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Cancer-leading proteases : structures, functions, and inhibition
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ISBN: 0128181699 0128181680 9780128181690 9780128181683 Year: 2020 Publisher: London, England : Academic Press,

Proteolysis and physiological regulation
Authors: ---
ISBN: 0125882505 Year: 1976 Publisher: New York (N.Y.): Academic press


Book
Proteolytic enzymes : a pratical approach
Authors: ---
ISBN: 0199630585 0199630593 9780199630592 9780199630585 Year: 1989 Publisher: Oxford [etc.] : IRL Press,

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Abstract

This book offers comprehensive, unified coverage of proteolytic enzymes, which are useful in a multitude of important physiological processes. The emphasis here is on the practical aspects of the handling, characterization, inhibition, and use of these enzymes. The book provides general advice as well as specific examples. Written in a clear, readable style, the volume is an excellent resource for scientists who study proteases, or those who use them as probes for experimental and therapeutic purposes.


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Heparanase : From Basic Research to Clinical Applications
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ISBN: 3030345211 3030345203 Year: 2020 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.

Keywords

Cancer research. --- Oncology  . --- Molecular biology. --- Cancer Research. --- Oncology. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Tumors --- Cancer research --- Proteolytic enzymes --- Peptide hydrolases --- Proteases --- Hydrolases --- Physiological effect. --- Peptide Hydrolases --- Neoplasms. --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Esteroproteases --- Peptidases --- Proteinases --- Proteolytic Enzymes --- Gene Products, pol --- Enzims --- Cèl·lules --- Càncer --- Carcinoma --- Carcinosi --- Càncer d'ossos --- Càncer de cap --- Càncer de coll --- Càncer de bufeta --- Càncer de fetge --- Càncer de laringe --- Càncer de mama --- Càncer de pàncrees --- Càncer de pell --- Càncer de pròstata --- Càncer de pulmó --- Càncer de ronyó --- Càncer de tiroide --- Càncer d'ovari --- Càncer gastrointestinal --- Càncer ginecològic --- Càncer en els adolescents --- Càncer en els infants --- Medicaments antineoplàstics --- Melanoma --- Leucèmia --- Sarcoma --- Carcinògens --- Cèl·lules canceroses --- Cirurgia oncològica --- Infermeria oncològica --- Malalts de càncer --- Metàstasi --- Oncologia --- Biologia --- Fisiologia --- Reproducció --- Astròcits --- Blastoderma --- Cèl·lules eucariotes --- Cèl·lules epitelials --- Cèl·lules germinals --- Cèl·lules hepàtiques --- Cèl·lules i teixits vegetals --- Cèl·lules mare --- Cèl·lules musculars --- Cèl·lules sanguínies --- Citoplasma --- Cromatina --- Fecundació --- Fibroblasts --- Histologia --- Irritabilitat --- Mort cel·lular --- Neurones --- Neurones motores --- Patologia cel·lular --- Protoplasts --- Protozous --- Ou (Biologia) --- Ultraestructura (Biologia) --- Citologia --- Clonatge --- Embriologia --- Protoplasma --- Regeneració (Biologia) --- Biocatalitzadors --- Ferments --- Catalitzadors --- Proteïnes --- Coenzims --- Enzims al·lostèrics --- Enzims microbians --- Fibrinolítics --- Hidrolases --- Iduronat-2-sulfatasa --- Inducció enzimàtica --- Isoenzims --- Malt --- Metal·loenzims --- Oxidoreductases --- Transferases --- Biocatàlisi --- Fermentació

Hyperthermophilic enzymes : part A
Authors: ---
ISSN: 00766879 ISBN: 0121822354 012182232X 0121822311 9786611011154 1281011150 0080496865 9786611011147 1281011142 0080496857 9780121822323 9780121822316 9780121822354 Year: 2001 Volume: 330-331-334 Publisher: New York, NY ; London : Academic Press,

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Abstract

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymologyis one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.This volume and its companions (Volumes 31 and 334) cover all current knowledge concerni

Keywords

Proteolytic enzymes. --- DNA --- Enzyme Stability --- Enzymes --- Pyrococcus furiosus --- Pyrococcus --- Enzymes and Coenzymes --- Technology, Pharmaceutical --- Protein Stability --- Nucleic Acids --- Nucleic Acids, Nucleotides, and Nucleosides --- Thermococcaceae --- Biochemical Phenomena --- Chemicals and Drugs --- Investigative Techniques --- Chemical Phenomena --- Thermococcales --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Phenomena and Processes --- Euryarchaeota --- Archaea --- Organisms --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Temperature --- Hydrolases --- Weather --- Atmosphere --- Thermodynamics --- Meteorological Concepts --- Physical Phenomena --- Ecological and Environmental Phenomena --- Environment --- Biological Phenomena --- Environment and Public Health --- Health Care --- Bacteria --- Hot Temperature --- Peptide Hydrolases --- Archaea. --- Biochemistry -- Periodicals. --- Biochemistry. --- Enzymes -- Periodicals. --- Enzymes. --- Microorganisms. --- Glycoside Hydrolases --- Adaptation, Physiological --- Physiological Processes --- Adaptation, Biological --- Physiological Phenomena --- Biological Processes --- Microorganisms --- Effect of heat on. --- Effect of temperature on. --- Esteroproteases --- Peptidases --- Proteases --- Proteinases --- Proteolytic Enzymes --- Heat --- Hot Temperatures --- Temperature, Hot --- Temperatures, Hot --- Eubacteria --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Biologic Phenomena --- Biological Phenomenon --- Biological Process --- Phenomena, Biological --- Phenomena, Biologic --- Phenomenon, Biological --- Process, Biological --- Processes, Biological --- Environmental Impact --- Environmental Impacts --- Impact, Environmental --- Impacts, Environmental --- Environments --- Meteorologic Factors --- Meteorological Factors --- Concept, Meteorological --- Concepts, Meteorological --- Factor, Meteorologic --- Factor, Meteorological --- Factors, Meteorologic --- Factors, Meteorological --- Meteorologic Factor --- Meteorological Concept --- Meteorological Factor --- Biocatalysts --- Thermodynamic --- Ecological and Environmental Concepts --- Ecological and Environmental Processes --- Atmospheres --- Fog --- Fogs --- Temperatures --- Physical Phenomenon --- Physical Process --- Physical Concepts --- Physical Processes --- Concept, Physical --- Concepts, Physical --- Phenomena, Physical --- Phenomenon, Physical --- Physical Concept --- Process, Physical --- Processes, Physical --- Coenzymes and Enzymes --- Peptide hydrolases --- Micro-organisms, Effect of temperature on --- Ferments --- Soluble ferments --- Catalysts --- Proteins --- Enzymology --- Physiological effect --- ARCHAEA --- HEAT --- ENZYMES --- BIOLOGICAL EFFECTS --- Dna nucleotidyltransferases --- Isomerases --- Oxidoreductases --- Temperature effects (biological)

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