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This book focuses on the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes. It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. Mucosal Delivery of Drugs and Biologics in Nanoparticles emphasize the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs. It acknowledges the concerns around the potential toxicity of nanoparticles to the host; few chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host’s immune cells is discussed. Moreover, it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book will be the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.

Pharmaceutical technology. --- Pharmaceutical Sciences/Technology. --- Drug delivery systems. --- Drug delivery devices. --- Nanoparticles. --- Inhalers. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Atomizers --- Drug delivery devices --- Respiratory therapy --- Nanostructured materials --- Particles --- Devices, Drug delivery --- Drug delivery systems --- Medical instruments and apparatus --- Delivery systems, Drug --- Drug administration technology --- Drug delivery technology --- Drugs --- Pharmaceutical technology --- Equipment and supplies --- Delivery systems --- Nano-particles --- NPs (Nanoparticles) --- Nanoscale particles --- Tecnologia farmacèutica --- Membrana mucosa --- Mucosa --- Mucoses --- Túnica mucosa --- Epiteli --- Membranes (Biologia) --- Endometri --- Mucosa gastrointestinal --- Mucosa oral --- Farmàcia galènica --- Tècnica farmacèutica --- Tècniques farmacèutiques --- Tecnologies farmacèutiques --- Anàlisi de medicaments --- Biotecnologia farmacèutica --- Dispositius d'administració de medicaments --- Síntesi de fàrmacs --- Sistemes d'alliberament de medicaments --- Farmàcia

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This book presents cutting-edge papers and perspectives on the transport of oxygen to tissues by scientists in a multitude of disciplines such as biochemistry, engineering, mathematics, medicine, physics, physiology, veterinary and complementary medicine. The book is composed of the following 6 parts: Brain Oxygenation and Function, Tumor Oxygenation and Metabolism, Muscle Oxygenation and Sports Medicine, Cell Metabolism and Tissue Oxygenation, Methodology of O2 Measurements, and Special Topics. The articles in this book have been presented at the 42nd annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT 2019) held in Albuquerque, New Mexico, USA, from July 28 to July 31, 2019. Academics, clinical and industry researchers, engineers, as well as graduate students who are interested in oxygen transport to tissue will find this book a great reference and a useful learning resource. The chapters "Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury", "Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism" and "Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers" are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Medicine. --- Biomedicine, general. --- Health Workforce --- Oxygen --- Tissue respiration --- Physiological transport --- Physiological transport. --- Delivery of oxygen (Physiology) --- Oxygen delivery (Physiology) --- Oxygen transport (Physiology) --- Chalcogens --- Nonmetals --- Photosynthetic oxygen evolution --- Oxigen en l'organisme --- Teixits (Histologia) --- Fisiologia humana --- Biologia humana --- Ciències de la salut --- Fisiologia --- Mecànica humana --- Reproducció humana --- Cos humà --- Teixits (Biologia) --- Teixits animals --- Teixits humans --- Teixits orgànics --- Cèl·lules i teixits vegetals --- Cultiu de teixits --- Epiteli --- Músculs --- Periodonci --- Teixit nerviós --- Teixit connectiu --- Cèl·lules animals --- Histologia --- Empelts de teixits --- Òrgans (Anatomia) --- Composició del cos humà --- Oximetria --- Anoxèmia --- Medicine --- Biology --- Biomedical Research. --- Research. --- Biological research --- Biomedical research --- Oxygen,

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This book provides guidance regarding the approach to common scenarios encountered in the frozen section laboratory while underscoring diagnostic pitfalls and providing the proper level of diagnostic information to ensure clear communication. Given the use of frozen section in molecular and research pathology, the text also serves as a guide for morphologic examination. Written by experts in the field, the book is organized according to organ system with additional chapters discussing the roles of digital pathology and molecular assays. Each chapter is extensively illustrated to highlight key points that facilitate interpretation and highlight areas for potential error. The goal of this book is to help trainees understand the need for mastery of this unique diagnostic tool, and to aid pathologists who cover frozen section convert practical information provided into diagnostic improvements. Frozen Section Pathology is a comprehensive and state-of-the-art review and serves as a valuable resource for the general surgical pathologist with frozen section responsibilities as well as surgeons who regularly utilize frozen section.

Pathology. --- Surgery. --- Oncology  . --- General Surgery. --- Oncology. --- Tumors --- Surgery, Primitive --- Medicine --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Frozen tissue sections. --- Frozen histological sections --- Frozen sections (Histology) --- Histological sections, Frozen --- Tissue sections, Frozen --- Cryopreservation of organs, tissues, etc. --- Cryotomy --- Tissues --- Preservation --- Teixits (Histologia) --- Patologia --- Criogènia --- Criotècnica --- Enginyeria criogènica --- Enginyeria de les baixes temperatures --- Enginyeria del fred --- Tècnica criogènica --- Tecnologia de les baixes temperatures --- Enginyeria --- Temperatures baixes --- Materials a baixes temperatures --- Superconductivitat --- Patologia humana --- Medicina --- Bacteriologia --- Càlculs --- Degeneració (Patologia) --- Diagnòstic de laboratori --- Estenosi --- Etiologia --- Genètica mèdica --- Glucòlisi --- Hipertròfia --- Histopatologia --- Hèrnia --- Immunopatologia --- Inflamació --- Insuficiència sistèmica --- Malformacions --- Metàstasi --- Paleopatologia --- Patologia cel·lular --- Patologia veterinària --- Teratologia --- Xoc --- Anatomia patològica --- Diagnòstic --- Teixits (Biologia) --- Teixits animals --- Teixits humans --- Teixits orgànics --- Cèl·lules i teixits vegetals --- Cultiu de teixits --- Epiteli --- Músculs --- Periodonci --- Teixit nerviós --- Teixit connectiu --- Cèl·lules animals --- Histologia --- Empelts de teixits --- Òrgans (Anatomia)