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Protozoology --- Eukaryota --- Eukaryotic cells --- Protozoologie --- Cellules eucaryotes --- Protozoaires --- Eukaryotic cells. --- Protozoology. --- Eukaryotic Cells. --- Eucaryotic cells --- Cell, Eukaryotic --- Cells, Eukaryotic --- Eukaryotic Cell --- Eukaryotic Cells --- Cells --- Protista --- Microbiology --- Protozoa --- Zoology --- Cellules eucaryotes. --- Protozoans --- Protozoons --- Invertebrates --- Protozoa.

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The three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function. Increasing evidence indicates that nuclear pore complexes (NPCs), the large protein channels that connect the nucleus to the cytoplasm, play a critical role in the establishment and maintenance of chromatin organization and in the regulation of gene activity. These findings, which oppose the traditional view of NPCs as channels with only one: the facilitation of nucleocytoplasmic molecule exchange, have completely transformed our understanding of these structures. This book describes our current knowledge of the role of NPCs in genome organization and gene expression regulation. It starts by providing an overview of the different compartments and structures of the nucleus and how they contribute to organizing the genome, then moves to examine the direct roles of NPCs and their components in gene expression regulation in different organisms, and ends by describing the function of nuclear pores in the infection and genome integration of HIV, in DNA repair and telomere maintenance, and in the regulation of chromosome segregation and mitosis. This book provides an intellectual backdrop for anyone interested in understanding how the gatekeepers of the nucleus contribute to safeguarding the integrity and function of the eukaryotic genome. .

Cell nuclei. --- Eukaryotic cells --- Genetics. --- Medicine. --- Gene expression. --- Medical genetics. --- Cell biology. --- Biomedicine. --- Gene Function. --- Gene Expression. --- Cell Biology. --- Eukaryotic cell genetics --- Cytogenetics --- Cell nucleus --- Nucleus (Cells) --- Cell organelles --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Genes --- Genetic regulation --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Expression --- Genetic aspects

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Biologie --- Biology --- Biology. --- Molecules to cells --- Molecular biology and heredity --- Evolution --- Microorganisms and fungi --- Plants --- Animals --- Behavior and ecology --- Darwin --- Molecules of life --- Cell structure --- Cell transport --- Cell energetics --- Photosynthesis --- Cell respiration --- Eukaryotic cell reproduction --- Mendelian genetics --- DNA --- Genes --- Microevolution --- Macroevolution --- Evolution and diversity --- Reproduction --- Growth and structure --- Transport mechanisms --- Regulation and response --- Invertebrates --- Chordates --- Neural control --- Thermoregulation, osmoregulation and excretion --- Hormonal control --- Digestion and nutrition --- Circulation --- Respiration --- Immune system --- Development --- Biosphere and biomes --- Ecosystems and communities --- Population dynamics --- Human impact --- Microorganisms and fungi. --- Cell respiration. --- Genes. --- Macroevolution. --- Regulation and response. --- Development. --- Human impact.

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Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells.  The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur.  Errors in DNA replication can lead to genome instability and cancer.  The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process.  A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings.  The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity.  This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA.   It is the cellular protein machinery that enables replication initiation to be activated and regulated.  We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.

Pathology --- Genetics --- Medicine --- Biology --- Health & Biological Sciences --- Eukaryotic cells --- Genetics. --- Eukaryotic cell genetics --- Cytogenetics --- Human genetics. --- Biological models. --- Microbial genetics. --- Microbial genomics. --- Human Genetics. --- Systems Biology. --- Microbial Genetics and Genomics. --- Heredity, Human --- Human biology --- Physical anthropology --- Models, Biological --- Genomics --- Microbial genetics --- Microorganisms --- Microbiology --- Systems biology. --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- Eukaryotic cells. --- Cytology. --- DNA replication. --- Molecular biology. --- DNA Replication --- Eukaryotic Cells --- Cell Biology --- Molecular Biology --- physiology --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Genetic Phenomena --- Cellular Biology --- Biologies, Cell --- Biologies, Cellular --- Biology, Cell --- Biology, Cellular --- Cell Biologies --- Cellular Biologies --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Chromosomal DNA replication --- DNA --- Replication of DNA --- Cell biology --- Cellular biology --- Cells --- Eucaryotic cells --- Protista --- Replication --- Synthesis

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Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, and RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a major contributor to gene expression. Continuing identification of the protein factors and cofactors and mRNA instability elements responsible for mRNA decay allow researchers to build a comprehensive picture of the highly orchestrated processes involved in mRNA decay and its regulation.