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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Pharmacology --- epilepsy --- comorbidities --- experimental-animal models --- clinical epilepsy --- antiepileptics drugs

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Despite the difficulty in comparing clinic-based human tests with animal model testing, there is still great value in pursuing translational approaches, as tests and treatment strategies might be developed to improve brain function in humans suffering from neurological conditions and knowledge obtained from human behavioral studies can be used to further improve the animal models of behavioral analysis. In Animal Models of Behavioral Analysis, expert neuroscientists focus on approaches to translate and compare behavioral tests used in animals with those used in humans not only to increase our understanding of brain function across species but also to provide objective performance measures and bridge the gap between behavioral alterations in humans with cognitive disorders and the correlating animal models of these conditions. Written in the Neuromethods series format, the chapters provide authoritative reviews of many commonly used approaches in the field today. Provocative and cutting-edge, Animal Models of Behavioral Analysis seeks to aid researchers in further developing these vital techniques in an effort to advance studies in both the clinic and the laboratory.

Behavioral assessment. --- Animal models. --- Behavioral assessment --- Behavioral Sciences --- Research --- Investigative Techniques --- Psychology --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Science --- Behavioral Disciplines and Activities --- Behavioral Research --- Models, Animal --- Psychology, Comparative --- Natural Science Disciplines --- Psychiatry and Psychology --- Disciplines and Occupations --- Medicine --- Social Sciences --- Health & Biological Sciences --- Neurology --- Animal models --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Comparative Psychology --- Comparative Psychologies --- Psychologies, Comparative --- Experimental Animal Models --- Laboratory Animal Models --- Animal Model --- Animal Model, Experimental --- Animal Model, Laboratory --- Animal Models --- Animal Models, Experimental --- Animal Models, Laboratory --- Experimental Animal Model --- Laboratory Animal Model --- Model, Animal --- Model, Experimental Animal --- Model, Laboratory Animal --- Models, Experimental Animal --- Models, Laboratory Animal --- Research, Behavioral --- Sciences --- Factors, Psychological --- Psychological Factors --- Psychological Side Effects --- Psychologists --- Psychosocial Factors --- Side Effects, Psychological --- Factor, Psychological --- Factor, Psychosocial --- Factors, Psychosocial --- Psychological Factor --- Psychological Side Effect --- Psychologist --- Psychosocial Factor --- Side Effect, Psychological --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Laboratory Research --- Research Activities --- Research and Development --- Research Priorities --- Activities, Research --- Activity, Research --- Development and Research --- Priorities, Research --- Priority, Research --- Research Activity --- Research Priority --- Research, Laboratory --- Proxemics --- Behavioral Science --- Proxemic --- Science, Behavioral --- Sciences, Behavioral --- Assessment of behavior --- Behavior assessment --- Behavioral analysis --- Behavioral evaluation --- Neurosciences. --- Neurology. --- Laboratory animals. --- Animal Models. --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Nervous system --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Diseases

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Bone Regeneration --- Tissue Engineering --- Bone Transplantation --- Bone regeneration --- Tissue engineering. --- Bone-grafting --- Bones --- Os --- Génie tissulaire --- Cytology. --- Régénération --- Greffe --- Cytologie --- Bone Transplantation. --- Bone and Bones --- Models, Animal --- Research Design --- Experimental Animal Models --- Laboratory Animal Models --- Animal Model --- Animal Model, Experimental --- Animal Model, Laboratory --- Animal Models --- Animal Models, Experimental --- Animal Models, Laboratory --- Experimental Animal Model --- Laboratory Animal Model --- Model, Animal --- Model, Experimental Animal --- Model, Laboratory Animal --- Models, Experimental Animal --- Models, Laboratory Animal --- Animal Experimentation --- Data Adjustment --- Data Reporting --- Design, Experimental --- Designs, Experimental --- Error Sources --- Experimental Designs --- Matched Groups --- Methodology, Research --- Problem Formulation --- Research Methodology --- Research Proposal --- Research Strategy --- Research Technics --- Research Techniques --- Scoring Methods --- Experimental Design --- Adjustment, Data --- Adjustments, Data --- Data Adjustments --- Design, Research --- Designs, Research --- Error Source --- Formulation, Problem --- Formulations, Problem --- Group, Matched --- Groups, Matched --- Matched Group --- Method, Scoring --- Methods, Scoring --- Problem Formulations --- Proposal, Research --- Proposals, Research --- Reporting, Data --- Research Designs --- Research Proposals --- Research Strategies --- Research Technic --- Research Technique --- Scoring Method --- Source, Error --- Sources, Error --- Strategies, Research --- Strategy, Research --- Technic, Research --- Technics, Research --- Technique, Research --- Techniques, Research --- Research --- Clinical Trials Data Monitoring Committees --- cytology --- methods --- Bone Regeneration. --- Tissue Engineering.

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Cancer patients have benefitted greatly from recent advances in the drugs, dose regimens, and combinations used to treat their primary tumor and for the treatment or prevention of spread of their disease. Due to the advances in chemotherapy and other aspects of prevention, early detection, and treatment modalities, an increasing percentage of patients are surviving the disease. For some types of cancer, the majority of patients live decades beyond their diagnosis. For this they are forever thankful and appreciative of the drugs that helped lead to this increased survival rate. But no drug is devoid of adverse effects. This also applies to chemotherapeutic agents. The acute cytotoxic effects of these agents are well known––indeed are often required for their therapeutic benefit. The chronic adverse effects are varied and in some cases less well known. With the increase in survival rates, there has emerged a new awareness of these chronic adverse effects.

Antineoplastic agents --Side effects. --- Cancer --Chemotherapy --Complications. --- Cognition disorders. --- Neurotoxic agents. --- Cancer --- Cognition disorders --- Antineoplastic agents --- Neurotoxic agents --- Nervous System Diseases --- Kinetics --- Therapeutics --- Investigative Techniques --- Delirium, Dementia, Amnestic, Cognitive Disorders --- Poisoning --- Therapeutic Uses --- Mental Disorders --- Substance-Related Disorders --- Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Biochemical Phenomena --- Pharmacologic Actions --- Psychiatry and Psychology --- Chemical Actions and Uses --- Chemical Phenomena --- Chemicals and Drugs --- Phenomena and Processes --- Drug Therapy --- Pharmacokinetics --- Cognition Disorders --- Neurotoxicity Syndromes --- Antineoplastic Agents --- Models, Animal --- Medicine --- Health & Biological Sciences --- Oncology --- Chemotherapy --- Complications --- Side effects --- Complications. --- Side effects. --- Neuropoisons --- Neurotoxicants --- Neurotoxins --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Cognitive disorders --- Complications and sequelae --- Medicine. --- Cancer research. --- Biomedicine. --- Biomedicine general. --- Cancer Research. --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Poisons --- Drugs --- Psychology, Pathological --- Oncology. --- Tumors --- Health Workforce --- Biomedicine, general. --- Neurotoxicity Syndromes. --- Drug-Related Side Effects and Adverse Reactions. --- Models, Animal. --- chemically induced. --- pharmacokinetics. --- toxicity. --- Animals, Model. --- Encephalopathy, Toxic --- Nervous System Poisoning --- Neurotoxic Disorders --- Neurotoxin Diseases --- Neurotoxin Disorders --- Toxic Encephalitis --- Poisoning, Nervous System --- Encephalitides, Toxic --- Encephalitis, Toxic --- Encephalopathies, Toxic --- Nervous System Poisonings --- Neurotoxic Disorder --- Neurotoxicity Syndrome --- Neurotoxin Disease --- Neurotoxin Disorder --- Poisonings, Nervous System --- Syndrome, Neurotoxicity --- Syndromes, Neurotoxicity --- Toxic Encephalitides --- Toxic Encephalopathies --- Toxic Encephalopathy --- Adverse Drug Event --- Adverse Drug Reaction --- Drug Side Effects --- Drug Toxicity --- Side Effects of Drugs --- Toxicity, Drug --- Adverse Drug Events --- Adverse Drug Reactions --- Drug Event, Adverse --- Drug Events, Adverse --- Drug Reaction, Adverse --- Drug Reactions, Adverse --- Drug Related Side Effects and Adverse Reactions --- Drug Side Effect --- Drug Toxicities --- Effects, Drug Side --- Reactions, Adverse Drug --- Side Effect, Drug --- Side Effects, Drug --- Toxicities, Drug --- Pharmaceutical Preparations --- Contraindications, Drug --- Drug Interactions --- Clinical Trials, Phase IV as Topic --- adverse effects --- toxicity --- Experimental Animal Models --- Laboratory Animal Models --- Animal Model --- Animal Model, Experimental --- Animal Model, Laboratory --- Animal Models --- Animal Models, Experimental --- Animal Models, Laboratory --- Experimental Animal Model --- Laboratory Animal Model --- Model, Animal --- Model, Experimental Animal --- Model, Laboratory Animal --- Models, Experimental Animal --- Models, Laboratory Animal --- Animal Experimentation

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Immune System Diseases --- Immune diseases --- Immune disorders --- Immunité [Maladies de l' ] --- Immunité [Troubles de l' ] --- Immunologic diseases --- Immunologic disorders --- Immunological diseases --- Immunologische ziekten --- Maladies immunitaires --- Maladies immunologiques --- Retroviruses --- Retrovirussen --- Rétrovirus --- Système immunitaire--Maladies --- RETROVIRIDAE --- Retroviridae Infections --- ACQUIRED IMMUNODEFICIENCY SYNDROME --- DISEASE MODELS, ANIMAL --- Immunologic Deficiency Syndromes --- Neoplasms --- veterinary --- Acquired Immunodeficiency Syndrome --- Retrovirus infections --- DISEASE MODELS --- IMMUNOLOGIC DEFICIENCY SYNDROMES --- NEOPLASMS --- Retroviridae --- RETROVIRUS INFECTIONS --- animals --- Acquired Immunodeficiency Syndrome. --- Retrovirus infections. --- Retroviridae. --- animals. --- veterinary. --- Acquired immunodeficiency syndrome. --- Disease models --- Immunologic deficiency syndromes --- Animals. --- Veterinary. --- Animals --- Diseases --- RNA Virus Infections --- RNA Viruses --- Oncogenic Viruses --- Models, Biological --- Animal Diseases --- Models, Animal --- Viruses --- Investigative Techniques --- Vertebrate Viruses --- Virus Diseases --- Models, Theoretical --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Organisms --- Disease Models, Animal --- Biological Model --- Biological Models --- Model, Biological --- Models, Biologic --- Biologic Model --- Biologic Models --- Model, Biologic --- Tumor Viruses --- Oncogenic Virus --- Tumor Virus --- Virus, Oncogenic --- Virus, Tumor --- Viruses, Oncogenic --- Viruses, Tumor --- Carcinogens --- RNA Rodent Viruses --- RNA Rodent Virus --- RNA Virus --- Rodent Virus, RNA --- Rodent Viruses, RNA --- Virus, RNA --- Virus, RNA Rodent --- Viruses, RNA --- Viruses, RNA Rodent --- Infections, RNA Virus --- Infection, RNA Virus --- RNA Virus Infection --- Virus Infection, RNA --- Virus Infections, RNA --- Diseases, Animal --- Disease --- Veterinary Medicine --- Deficiency Syndrome, Immunologic --- Deficiency Syndromes, Antibody --- Deficiency Syndromes, Immunologic --- Immunologic Deficiency Syndrome --- Immunological Deficiency Syndromes --- Antibody Deficiency Syndrome --- Antibody Deficiency Syndromes --- Deficiency Syndrome, Antibody --- Deficiency Syndrome, Immunological --- Deficiency Syndromes, Immunological --- Immunological Deficiency Syndrome --- Syndrome, Antibody Deficiency --- Syndrome, Immunologic Deficiency --- Syndrome, Immunological Deficiency --- Syndromes, Antibody Deficiency --- Syndromes, Immunologic Deficiency --- Syndromes, Immunological Deficiency --- Antibodies --- Infections, Retroviridae --- Infections, Retrovirus --- XMRV Infection --- Xenotropic MuLV-related Virus Infection --- Xenotropic Murine Leukemia Virus-related Virus Infection --- Retrovirus Infections --- Infection, Retroviridae --- Infection, Retrovirus --- Infection, XMRV --- Infections, XMRV --- Retroviridae Infection --- Retrovirus Infection --- XMRV Infections --- Xenotropic MuLV related Virus Infection --- Xenotropic Murine Leukemia Virus related Virus Infection --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Leukemogenic Viruses --- Leukoviruses --- Oncornaviruses --- Oncovirinae --- Oncoviruses --- Oncoviruses, Type C --- RNA Tumor Viruses --- Type C Oncoviruses --- C Oncovirus, Type --- C Oncoviruses, Type --- Leukemogenic Virus --- Leukovirus --- Oncornavirus --- Oncovirus --- Oncovirus, Type C --- RNA Tumor Virus --- Retrovirus --- Tumor Virus, RNA --- Tumor Viruses, RNA --- Type C Oncovirus --- Virus, Leukemogenic --- Virus, RNA Tumor --- Viruses, Leukemogenic --- Viruses, RNA Tumor --- Animal Disease Model --- Animal Disease Models --- Disease Model, Animal --- Animals, Laboratory --- Experimental Model --- Experimental Models --- Mathematical Model --- Model, Experimental --- Models (Theoretical) --- Models, Experimental --- Models, Theoretic --- Theoretical Study --- Mathematical Models --- Model (Theoretical) --- Model, Mathematical --- Model, Theoretical --- Models, Mathematical --- Studies, Theoretical --- Study, Theoretical --- Theoretical Model --- Theoretical Models --- Theoretical Studies --- Computer Simulation --- Systems Theory --- Viral Diseases --- Viral Infections --- Virus Infections --- Disease, Viral --- Disease, Virus --- Diseases, Viral --- Diseases, Virus --- Infection, Viral --- Infection, Virus --- Infections, Viral --- Infections, Virus --- Viral Disease --- Viral Infection --- Virus Disease --- Virus Infection --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Animal Viruses --- Zoophaginae --- Animal Virus --- Virus --- Virus, Animal --- Viruses, Animal --- Genetic Vectors --- Microbiology --- Diseases of Immune System --- Immune Diseases --- Immunological Diseases --- Immune Disorders --- Immune System Disorders --- Immunologic Diseases --- Disease, Immune --- Disease, Immune System --- Disease, Immunologic --- Disease, Immunological --- Disorder, Immune System --- Immune Disease --- Immune Disorder --- Immune System Disease --- Immune System Disorder --- Immunologic Disease --- Immunological Disease --- Experimental Animal Models --- Laboratory Animal Models --- Animal Model --- Animal Model, Experimental --- Animal Model, Laboratory --- Animal Models --- Animal Models, Experimental --- Animal Models, Laboratory --- Experimental Animal Model --- Laboratory Animal Model --- Model, Animal --- Model, Experimental Animal --- Model, Laboratory Animal --- Models, Experimental Animal --- Models, Laboratory Animal --- Animal Experimentation --- deficiency --- Disease Models, Animal. --- Retroviridae Infections - veterinary --- Immunologic Deficiency Syndromes - veterinary --- Neoplasms - veterinary