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Fish oils --- Fish oils in human nutrition

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Annotation The role of major dietary omega-3 fatty acids (-3; -linolenic acid, eicosapentaenoic acid and docosahexaenoic acid) in human health has generated enormous scientific interest and many controversies in recent years. Due to a growing number of studies with conflicting or even negative clinical results, the former "hype" of -3 thought to be beneficial in many aspects of human health regardless of the physiological and clinical preconditions is now being critically re-evaluated, especially with respect to the potential role of -3 fatty acid supplementation in preventing a variety of diseases and clinical conditions. This critical view reflects the complex interaction of -3 with cell membranes and their integrated proteins mediating signal transduction, transport systems, and other processes. Moreover, -3 are precursors of bioactive metabolites, such as eicosanoids, lipoxins, resolvins, protectins, maresins, and nitrolipids that influence several physiological and pathophysiological processes and their full spectrum of effects are only beginning to be defined. Finally, physiological and pathophysiological conditions as well as concomitant pharmacological treatments may influence the specific and non-specific actions of -3 supplementation.This Special Issue of the Journal of Clinical Medicine will emphasize the role and biological interactions of -3 with regard to cancer, psychiatric disorders, metabolic disorders and nutrition and will also reflect on some basic molecular and cellular mechanisms.

Fish oils in human nutrition. --- Omega-3 fatty acids.

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Omega-3 fatty acids --- Omega-3 fatty acids --- Fish oils in human nutrition.

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It is becoming increasingly evident that the deficiency of n-3 fatty acids in diet is not only associated with cardiovascular diseases, but also involved in stroke, epilepsy and other neurological and neurodegenerative diseases, such as Alzheimer disease, Parkinson disease, and peroxisomal diseases. In his newest book, Beneficial Effects of Fish Oil on Human Brain, Dr. Akhlaq A. Farooqui expands on the status and therapeutic importance of n-3 fatty acids (major components of fish oil) and their mediators in normal brain and those with neurodegenerative and neuropsychiatric diseases. Farooqui presents the benefits of n-3 fatty acids on Western diet, which is enriched in n-6 fatty acids (major components of vegetable oil) and may promote the above neurological disorders. The book will present readers with cutting edge and comprehensive information on metabolism and roles of neural membrane n-3 fatty acids. Neuroscientists, clinicians, neurologists, neuropathologists, opthamologists, dietitians, and nutritionists will find this book useful for understanding the molecular basis of n-3 fatty acids and their lipid mediators (resolvins and neuroprotectins) in neuroprotection in acute neural trauma (stroke, spinal cord trauma and head injury) and neurodegenerative diseases. About the Author: Dr. Akhlaq A. Farooqui is a leader in the field of brain phospholipases A2, bioactive ether lipid metabolism, polyunsaturated fatty acid metabolism, glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, and glutamate-induced neurotoxicity. He has discovered the stimulation of plasmalogen-selective phospholipase A2 (PlsEtn-PLA2) and diacyl- and monoacylglycerol lipases in brains from patients with Alzheimer disease. Stimulation of PlsEtn-PLA2 produces plasmalogen deficiency and increases levels of eicosanoids that may be related to the loss of synapses in brains of patients with Alzheimer disease. Dr. Farooqui has published cutting edge research on the generation and identification of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid neurotoxicity by lipidomics. He has previously authored four monographs: Glycerophospholipids in Brain: Phospholipase A2 in Neurological Disorders (2007); Neurochemical Aspects of Excitotoxicity (2008); Metabolism and Functions of Bioactive Ether Lipids in Brain (2008); and Hot Topics in Neural Membrane Lipidology (2009). All monographs are published by Springer.

Brain --Diseases --Nutritional aspects. --- Fish oils --Health aspects. --- Fish oils in human nutrition. --- Fish oils --Physiological effect. --- Omega-3 fatty acids --Health aspects. --- Fish oils in human nutrition --- Fish oils --- Omega-3 fatty acids --- Brain --- Central Nervous System --- Fatty Acids, Unsaturated --- Dietary Fats, Unsaturated --- Oils --- Nervous System --- Dietary Fats --- Fatty Acids --- Lipids --- Fats --- Anatomy --- Chemicals and Drugs --- Fish Oils --- Fatty Acids, Omega-3 --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Neuroscience --- Health aspects --- Nutritional aspects --- Diseases --- Physiological effect --- Nutritional aspects. --- Health aspects. --- Physiological effect. --- N-3 fatty acids --- Omega-3 EFA --- Omega-3 essential fatty acids --- Fish liver oils --- Fish-oil --- Cerebrum --- Mind --- Medicine. --- Neurosciences. --- Neurochemistry. --- Clinical nutrition. --- Neurology. --- Biomedicine. --- Clinical Nutrition. --- Unsaturated fatty acids --- High-omega-3 fatty acid diet --- Fishery products --- Marine animal oils --- Nutrition --- Central nervous system --- Head --- Personal health and hygiene. --- Medicine --- Nervous system --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Medical sciences --- Biochemistry --- Neurosciences --- Neurology . --- Clinical nutrition --- Diet --- Diet and disease --- Dietotherapy --- Food --- Medical nutrition therapy --- MNT (Medical nutrition therapy) --- Nutrition therapy --- Dietetics --- Therapeutics, Physiological --- Therapeutic use