones Nicholas --- Kapoor Anish --- Kihara Yoshimi --- Koelewijn Job --- Kokin Lisa --- Krén Matej --- Laramée Guy --- Martin Alicia --- McPherson Steve --- Nendo --- Nobody & Co --- Papuli Daniele --- Porteous Susan --- Rixon Ros --- Rosenau Jim --- Ruff Donna --- Rush lee Jacqueline --- Russell Georgia --- South Twelve --- Stilkey Mike --- Syvänoja Janna --- The Robert --- Wentworth Richard --- boeken --- design --- eenentwintigste eeuw --- installaties --- kunst --- twintigste eeuw --- 684.93 --- Allen, Thomas --- Andersen M --- Barer, Cara --- Bean, Kyle --- Beube, Doug --- Bing, Xu --- Bom, Michael --- Boyd, Jonathan --- Cahill, Laura --- Callan, Jonathan --- Dale, Nicola --- De Rabago, J Ignacio Diaz --- Dettmer, Brian --- Eliasson, Olafur --- Epstein, Gene --- Galanin, Nicholas --- Hawkins, Yvette --- Hay, Graham --- Haynes, Nicci --- Huang, Samantha --- Hybschmann, Johan --- Ishiguro, Takeshi --- Jokhova, Evguenia --- Jones, Nicholas --- Kapoor, Anish --- Kihara, Yoshimi --- Koelewijn, Job --- Kokin, Lisa --- Krén, Matej --- Laramée, Guy --- Martin, Alicia --- McPherson, Steve --- Nobody&Co --- Papuli, Daniele --- Porteous, Susan --- Rixon, Ros --- Rosenau, Jim --- Ruff, Donna --- Rush Lee, Jacqueline --- Russell, Georgia --- Stilkey, Mike --- Syvänoja, Janna --- The, Robert --- Twelve south --- Wentworth, Richard --- conceptuele kunst --- productdesign --- Literatuur en kunst--"2000-"--Vanaf het jaar 2000. Toekomst--(variabel) --- Kunst ; het boek als kunstobject ; Kunstenaarsboeken, geïllustreerde boeken, boekbanden --- het boek, boekkunst --- Installation art --- Art, Modern --- Environment (Art) --- Found art --- Objects, Found (Art) --- Ready-mades (Art) --- Readymades (Art) --- Altered book art --- Books --- Collage --- Sculpture - 21e siècle --- Sculpture, Modern - 20th century

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

In recent years, peptides have received increased interest from the pharmaceutical industry. The high potency, specificity, and safety profile are the main strengths of bioactive peptides as new and promising therapies that may fill the gap between small molecules and protein drugs. These positive attributes have renewed interest in the discovery, optimization, and development of peptides as pharmacological therapy. Among bioactive peptides, those released from food sources have acquired importance as nutraceutical and active components in functional foods because they possess regulatory functions that can lead to health benefits. This Special Issue covers a selection of recent research papers and reviews in the field of bioactive peptides. It covers all aspects of peptide research in relation to health promotion. In particular, it emphasizes current knowledge and research trends concerning bioactive peptides, including identification and quantification of peptides from new sources, methods for their production and purification, structure–function relationships, mechanisms of action, in vitro and in vivo assays for the evaluation of their bioactivity, physiological evidence to support health benefits, and peptide stability and bioavailability. Papers regarding the development of new drugs, functional foods, or nutraceuticals based on bioactive peptides were also considered.

Research & information: general --- Biology, life sciences --- antihypertensive peptides --- functional food --- food-derived --- fermentation --- Chlorella sorokiniana --- in silico --- BIOPEP-UWM database --- proteomics --- bioactive peptides --- nano liquid chromatography tandem mass spectrometry (nanoLC–nanoESI MS/MS) --- apolipoprotein E --- amyloid fibrils --- Alzheimer’s disease --- Αβ oligomer --- amyloid --- Aβ peptide --- glioma --- platelets --- antiproliferative assay --- conjugation --- docetaxel --- doxorubicin --- extra domain B --- fibronectin --- Fmoc/tBu --- peptide–drug conjugate --- prostate cancer --- solid-phase synthesis --- targeting --- acrylamide --- enteric nervous system --- galanin --- pig --- stomach --- formyl peptide receptors --- ligands --- diseases --- polymicrobial biofilms --- intragenic antimicrobial peptide --- Hs02 --- Pseudomonas aeruginosa --- Staphylococcus aureus --- osteostatin --- arthritis --- inflammation --- immune response --- cartilage destruction --- bone erosion --- collagen --- hydrolysis --- enzyme --- molecular weight --- sheepskin --- NF-κB --- dry-cured pork ham --- angiotensin I converting enzyme --- endothelial dysfunction --- molecular blind docking --- Lactoferricin B (Lfcin B) --- Histatin-5 --- antimicrobial peptides (AMPs) --- antifungal activity --- proteome microarray --- synergy --- temporin --- MRSA --- antimicrobial peptide --- human keratinocytes --- pseudin-2 --- antisepsis, peptide antibiotics --- neurotensin --- asthma --- T cells --- In situ tetramer staining --- MHC tetramer --- antigen-specific --- confocal microscopy --- fresh tissue --- velvet antler --- alcalase hydrolysate --- antioxidant peptide --- protection ability --- oxidative stress --- Crassostrea angulata --- pidotimod --- CXCR3 --- monocyte --- migration --- PI3K/Akt pathway --- T cell --- immunomodulant --- host defense peptides --- membrane activity --- copper --- piscidins --- Clostridioides difficile --- prolactin-releasing peptide --- GPR10 --- RF-amide peptides --- food intake regulation --- energy expenditure --- neuroprotection --- signaling --- gender differences --- dyslipidemia --- obesity --- hyperglycemia --- pulmonary emphysema --- endothelial progenitor cells --- angiogenic precursor cells --- pegylated glucagon-like peptide 1 --- and endothelial regeneration --- miiuy croaker (Miichthys miiuy) --- swim bladder --- FPYLRH --- antioxidant activity --- cytoprotective effect --- antimicrobial peptides --- antimicrobial resistance --- AMP identification and design --- biosynthesis --- mode of action --- physico-chemical properties --- therapeutic potential --- insects --- Cecropins --- Cec-analogs --- MDR infectious diseases --- airway inflammation --- non-atopic asthma --- hybrid peptide --- pro-inflammatory cytokines --- sPLA2 --- MDA --- database --- proteolysis --- SMILES code --- foods --- nutrition --- chronic diseases --- nutraceuticals --- peptide vaccine --- immune checkpoint inhibitor --- humanized mouse --- cancer antigen --- immune suppression --- vasoactive intestinal peptide --- VPAC1 receptor --- VPAC2 receptor --- rheumatic diseases --- inflammatory bowel disease --- central nervous system diseases --- type 1 diabetes --- Sjögren’s syndrome --- biomarkers --- human antimicrobial peptides --- defensins --- cathelicidins --- anti-inflammatory --- pro-inflammatory --- peptide --- combinatorial library --- library design --- screening --- mutagenesis --- prolyl-hydroxyproline (Pro-Hyp) --- hydroxyprolyl-glycine (Hyp-Gly) --- collagen peptide --- fibroblasts --- fetal bovine serum (FBS) --- AMD --- CNV --- VEGFR1 --- multimeric peptides --- oral delivery --- colorectal cancer --- cancer stem cells --- chemoprevention --- bioactive peptide --- lunasin --- ACE-inhibitory activity --- whey peptides --- molecular docking --- hypertension --- antibiotic resistance --- cystic fibrosis --- cryptides --- anti-biofilm peptides --- synergistic effects --- n/a --- nano liquid chromatography tandem mass spectrometry (nanoLC-nanoESI MS/MS) --- Alzheimer's disease --- peptide-drug conjugate --- Sjögren's syndrome