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Crohn Disease --- Antibodies, Monoclonal --- Gastrointestinal Agents --- Intestinal Fistula --- Fibroblast Growth Factor 2 --- drug therapy. --- therapeutic use. --- complications. --- blood. --- Theses --- drug therapy --- therapeutic use --- complications --- blood

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The regenerative and immunomodulatory properties of mesenchymal stem cells (MSCs) have made these cells the focus of multiple pre-clinical studies and clinical trials. While the results from these clinical studies have established that MSCs are safe, the efficacy of these cells is not as well-established. In this regard, there have been increased efforts towards generating potentiated/activated MSCs with enhanced therapeutic efficacy. Research on the mechanisms for enhancing MSC potency and efficacy is an area of active study with great potential for translation into clinical settings. The purpose of this book is to bring together recent research from a broad range of topics relating to potentiation strategies for enhancing MSC therapeutic efficacy, including growth factor pre-conditioning, hypoxia, and 3D culture. The research compiled in this book increases the basic understanding of MSC culture techniques and describes some MSC preparations for potential novel therapeutic applications.

Medicine --- cell therapy --- immunomodulation --- polyunsaturated fatty acid --- CD206 --- phagocytosis --- mesenchymal stem cells --- Vadadustat --- AKB-6548 --- preconditioning --- priming --- secretome --- chemotaxis --- Wharton’s jelly mesenchymal stem cells --- umbilical cord --- oxygen conditions --- secretory profile --- neuroprotection --- mesenchymal stromal cells --- 3D culture --- neurospheres --- spheroids --- pluripotency --- neural --- quiescence --- mesothelioma --- malignant pleural mesothelioma (MPM) --- liver cirrhosis --- placenta-derived mesenchymal stem cells --- WKYMVm --- combination therapy --- iPSC-derived MSCs --- iMSC secretome --- pre-conditioning --- angiogenesis --- IFN-γ --- hypoxia --- potentiation of iMSC efficacy --- nanofiber-hydrogel composite --- spinal cord injury --- inflammation --- macrophages --- secondary injury --- astrocytes --- axon growth --- adipose tissue-derived stem cells (ASCs) --- autophagy --- rapamycin --- 3-methyladenine --- immunosuppression --- exosome --- engineered cardiac patches --- adipose-derived stem cell --- paracrine potential --- osteogenic differentiation --- hepatocyte growth factor --- fibroblast growth factor 2 --- cell therapy --- immunomodulation --- polyunsaturated fatty acid --- CD206 --- phagocytosis --- mesenchymal stem cells --- Vadadustat --- AKB-6548 --- preconditioning --- priming --- secretome --- chemotaxis --- Wharton’s jelly mesenchymal stem cells --- umbilical cord --- oxygen conditions --- secretory profile --- neuroprotection --- mesenchymal stromal cells --- 3D culture --- neurospheres --- spheroids --- pluripotency --- neural --- quiescence --- mesothelioma --- malignant pleural mesothelioma (MPM) --- liver cirrhosis --- placenta-derived mesenchymal stem cells --- WKYMVm --- combination therapy --- iPSC-derived MSCs --- iMSC secretome --- pre-conditioning --- angiogenesis --- IFN-γ --- hypoxia --- potentiation of iMSC efficacy --- nanofiber-hydrogel composite --- spinal cord injury --- inflammation --- macrophages --- secondary injury --- astrocytes --- axon growth --- adipose tissue-derived stem cells (ASCs) --- autophagy --- rapamycin --- 3-methyladenine --- immunosuppression --- exosome --- engineered cardiac patches --- adipose-derived stem cell --- paracrine potential --- osteogenic differentiation --- hepatocyte growth factor --- fibroblast growth factor 2

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Fucoidans are a group of fucose-containing sulfated polysaccharides found in many species of brown seaweeds, with numerous bioactive properties. As a highly bioactive seaweed substance with many promising physiological activities, fucoidans have attracted attention from many industries all over the world. Even though fucoidans are a rich source of bioactive properties, the structural properties and bioactive mechanisms of fucoidans are poorly understood. Therefore, novel studies that either characterize the physical properties or biological activities of fucoidans will fill the knowledge gap between industrial applications and the scientific background of those applications. Both purified and partially purified fucoidans isolated from brown seaweeds present high potential as preventative and therapeutic agents against number of chronic diseases, due to their anti-inflammatory, antioxidant, anticancer, neuroprotective, antiviral, antimicrobial, and anticoagulative properties. This Special Issue is aimed at presenting updated information on well-documented studies of the structural characterization and major biological actions relevant for medical, cosmeceutical, and pharmaceutical applications that fucoidans isolated from brown seaweed can offer.

fucoidan --- low-molecular-weight fucoidan --- adriamycin --- nephrotic syndrome --- psoriasis --- Traf3ip2 --- microbiota --- mucin --- IgA --- fucoidans --- extraction --- brown algae --- production --- bioactivities --- Sri Lankan algae --- anticancer --- sulfated polysaccharide --- Celluclast --- sargassum --- antioxidant --- Maldives --- Padina boryana --- zebrafish --- apoptosis --- DR4 --- mitochondrial pathway --- cancer --- metastasis --- epithelial mesenchymal transition --- nanoparticles --- Helicobacter pylori --- mozuku --- Cladosiphon okamuranus Tokida --- urinalysis --- fucose --- enzymatic purification --- age-related macular degeneration --- VEGF --- oxidative stress --- Laminaria digitata --- Fucus distichus subsp. evanescens --- Saccharina latissima --- retinal pigment epithelium --- ROS --- Phaeophyta --- carbohydrate --- UVB irradiation --- HaCaT cells --- sulfated heterosaccharide --- dopamine neurons apoptosis --- PI3K–Akt --- ascorbic acid --- anti-lung cancer --- human lung carcinoma A-549 cells --- hydrogen peroxide --- Sargassum crassifolium --- fucoidan from Ascophyllum nodosum --- postprandial hyperglycemia --- in vitro and in vivo evaluation --- SGLT1 --- chitosan --- fibroblast growth factor-2 --- polyelectrolyte multilayer --- infrared spectroscopy --- quartz crystal microbalance --- sulfated polysaccharides --- natural defenses --- phenolic metabolism --- phenylalanine ammonia-lyase --- n/a --- PI3K-Akt

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Fucoidans are a group of fucose-containing sulfated polysaccharides found in many species of brown seaweeds, with numerous bioactive properties. As a highly bioactive seaweed substance with many promising physiological activities, fucoidans have attracted attention from many industries all over the world. Even though fucoidans are a rich source of bioactive properties, the structural properties and bioactive mechanisms of fucoidans are poorly understood. Therefore, novel studies that either characterize the physical properties or biological activities of fucoidans will fill the knowledge gap between industrial applications and the scientific background of those applications. Both purified and partially purified fucoidans isolated from brown seaweeds present high potential as preventative and therapeutic agents against number of chronic diseases, due to their anti-inflammatory, antioxidant, anticancer, neuroprotective, antiviral, antimicrobial, and anticoagulative properties. This Special Issue is aimed at presenting updated information on well-documented studies of the structural characterization and major biological actions relevant for medical, cosmeceutical, and pharmaceutical applications that fucoidans isolated from brown seaweed can offer.

Medicine --- fucoidan --- low-molecular-weight fucoidan --- adriamycin --- nephrotic syndrome --- psoriasis --- Traf3ip2 --- microbiota --- mucin --- IgA --- fucoidans --- extraction --- brown algae --- production --- bioactivities --- Sri Lankan algae --- anticancer --- sulfated polysaccharide --- Celluclast --- sargassum --- antioxidant --- Maldives --- Padina boryana --- zebrafish --- apoptosis --- DR4 --- mitochondrial pathway --- cancer --- metastasis --- epithelial mesenchymal transition --- nanoparticles --- Helicobacter pylori --- mozuku --- Cladosiphon okamuranus Tokida --- urinalysis --- fucose --- enzymatic purification --- age-related macular degeneration --- VEGF --- oxidative stress --- Laminaria digitata --- Fucus distichus subsp. evanescens --- Saccharina latissima --- retinal pigment epithelium --- ROS --- Phaeophyta --- carbohydrate --- UVB irradiation --- HaCaT cells --- sulfated heterosaccharide --- dopamine neurons apoptosis --- PI3K-Akt --- ascorbic acid --- anti-lung cancer --- human lung carcinoma A-549 cells --- hydrogen peroxide --- Sargassum crassifolium --- fucoidan from Ascophyllum nodosum --- postprandial hyperglycemia --- in vitro and in vivo evaluation --- SGLT1 --- chitosan --- fibroblast growth factor-2 --- polyelectrolyte multilayer --- infrared spectroscopy --- quartz crystal microbalance --- sulfated polysaccharides --- natural defenses --- phenolic metabolism --- phenylalanine ammonia-lyase --- fucoidan --- low-molecular-weight fucoidan --- adriamycin --- nephrotic syndrome --- psoriasis --- Traf3ip2 --- microbiota --- mucin --- IgA --- fucoidans --- extraction --- brown algae --- production --- bioactivities --- Sri Lankan algae --- anticancer --- sulfated polysaccharide --- Celluclast --- sargassum --- antioxidant --- Maldives --- Padina boryana --- zebrafish --- apoptosis --- DR4 --- mitochondrial pathway --- cancer --- metastasis --- epithelial mesenchymal transition --- nanoparticles --- Helicobacter pylori --- mozuku --- Cladosiphon okamuranus Tokida --- urinalysis --- fucose --- enzymatic purification --- age-related macular degeneration --- VEGF --- oxidative stress --- Laminaria digitata --- Fucus distichus subsp. evanescens --- Saccharina latissima --- retinal pigment epithelium --- ROS --- Phaeophyta --- carbohydrate --- UVB irradiation --- HaCaT cells --- sulfated heterosaccharide --- dopamine neurons apoptosis --- PI3K-Akt --- ascorbic acid --- anti-lung cancer --- human lung carcinoma A-549 cells --- hydrogen peroxide --- Sargassum crassifolium --- fucoidan from Ascophyllum nodosum --- postprandial hyperglycemia --- in vitro and in vivo evaluation --- SGLT1 --- chitosan --- fibroblast growth factor-2 --- polyelectrolyte multilayer --- infrared spectroscopy --- quartz crystal microbalance --- sulfated polysaccharides --- natural defenses --- phenolic metabolism --- phenylalanine ammonia-lyase