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Book
Severe Eosinophilic Disorders: Mechanisms and Clinical Management
Authors: --- ---
Year: 2019 Publisher: Frontiers Media SA

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Abstract

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact


Book
Neutrophil Communication
Authors: --- --- ---
Year: 2020 Publisher: Frontiers Media SA

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact


Book
Neutrophil Communication
Authors: --- --- ---
Year: 2020 Publisher: Frontiers Media SA

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Abstract

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact


Book
Severe Eosinophilic Disorders: Mechanisms and Clinical Management
Authors: --- ---
Year: 2019 Publisher: Frontiers Media SA

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Abstract

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact


Book
NETosis 2: The Excitement Continues
Authors: --- ---
Year: 2017 Publisher: Frontiers Media SA

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Abstract

NETosis, a form of cell death that manifests by the release of decondensed chromatin to the extracellular space, provides valuable insights into mechanisms and consequences of cellular demise. Because extracellular chromatin can immobilize microbes, the extended nucleohistone network was called a neutrophil extracellular trap (NET), and the process of chromatin release was proposed to serve an innate immune defense function. Extracellular chromatin NETs were initially observed in studies of neutrophils and are most prominent in these types of granulocytes. Subsequent studies showed that other granulocytes and, in a limited way, other cells of the innate immune response may also release nuclear chromatin following certain kinds of stimulation. Variations of NETosis were noted with cells that remain temporarily motile after the release of chromatin. Numerous stimuli for NETosis were discovered, including bacterial breakdown products, inflammatory stimuli, particulate matter, certain crystals, immune complexes and activated thrombocytes. Fundamental explorations into the mechanisms of NETosis observed that neutrophil enzyme activity (PAD4, neutrophil elastase, proteinase 3 and myeloperoxidase) and signal transduction pathways contribute to the regulation of NETosis. Histones in NET chromatin become modified by peptidylarginine deiminase 4 (PAD4) and cleaved at specific sites by proteases, leading to extensive chromatin externalization. In addition, NETs serve for attachment of bactericidal enzymes including myeloperoxidase, leukocyte proteases, and the cathelicidin LL-37. NETs are decorated with proteases and may thus contribute to tissue destruction. However, the attachment of these enzymes to NET-associated supramolecular structures restricts systemic spread of the proteolytic activity. While the benefit of NETs in an infection appears obvious, NETs also participate as key protagonists in various pathologic states. Therefore, it is essential for NETs to be efficiently cleared; otherwise digestive enzymes may gain access to tissues where inflammation takes place. Persistent NET exposure at sites of inflammation may lead to a further complication: NET antigens may provoke acquired immune responses and, over time, could initiate autoimmune reactions, serve as antigen for nuclear autoantibodies and foster DNA immune complex-related inflammation. Neutrophil products and deiminated proteins comprise an important group of autoantigens in musculoskeletal disorders. Aberrant NET synthesis and/or clearance are often associated with inflammatory and autoimmune conditions. Recent evidence also implicates aberrant NET formation in the development of endothelial damage, atherosclerosis and thrombosis. Intravital microscopy provides evidence for conditions that induce NETosis in vivo. Furthermore, NETs can easily be detected in synovial fluid and tissue sections of patients with arthritis and gout. NETosis is thus of interest to researchers who investigate innate immune responses, host-pathogen interactions, chronic inflammatory disorders, cell and vascular biology, biochemistry, and autoimmunity. As we enter the second decade of research on NETosis, it is useful and timely to review the mechanisms and pathways of NET formation, their role in bacterial and fungal defense and their importance as inducers of autoimmune responses.


Book
Neutrophil Communication
Authors: --- --- ---
Year: 2020 Publisher: Frontiers Media SA

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Abstract

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact


Book
Severe Eosinophilic Disorders: Mechanisms and Clinical Management
Authors: --- ---
Year: 2019 Publisher: Frontiers Media SA

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Abstract

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact


Book
Neutrophil Extracellular Traps : Mechanisms and Role in Health and Disease
Authors: ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Neutrophils regulate immune responses during homeostasis as well as disease pathogenesis. Especially, the neutrophils extracellular traps largely contribute to necroinflammation. This book highlights the role of neutrophils and neutrophils extracellular traps in various sterile and non-sterile, acute and chronic inflammatory conditions affecting both human and animal health.


Book
Neutrophil Extracellular Traps : Mechanisms and Role in Health and Disease
Authors: ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Neutrophils regulate immune responses during homeostasis as well as disease pathogenesis. Especially, the neutrophils extracellular traps largely contribute to necroinflammation. This book highlights the role of neutrophils and neutrophils extracellular traps in various sterile and non-sterile, acute and chronic inflammatory conditions affecting both human and animal health.


Book
Neutrophil Extracellular Traps : Mechanisms and Role in Health and Disease
Authors: ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

Loading...
Export citation

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Bookmark

Abstract

Neutrophils regulate immune responses during homeostasis as well as disease pathogenesis. Especially, the neutrophils extracellular traps largely contribute to necroinflammation. This book highlights the role of neutrophils and neutrophils extracellular traps in various sterile and non-sterile, acute and chronic inflammatory conditions affecting both human and animal health.

Keywords

Medicine --- head-and-neck cancer --- metastasis --- neutrophils --- NETs --- NETosis --- innate immunity --- G-CSF --- neutrophils extracellular traps --- ophthalmology --- diseases --- neutrophil extracellular traps (NETs) --- Alzheimer's disease --- multiple sclerosis --- ischemic stroke --- meningitis --- central nervous system --- brain --- neurons --- brain-blood barrier --- equine recurrent uveitis --- horse --- cathelicidin --- neutrophil extracellular traps --- Candida albicans --- quorum sensing --- farnesol --- cerebrospinal fluid --- adults --- children --- infection --- chemokines --- cytokines --- borrelia --- virus --- hemozoin --- plasma --- fibrinogen --- platelet --- malaria --- NLRP3 inflammasome --- IL-1β --- cardiovascular disease --- inflammation --- diabetes --- obesity --- liver injury --- neutrophil extracellular trap --- myeloperoxidase --- carbon tetrachloride --- autoimmunity --- autoimmune diseases --- autoantigens --- SARS-CoV-2 --- coronavirus --- complement --- thrombosis --- MERS-CoV --- necroinflammation --- periodontitis --- neutrophil functions --- head-and-neck cancer --- metastasis --- neutrophils --- NETs --- NETosis --- innate immunity --- G-CSF --- neutrophils extracellular traps --- ophthalmology --- diseases --- neutrophil extracellular traps (NETs) --- Alzheimer's disease --- multiple sclerosis --- ischemic stroke --- meningitis --- central nervous system --- brain --- neurons --- brain-blood barrier --- equine recurrent uveitis --- horse --- cathelicidin --- neutrophil extracellular traps --- Candida albicans --- quorum sensing --- farnesol --- cerebrospinal fluid --- adults --- children --- infection --- chemokines --- cytokines --- borrelia --- virus --- hemozoin --- plasma --- fibrinogen --- platelet --- malaria --- NLRP3 inflammasome --- IL-1β --- cardiovascular disease --- inflammation --- diabetes --- obesity --- liver injury --- neutrophil extracellular trap --- myeloperoxidase --- carbon tetrachloride --- autoimmunity --- autoimmune diseases --- autoantigens --- SARS-CoV-2 --- coronavirus --- complement --- thrombosis --- MERS-CoV --- necroinflammation --- periodontitis --- neutrophil functions

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