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Information on bioactive ether lipids and their involvement in neurological disorders is currently scattered throughout the literature in the form of original papers and reviews. Metabolism and Functions of Bioactive Ether Lipids in the Brain provides readers with a comprehensive description of metabolism of bioactive ether lipids in the brain, activities of enzymes involved in their metabolism, and their involvement in neurological disorders. This book will be particularly useful to neuroscience graduate students, academics, and researchers. Clinicians will find this book useful for understanding molecular aspects of neurodegeneration in acute neural trauma and neurodegenerative diseases that are mediated by plamalogen-selective phospholipases A2 and PAF acetyl hydrolases. This monograph is the first to provide a comprehensive description of not only metabolism and role of plasmalogen and platelet activating factor in brain tissue but also the involvement of these lipids with abnormal signal transduction processes in neurological disorders. Key Features • Provides the neuroscience community with extensive description of ether lipids-derived lipid mediators their roles and association with neurological disorders • Particular attention given to the description of keys enzymes associated with the generation of ether lipid-derived lipid mediators • Illustrated with chemical structures and line diagrams of signal transduction pathways • Discusses the future direction of research on ether lipid metabolism About the Authors Akhlaq A. Farooqui is a leader in the field of bioactive ether lipids, glutamate-mediated neurotoxicity, and brain phospholipases A2. In collaboration with late Dr. Lloyd A. Horrocks, he discovered a plasmalogen-selective phospholipase A2 in brain and showed its stimulation in kainate-mediated neurotoxicity and brain tissue from patients with Alzheimer disease. He has also found a decrease in plasmalogen levels in brain from Alzheimer’s disease patients. This decrease in plasmalogens is due to the stimulation of phospholipases A2. Akhlaq A. Farooqui has authored two monographs, Glycerophospholipids in Brain: Phospholipase A2 in Neurological Disorders (Springer, 2006) and Neurochemical Aspects of Excitotoxicity (Springer, 2007). Tahira Farooqui is an expert on glycerophospholipid and sphingolipid metabolism and neural plasticity. She has published extensively on molecular mechanism of neuroinflammation, interactions between glycerophospholipid and sphingolipid-derived lipid mediators, and neural plasticity in the brain.

Ether lipids --- Brain --- Neurochemistry. --- Metabolism. --- Diseases --- Molecular aspects. --- Cerebrum --- Mind --- Central nervous system --- Head --- Biochemistry --- Neurosciences --- Lipid ethers --- Ethers --- Lipids --- Neurosciences. --- Neurology. --- Biochemistry. --- Biochemistry, general. --- Medical Biochemistry. --- Medicine --- Nervous system --- Neuropsychiatry --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Neural sciences --- Neurological sciences --- Neuroscience --- Composition --- Neurology . --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Pathology

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In biofilms, microorganisms are able to communicate together and assemble by themselves, creating a consortium with different properties from the original free-floating microorganisms. In fact, biofilm cells bind strongly to a living or non-living surface, enclosed in a self-produced extracellular matrix that is composed of extracellular polymeric substances. One benefit of this lifestyle is the increased resistance or tolerance to antimicrobial agents (e.g., antibiotics). Hence, research on the development of alternative strategies to prevent and control biofilms is highly relevant for society in terms of human health, industry and the environment. Different approaches to prevent or control biofilms using antibiotic alternative strategies were submitted to this Special Issue.

antibacterial drug --- vitamin B12 --- antisense oligonucleotides --- nucleic acid mimics --- LNA --- 2′OMe --- biocidal particles --- functionalization --- benzalkonium chloride --- Escherichia coli --- antimicrobial activity --- antimicrobial resistance --- natural alkylglycerols --- ether lipids --- 1-O-alkyl-sn-glycerols --- antibiofilm activity --- quorum sensing inhibition --- stainless steel --- polypropylene --- organic matter --- microbial resistance --- peracetic acid --- biofilms --- prosthesis-related infections --- heat shock --- ciprofloxacin --- antibacterial agents --- E. coli biofilms --- food contact surfaces --- biocontrol --- bacteriophages --- aluminum nitride --- composite --- antibacterial --- mechanical --- thermal --- cellulose acetate --- CAPE --- Candida --- antifungal --- biofilm --- apoptosis --- urinary tract devices --- probiotics --- Lactobacillus plantarum --- Lactobacillus rhamnosus --- displacement --- oral biofilm --- dental implants --- titanium implants --- antimicrobial --- surface coating --- anti-fouling --- n/a --- 2'OMe

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Platelets playa fundamental, life-saving role in hemostasis and blood clotting at sites of vascular injury. Unwanted platelet activation and arterial thombus formation are, however, implicated in the onset of myocardial infarction, stroke, and other cardiovascular diseases. Acceptance that platelets play a major role in the pathogenesis of atherosclerosis including coronary heart disease has revolutionized the pharmacological treatment of cardiovascular diseases, and aspirin is now an essential antiplatelet drug and the golden standard for future developments. Yet the search for better and perhaps safer antiplatelet drugs is one of the most active areas of investigation in both basic and clinical research. Platelets, especially human platelets, have also emerged as one of the major models for the study of inter- and intracellular signal transduction pathways. Many biochemists, cell biologists, pharmacologists, pathologists, hematologists, and cardiologists find platelets useful for studying processes such as adhesion, inside-out and outside-in signalling through the plasma membrane, channels, calcium homeostasis, protein kinases, the network of intracellular signal transduction cascades, and the release of vasoactive substances. The aim of the editors has been to compile chapters summarizing the current state-of-the-art information on the biochemistry, cell biology, pharmacology, and physiologic and pathophysiologic roles of human platelets. We hope that this volume represents the major aspects of current platelet research although it is perhaps inevitable that certain areas are covered less thoroughly than others. We would like to acknowledge the excellent help and support of the Springer-Verlag staff, in particular that of Ms. Doris Walker.

AGECP --- Acetyl glyceryl ether phosphorylcholine --- Affections plaquettaires --- Affections thrombocytaires --- Bloedplaatjes --- Bloedplaatjes--Activeringsfactor --- Bloedplaatjes--Stoornissen --- Blood platelet disorders --- Blood platelets --- Cellular information transduction --- Cellular signal transduction --- Celsignaal-transductie --- Facteur plaquettaire d'activation --- Factor [Plaatjes] activering --- Information transduction [Cellular ] --- PAF-acether --- Plaatjes [Bloed] --- Plaatjesfactor activatie --- Plaquettes sanguines --- Plaquettes sanguines--Troubles --- Platelet activating factor --- Platelets --- Signal transduction [Cellular ] --- Stoornissen van de bloedplaatjes --- Thrombocytes --- Thrombocytopathie --- Thrombocytopathy --- Thrombopathie --- Transduction du signal cellulaire --- Trombocyten --- Troubles des plaquettes sanguines --- Blood platelet disorders. --- Blood platelets. --- Cellular signal transduction. --- Platelet activating factor. --- Blood Platelets. --- Receptors. --- Receptors --- Pharmacology. --- Biochemistry. --- Human physiology. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Human Physiology. --- Human biology --- Medical sciences --- Physiology --- Human body --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Composition --- Physiological effect --- Blood --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Choline --- Ether lipids --- Inflammation --- Phospholipids --- Blood platelet receptors --- Platelet membrane receptors --- Platelet receptors --- Cell receptors --- Blood cells --- Megakaryocytes --- Diseases --- Mediators --- Activation