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Human biochemistry --- Pharmacology. Therapy --- Allergy --- Histamine --- Metabolism --- Physiological effect --- Toxicology --- Biogenic amines --- Ethylamines --- Imidazoles --- Inflammation --- Antihistamines --- Mediators

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Since its identification by Sir Henry H. Dale a century ago, histamine has become one of the most important multifunctional biogenic amines in the field of biomedicine. The pharmacological effects of histamine are mediated through four types of membrane histamine receptors; H1R, H2R, H3R and H4R, which are all heptahelical G-protein-coupled receptors. It has been known to play the broadest spectrum of activities in various physiological and pathological conditions including cell proliferation, differentiation, hematopoiesis, embryonic development, regeneration, wound healing, aminergic neurotransmission and numerous brain functions, secretion of pituitary hormones, regulation of gastrointestinal and circulatory functions, cardiovascular system, as well as inflammatory reactions, modulation of the immune response, endocrine function and homeostasis, and other important areas. This book is a compendium of the current state of established and investigational literature on Histamine, its receptors and their Agonists and antagonists. It provides a comprehensive overview of histamine biology in the field of biochemistry, cell biology, molecular biology, immunology, allergy, neurobiology, pharmacology, microbiology and reproductive biology. The first section on Histamine biology and physiology leads into subsequent sections on enzymology, pharmacology, regulation of the immune system and cell proliferation and role in allergic and other diseases including acid peptic diseases, inflammatory diseases, autoimmune and cancer diseases, nervous system, reproductive functions and hematopoiesis. The compilation of chapters in the book presents the most recent advances in histamine research and bridges the basic and clinical aspects of histamine biology.

Histamine -- Congresses. --- Histamine -- Effect of. --- Histamine. --- Histamine --- Immunology --- Immunology. --- Medicine. --- Biomedicine. --- Biomedicine general. --- Biogenic amines --- Ethylamines --- Imidazoles --- Inflammation --- Antihistamines --- Mediators --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biomedicine, general. --- Health Workforce

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This book provides a comprehensive overview on current histamine and histamine receptor research in context of human health and disease and reflect the multidisciplinary nature of the field. While the editors realize that it is almost impossible to cover the field completely within the constraints of a single HEP volume, nonetheless, all important aspects will be covered in one way or the other. An overarching introductory chapter will link the individual chapters and provide an overview on the field. This chapter will also link the book to the previous HEP volume on histamine receptors and the recent HEP volume on the pharmacology of itch. Great attention will be paid to complementation of existing literature while avoiding undue duplication. The book will cover new methods for analysis of histamine and histamine metabolites, development of methods for histamine receptor analysis, signal transduction, histamine release, regulation of immune cells by histamine, histamine metabolism and associated diseases, regulation of major organ systems by histamine and development of new drugs and experimental tools for the study of histamine receptors.

Medicine. --- Immunology. --- Neurosciences. --- Pharmacology. --- Endocrinology. --- Biochemistry. --- Biomedicine. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Histamine. --- Histamine --- Receptors. --- Histamine receptors --- Receptors, Histamine --- Cell receptors --- Chemoreceptors --- Biogenic amines --- Ethylamines --- Imidazoles --- Inflammation --- Antihistamines --- Mediators --- Toxicology. --- Internal medicine --- Hormones --- Immunobiology --- Life sciences --- Serology --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Composition --- Toxicology --- Endocrinology . --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the “father of tamoxifen” - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a “failed morning after contraceptive” to become the “gold standard” for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen’s pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.

Breast --- Tamoxifen --- Therapeutics --- Stilbenes --- Humanities --- Neoplasms by Site --- Antineoplastic Agents --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Neoplasms --- Therapeutic Uses --- Benzylidene Compounds --- Pharmacologic Actions --- Diseases --- Benzene Derivatives --- Hydrocarbons, Aromatic --- Chemical Actions and Uses --- Chemicals and Drugs --- Hydrocarbons, Cyclic --- Hydrocarbons --- Organic Chemicals --- Antineoplastic Agents, Hormonal --- History --- Breast Neoplasms --- Drug Therapy --- Medicine --- Health & Biological Sciences --- Oncology --- Chemotherapy --- Cancer --- Tamoxifen. --- Chemoprevention. --- Chemotherapy. --- Medicine. --- Cancer research. --- Pharmacology. --- Endocrinology. --- Oncology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Antineoplastic agents --- Benzene --- Ethylamines --- Selective estrogen receptor modulators --- Oncology  . --- Toxicology. --- Internal medicine --- Hormones --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology --- Endocrinology . --- Drug effects --- Medical pharmacology --- Medical sciences --- Drugs --- Pharmacy --- Cancer research --- Physiological effect

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Finally - a book that covers all aspects of the illicit use of cocaine, amphetamines, ecstasy and/or designer drugs such as GHB, written by two experts in their field. The use of these drugs remains a continuous threat in health and medical care delivery, and this book will be an essential asset to the physician who may have to face the evaluation of patients whose use of these drugs compromises an effective treatment plan for other health issues. The book has been conceived to fill the void in existing physician reference materials, and provides a comprehensive review of the theoretical knowledge and scope of pharmacotherapy in individuals who are hooked on a psychoactive substance. While detailed scientific information is obtainable in other major articles, the book's straightforward format and style, along with its illustrations, will make for easy reading as emphasis is put on information specifically related to drugs that occur most abused in today’s society. The information provided is based on clinical practice rather than pure experimental data, which will give the physician more effective tools useful in their daily practice. Many mechanisms of action of abuse are described in detail and references are provided to direct the reader to further sources for additional information. As a special feature, the book incorporates uncluttered tables and charts, which result in immediate clarification of the mode of action on the central nervous system and the reason for misuse, thus avoiding usual long and fatiguing text in common reference books. The book aims to give the reader a clear and concise plan on what to do when being faced with an overdose situation. A well-organized Table of Contents rapidly leads the reader from general pharmacological issues to the specific overdose syndrome and its management. Additionally, significant emphasis is placed on the practical do's and don’ts for physicians, with special reference to the predictive signs of aberrant drug-related behavior and the identification of the drug diverter by using urine drug screening.

Drug abusers -- Medical care. --- Drugs of abuse. --- Psychotropic drugs -- Physiological effect. --- Psychotropic drugs -- Side effects. --- Psychotropic drugs. --- Psychotropic drugs --- Drugs of abuse --- Drug abusers --- Substance-Related Disorders --- Pharmacology --- Cocaine --- Amphetamine --- Designer Drugs --- N-Methyl-3,4-methylenedioxyamphetamine --- Tropanes --- Amphetamines --- Pharmaceutical Preparations --- Biological Science Disciplines --- Diseases --- Mental Disorders --- Azabicyclo Compounds --- Phenethylamines --- Psychiatry and Psychology --- Heterocyclic Compounds, Bridged-Ring --- Alkaloids --- Chemicals and Drugs --- Natural Science Disciplines --- Aza Compounds --- Bicyclo Compounds, Heterocyclic --- Heterocyclic Compounds --- Disciplines and Occupations --- Ethylamines --- Amines --- Organic Chemicals --- Bicyclo Compounds --- Bridged Compounds --- Polycyclic Compounds --- Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Physiological effect --- Side effects --- Medical care --- Drug abuse --- Physiological effect. --- Treatment. --- Medicine. --- Pharmacy. --- Pharmacology. --- Pharmaceutical technology. --- Emergency medicine. --- Biomedicine. --- Pharmacology/Toxicology. --- Biomedicine general. --- Pharmaceutical Sciences/Technology. --- Medicine/Public Health, general. --- Emergency Medicine. --- Toxicology. --- Medicine, Emergency --- Medicine --- Critical care medicine --- Disaster medicine --- Medical emergencies --- Chemistry --- Drugs --- Materia medica --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Chemicals --- Poisoning --- Poisons --- Toxicology --- Biomedicine, general. --- Health Workforce --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy