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Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in some foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Integrated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process--

Formaldehyde - toxicity - United States. --- Formaldehyde --- North America --- Risk Management --- Risk --- Aldehydes --- Epidemiologic Measurements --- Biological Science Disciplines --- Environmental Pollution --- Public Health --- Americas --- Natural Science Disciplines --- Organization and Administration --- Probability --- Organic Chemicals --- Chemicals and Drugs --- Health Services Administration --- Geographic Locations --- Disciplines and Occupations --- Environment and Public Health --- Statistics as Topic --- Health Care --- Epidemiologic Methods --- Health Care Evaluation Mechanisms --- Geographicals --- Quality of Health Care --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Health Care Quality, Access, and Evaluation --- Risk Assessment --- United States --- Environmental Exposure --- Pharmacology --- Health & Biological Sciences --- Toxicology & Public Health --- Toxicology --- Risk assessment --- Risk assessment. --- Toxicology. --- United States.