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Protein folding. --- Protein Folding. --- Protein Folding, Globular --- Folding, Globular Protein --- Folding, Protein --- Foldings, Globular Protein --- Foldings, Protein --- Globular Protein Folding --- Globular Protein Foldings --- Protein Foldings --- Protein Foldings, Globular --- Proteostasis --- Protein Multimerization --- Intrinsically Disordered Proteins --- Folding of proteins --- Proteins --- Folding --- Conformation
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Protein folding --- Protein Folding. --- 577.122 --- Folding of proteins --- Proteins --- Protein Folding, Globular --- Folding, Globular Protein --- Folding, Protein --- Foldings, Globular Protein --- Foldings, Protein --- Globular Protein Folding --- Globular Protein Foldings --- Protein Foldings --- Protein Foldings, Globular --- Protein Multimerization --- Intrinsically Disordered Proteins --- Protein metabolism --- Folding --- Conformation --- 577.122 Protein metabolism --- Protein Folding --- Proteostasis --- Protein folding. --- Kinetics
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The past five years have seen a major leap forward in our understanding of the way proteins fold into their three-dimensional, functional conformations. The rapidly expanding literature covers in vivo as well as in vitro studies and forms the basis for an important biotechnology industry. In this volume, a group of leading scientists review and assess the experimental evidence that underpins these advances and look for signs of a general picture of how proteins fold. Contributors show how such conformational changes are leading to new insights into membrane translocation, pore formation, and the clinically important aggregation phenomena. Students and researchers of biochemistry and molecular biology will find this book to be the ideal introduction to an exciting field.
General biophysics --- Molecular biology --- Macromolecules --- Protein folding --- Protéines --- Repliement --- Protein Folding. --- Folding of proteins --- Proteins --- Protein Folding, Globular --- Folding, Globular Protein --- Folding, Protein --- Foldings, Globular Protein --- Foldings, Protein --- Globular Protein Folding --- Globular Protein Foldings --- Protein Foldings --- Protein Foldings, Globular --- Protein Multimerization --- Intrinsically Disordered Proteins --- Folding --- Conformation --- Protein folding. --- Protéines --- Protein Folding --- Proteostasis --- fysicochemie
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Prions --- Protein folding --- Prions. --- Protein folding. --- Folding of proteins --- Proteins --- Infectious protein particles --- Prion proteins --- Protein particles, Infectious --- Proteinaceous infection particles --- PrP proteins --- Folding --- Protein Folding --- Conformation --- Protein Folding, Globular --- Folding, Globular Protein --- Folding, Protein --- Foldings, Globular Protein --- Foldings, Protein --- Globular Protein Folding --- Globular Protein Foldings --- Protein Foldings --- Protein Foldings, Globular --- Proteostasis --- Protein Multimerization --- Intrinsically Disordered Proteins --- Mink Encephalopathy Virus --- Encephalopathy Virus, Mink --- Scrapie --- Agriculture Sciences --- Soil Chemistry, Microbiology, Fertility & Fertilizers --- Prion --- protein folding --- protein assembly disorders --- prion diseases --- prions --- Protein Folding.
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With the huge increase in available data on the DNA sequences of proteins, there is a growing need to understand and characterize how proteins fold into their biologically active native states and the basis for the stability of these states. In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating aspects of protein stability and dynamics from knowledge of the structure, for calculating conformational entropy, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of this complex area by detailing many of the major innovative techniques in use today.
Protein folding. --- Proteins --- Conformation. --- Protein conformation --- Folding of proteins --- Folding --- Conformation --- Biochemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Protein folding --- Protein Conformation --- Protein Folding --- Structure-Activity Relationship --- 577.122 --- Protein Folding, Globular --- Folding, Globular Protein --- Folding, Protein --- Foldings, Globular Protein --- Foldings, Protein --- Globular Protein Folding --- Globular Protein Foldings --- Protein Foldings --- Protein Foldings, Globular --- Proteostasis --- Protein Multimerization --- Intrinsically Disordered Proteins --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- 577.122 Protein metabolism --- Protein metabolism --- Relationship, Structure-Activity --- Relationships, Structure-Activity --- Structure Activity Relationship --- Structure-Activity Relationships --- chemistry --- PROTEINS --- PROTEIN FOLDING --- CONFORMATION
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Protein Folding Protocols presents protocols for studying and characterizing protein folding from the unfolded to the folded state. Covering experiment and theory, bioinformatics approaches, and state-of-the-art simulation protocols for better sampling of the conformational space, this volume describes a broad range of techniques to study, predict, and analyze the protein folding process. Protein Folding Protocols also provides sample approaches toward the prediction of protein structure starting from the amino acid sequence, in the absence of overall homologous sequences. These approaches have tremendous implications, ranging from drug design, functional assignment, comprehension of the nature of regulation, understanding molecular machines, viral entry into cells, and putting together cellular pathways and their dynamics.
Protein folding. --- Proteins --- Conformation. --- Analysis. --- Protein conformation --- Folding of proteins --- Folding --- Proteins -- Analysis. --- Protein folding --- Biophysical Processes --- Biophysical Phenomena --- Conformation --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Protein Folding --- Protein Conformation --- 577.122 --- 577.122 Protein metabolism --- Protein metabolism --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- Protein Folding, Globular --- Folding, Globular Protein --- Folding, Protein --- Foldings, Globular Protein --- Foldings, Protein --- Globular Protein Folding --- Globular Protein Foldings --- Protein Foldings --- Protein Foldings, Globular --- Proteostasis --- Protein Multimerization --- Intrinsically Disordered Proteins --- Analysis --- analysis --- PROTEINS --- PROTEIN FOLDING --- ANALYSIS --- CONFORMATION
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Recent major advances in our understanding of modulating protein functions has led to the development of new methods and algorithms to predict and decipher how amino acid sequences shape three-dimensional structures. Protein Design: Methods and Applications presents the most up-to-date protein design and engineering strategies so that readers can undertake their own projects with a maximum chance of success. The authors present integrated computational approaches that require various degrees of computational complexity, and the major accomplishments that have been achieved in the design and structural characterization of helical peptides and proteins. Other topics of discussion include: design of structural elementary motifs, entire proteins, and interfaces of protein complexes, and of amyloidogenic polypeptides and amyloid inhibitors. Authoritative and cutting-edge, Protein Design: Methods and Applications will be of major interest to protein scientists, biochemists, and all experimentalists selecting the strategy most adaptable for their design problem.
Protein engineering --- Protein Engineering --- Proteins --- Protein Conformation --- Protein Folding --- methods --- chemistry --- Protein engineering. --- Biophysical Processes --- Biophysical Phenomena --- Engineering, Protein --- Protein design --- Proteins. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Biochemical engineering --- Genetic engineering --- Design --- Biochemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- 577.122 --- 577.122 Protein metabolism --- Protein metabolism --- Protein Folding, Globular --- Folding, Globular Protein --- Folding, Protein --- Foldings, Globular Protein --- Foldings, Protein --- Globular Protein Folding --- Globular Protein Foldings --- Protein Foldings --- Protein Foldings, Globular --- Proteostasis --- Protein Multimerization --- Intrinsically Disordered Proteins --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- Protein Engineering - methods --- Proteins - chemistry
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Protein folding --- RNA --- Biomolecules --- Protein Engineering. --- Protein Folding. --- Proteins --- Protéines --- ARN --- Biomolécules --- Conformation --- Design --- analysis. --- Repliement --- Protein Folding, Globular --- Folding, Globular Protein --- Folding, Protein --- Foldings, Globular Protein --- Foldings, Protein --- Globular Protein Folding --- Globular Protein Foldings --- Protein Foldings --- Protein Foldings, Globular --- Genetic Engineering, Protein --- Proteins, Genetic Engineering --- Genetic Engineering of Proteins --- Engineering, Protein --- Engineering, Protein Genetic --- Protein Genetic Engineering --- Biological molecules --- Ribonucleic acid --- Ribose nucleic acid --- Folding of proteins --- Folding --- Protein Engineering --- Protein Folding --- analysis --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Molecular Mechanisms of Pharmacological Action --- Proteostasis --- Protein Multimerization --- Intrinsically Disordered Proteins --- Genetic Engineering --- Directed Molecular Evolution --- DNA Shuffling --- Molecular Farming --- Molecules --- Molecular biology --- Nucleic acids --- Ribose --- Protéines --- Biomolécules --- Protein folding. --- Protein --- Protein engineering. --- Technologie des protéines. --- Protein design --- Biochemical engineering --- Genetic engineering --- Conformació de proteïnes. --- Enginyeria de proteïnes. --- Revistes electròniques. --- Enginyeria de proteïnes --- Proteïnes --- Biomolècules --- Anàlisi --- Disseny --- Conformació --- Technologie des protéines. --- Enginyeria de proteïnes --- Anàlisi --- Conformació
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Protein Conformation. --- Protein Denaturation. --- Protein Folding. --- Structure-Activity Relationship. --- Proteins --- Protéines --- Pathophysiology. --- Structure-activity relationships. --- Metabolism --- Disorders. --- Physiopathologie --- Pathophysiology --- Structure-activity relationships --- Disorders --- Protéines --- Protein Conformation --- Protein Denaturation --- Protein Folding --- Structure-Activity Relationship --- 577.122 --- 577.122 Protein metabolism --- Protein metabolism --- Relationship, Structure-Activity --- Relationships, Structure-Activity --- Structure Activity Relationship --- Structure-Activity Relationships --- Protein Folding, Globular --- Folding, Globular Protein --- Folding, Protein --- Foldings, Globular Protein --- Foldings, Protein --- Globular Protein Folding --- Globular Protein Foldings --- Protein Foldings --- Protein Foldings, Globular --- Proteostasis --- Protein Multimerization --- Intrinsically Disordered Proteins --- Denaturation, Protein --- Denaturations, Protein --- Protein Denaturations --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Metabolism&delete& --- Protein metabolism disorders --- Proteins - Pathophysiology --- Proteins - Structure-activity relationships --- Proteins - Metabolism - Disorders
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"An important textbook for undergraduate and graduate students in structural biology, chemistry, biochemistry, biology and medicine. Written by a team of leading scientists in the field, it covers all the essential aspects of proteins, nucleic acids and lipids, including the rise and fall of proteins, membranes and gradients, the structural biology of cells, and evolution -- the comparative structural biology. The focus is on interesting and relevant molecular structures as well as central biology"--Back cover.
Biomolecules --- Cell Communication. --- Cells --- Protein Folding. --- Protein folding. --- Proteins --- Proteins. --- Ultrastructure (Biology). --- Structure. --- cytology. --- Cytology. --- Ultrastructure (Biology) --- Protein folding --- Structure --- Protéines --- Protein Folding --- Cell Communication --- 577.1 --- Protein Folding, Globular --- Folding, Globular Protein --- Folding, Protein --- Foldings, Globular Protein --- Foldings, Protein --- Globular Protein Folding --- Globular Protein Foldings --- Protein Foldings --- Protein Foldings, Globular --- Proteostasis --- Protein Multimerization --- Intrinsically Disordered Proteins --- 577.1 Chemical bases of life. Biochemistry and bio-organic chemistry generally --- Chemical bases of life. Biochemistry and bio-organic chemistry generally --- Cell Interaction --- Cell-to-Cell Interaction --- Cell Communications --- Cell Interactions --- Cell to Cell Interaction --- Cell-to-Cell Interactions --- Communication, Cell --- Communications, Cell --- Interaction, Cell --- Interaction, Cell-to-Cell --- Interactions, Cell --- Interactions, Cell-to-Cell --- Gene Products, Protein --- Gene Proteins --- Protein --- Protein Gene Products --- Proteins, Gene --- Molecular Mechanisms of Pharmacological Action --- Biological molecules --- Molecules --- Molecular biology --- Folding of proteins --- Fine structure (Biology) --- Nanobiology --- Microstructure --- Nanoscience --- cytology --- Folding --- Conformation --- Proteins - Structure --- Biomolecules - Structure --- Protéines
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