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Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. First, their frequent mutational activation in human cancers establishes Ras proteins as important mediators of oncogenesis and targets for anti-cancer drug discovery. Second, Ras proteins act as signalling nodes activated by diverse extracellular stimuli, and activated Ras in turn regulates a diversity of cytoplasmic signalling networks. Third, Ras proteins are founding members of a large superfamily of Ras-related small GTPases. Over 150 Ras-related small GTPases are found in the human genome, with orthologs found in all vertebrate species and invertebrates. This book features chapters by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.

GTPase-activating protein. --- Guanosine triphosphatase genes. --- Guanosine triphosphatase. --- Ras oncogenes. --- Ras proteins. --- G proteins --- Guanosine triphosphatase --- GAP (Protein) --- Proteins --- Ras genes --- Guanosine triphosphatase genes --- Oncogenes --- GTP phosphohydrolase --- GTPase --- Guanosine triphosphate phosphohydrolase --- Guanosinetriphosphatase --- Phosphatases --- Genes

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This volume is an in-depth treatment of G-Protein Signaling, Part A, and will cover general methods of analysis of RGS protein analysis, including Expression and post-translational modification, Assays of GAP activity and allosteric control, Electrophysiological methods and RGS-insensitive Ga subunits, Mouse models of RGS protein action, Methods of RGS protein inhibition, and G-protein regulators of model organisms.Table of Contents-Expression and post-translational modification-Assays of GAP activity and allosteric control-Electrophysiological methods and RGS-insenstitive

Biochemistry -- Periodicals. --- Biochemistry -- Technique. --- Enzymes -- Periodicals. --- Enzymes. --- G proteins. --- RGS Proteins. --- Intracellular Signaling Peptides and Proteins --- RGS Proteins --- GTP-Binding Protein Regulators --- GTPase-Activating Proteins --- Proteins --- Peptides --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Polypeptides --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Regulating Factors, G-Protein --- Regulating Factors, GTP-Binding Protein --- G-Protein Regulating Factors --- G-Protein Signaling Regulators --- Regulators, G-Protein Signaling --- G Protein Regulating Factors --- G Protein Signaling Regulators --- GTP Binding Protein Regulators --- Regulating Factors, GTP Binding Protein --- Regulators, G Protein Signaling --- Regulators, GTP-Binding Protein --- Signaling Regulators, G-Protein --- Intracellular Signaling Peptides --- Intracellular Signaling Proteins --- Peptides, Intracellular Signaling --- Proteins, Intracellular Signaling --- Signaling Peptides, Intracellular --- Signaling Proteins, Intracellular --- GAP Protein --- GTPase-Activating Protein --- GAP Proteins --- GTPase Activating Protein --- GTPase Activating Proteins --- RGS Protein (G-Protein Signaling) --- Regulators of G-Protein Signaling Proteins --- Regulators of G Protein Signaling Proteins --- Cell physiology. --- Cellular control mechanisms. --- Proteins. --- Stress (Physiology). --- Molecular Mechanisms of Pharmacological Action --- Peptide --- Polypeptide --- Protein --- Membrane proteins.