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Carcinogenesis --- Active oxygen - Pathophysiology. --- Carcinogenesis. --- Cardiovascular system - Pathophysiology. --- Free radicals (Chemistry) - Pathophysiology.

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Antioxidants --- Oxidative Stress --- Reactive Oxygen Species --- Biological Markers --- therapeutic use --- diagnostic use --- Therapeutic use --- Congresses --- Free radicals (Chemistry) --- Pathophysiology --- Analysis --- Free radicals (Chemistry) - Pathophysiology - Congresses. --- Free radicals (Chemistry) - Analysis - Congresses. --- Antioxidants - Therpaeutic use - Congresses. --- FREE RADICALS (MEDICINE) --- ANTIOXIDANTS --- LIPIDS --- FREE RADICALS --- REACTIONS

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Biopharmaco-efficiency. Pharmacokinetics --- Free radicals (Chemistry) --- Oxidative stress --- Air --- Food additives --- Air Pollution --- Food Additives --- Free Radicals --- Pathophysiology --- Pollution --- Physiological effect --- congresses. --- General biochemistry --- Drugs --- Congresses. --- Free radicals (Chemistry) - Pathophysiology - Congresses. --- Oxidative stress - Pathophysiology - Congresses. --- Air - Pollution - Congresses. --- Drugs - Physiological effect - Congresses. --- Food additives - Congresses. --- Air Pollution - congresses --- Food Additives - congresses. --- Free Radicals - congresses --- RADICALS (CHEMISTRY) --- ENVIRONMENT --- OXIDATIVE STRESS, BIOLOGICAL --- PHARMACEUTICAL PREPARATIONS --- FOOD ADDITIVES --- ANTIOXIDANTS --- BIOLOGICAL STUDIES

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The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consist of brief reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with migraine. With luck they may also find information on the purported role of free radicals in the pathogenesis of traumatic brain injury. Oxidative Stress and Free Radical Damage in Neurology sets the record straight, focusing on clinical and research issues regarding the interplay of free radicals and the human nervous system. Crucially, the chapters cover numerous antioxidants and their possible therapeutic role in neurological disorders. Key illnesses such as epilepsy, multiple sclerosis and Parkinson’s are analyzed, and chapters also examine more general issues such as the link between free radicals and inflammation of the central nervous system. Clinicians and laboratory researchers alike will find that this book augments their understanding not only of the widespread involvement of free radicals in the central nervous system but also of some uncertainties surrounding whether free radical damage in neurology plays a primary or secondary role.

Free radicals (Chemistry) -- Pathophysiology. --- Nervous system -- Diseases -- Etiology. --- Oxidative stress. --- Oxidative stress --- Free radicals (Chemistry) --- Nervous system --- Organic Chemicals --- Diseases --- Stress, Physiological --- Central Nervous System Diseases --- Metabolism --- Inorganic Chemicals --- Metabolic Phenomena --- Chemicals and Drugs --- Physiological Processes --- Nervous System Diseases --- Brain Diseases --- Oxidative Stress --- Free Radicals --- Physiological Phenomena --- Phenomena and Processes --- Medicine --- Health & Biological Sciences --- Neurology --- Pathology --- Pathophysiology --- Etiology --- Neurology. --- Medicine. --- Molecular biology. --- Neurosciences. --- Cell biology. --- Biomedicine. --- Cell Biology. --- Molecular Medicine. --- Neuropsychiatry --- Oxidation-reduction reaction --- Stress (Physiology) --- Cytology. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Neural sciences --- Neurological sciences --- Neuroscience --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology

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Oxidative stress has been linked to a variety of medical problems, including cardiovascular disease, cancer, arthritis, diabetes, and aging. Drawing on the growing volume of research into the impact of oxidative stress on pathophysiological mechanisms, Donald Armstrong updates and expands his highly praised Free Radical and Antioxidant Protocols (Humana, 1998) with a collection of new and valuable methods for evaluating the perturbations in cell function resulting from increased oxidative stress. Presented in a user-friendly, step-by-step format by accomplished investigators from prestigious universities, institutes, and laboratories around the world, these readily reproducible techniques cover both free radical-derived and antioxidant biomarkers. The methodologies demonstrated include ELISA, HPLC, infrared spectroscopy, gas chromatography-mass spectroscopy, immunoblotting, electroelution fractionation, isoelectric focusing, voltammetry, and electron paramagnetic resonance imaging. Special emphasis is given to the separation of complex mixtures of plant antioxidants, soft drug design to protect from toxic oxidative metabolites, in vitro oxidation conditions, and correcting for random measurement error to improve statistical interpretation. A soon-to-be-published companion volume, Oxidants and Antioxidants: Ultrastructure and Molecular Biology Protocols (Humana, 2002), contains state-of-the-art molecular and ultrastructural methods that expand the total number of protocols to 109 assays. Cutting-edge and highly practical, Oxidative Stress Biomarkers and Antioxidant Protocols provides many powerful new tools for detecting oxidative stress and for investigating the possibilities for therapeutic intervention monitoring in a variety of serious diseases.

Molecular biology --- Antioxidants -- Physiological effect -- Laboratory manuals. --- Electronic books. -- local. --- Free radicals (Chemistry) -- Pathophysiology -- Laboratory manuals. --- Oxidation, Physiological -- Laboratory manuals. --- Stress (Physiology) -- Research -- Laboratory manuals. --- Free radicals (Chemistry) --- Antioxidants --- Oxidative stress --- Free Radicals --- Oxidative Stress --- Protective Agents --- Molecular Mechanisms of Pharmacological Action --- Stress, Physiological --- Inorganic Chemicals --- Organic Chemicals --- Metabolism --- Chemicals and Drugs --- Metabolic Phenomena --- Physiological Effects of Drugs --- Pharmacologic Actions --- Physiological Processes --- Specialty Uses of Chemicals --- Chemical Actions and Uses --- Physiological Phenomena --- Phenomena and Processes --- Biology - General --- Pathology --- Biochemistry --- Biology --- Chemistry --- Medicine --- Physical Sciences & Mathematics --- Health & Biological Sciences --- Pathophysiology --- Physiological effect --- Research --- Oxidation, Physiological --- Stress (Physiology) --- Physiological stress --- Tension (Physiology) --- Adaptation (Biology) --- Biological oxidation --- Oxidation, Biological --- Physiological oxidation --- Chemical inhibitors --- Radicals (Chemistry) --- Free radical reactions --- Biochemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Medical sciences --- Composition