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Antioxidative polyphenols represented by tannins and flavonoids are rich in numerous food sources and traditional natural medicines and currently attracting increased attention in health care and food industries because of their multiple biological activities that are favorable to human health. Commemorating the outstanding achievements on tannins by Dr. Takuo Okuda on the occasion of his passing away in December 2016, his colleagues, friends, and worldwide experts of polyphenol research have contributed 18 papers on their recent study to the Special Issue of Molecules. This book is its reprinted form. This covers reviews of structural features, historical usages, and biological activities of unique class of ellagitannins and condensed tannins, and original articles on the most up-to-date findings on the anticancer effect of green tea catechins, the antivirus effect of tannins comparing with the clinically used drugs, the analytical method of ellagitannins using quantitative NMR, the chemical structures of Hydrangea-blue complex (pigment) and condensed tannins in Ephedra sinica and purple prairie clover, and the relationship of condensed tannins in legumes and grape-marc with methane production in the in vitro ruminant system, and others. This book will be useful to natural product chemists and also to researchers in pharmaceutical and/or food industry.

Coreopsis lanceolata L. --- UV-Vis --- methanogenesis --- Lythraceae --- flavanone --- grape marc --- TDDFT --- Ephedra sinica --- macrocyclic oligomer --- triple-negative breast cancer --- antioxidant --- purple prairie clover --- chalcone --- neuraminidase --- fatty acid synthase --- (?)-epigallocatechin gallate --- epidermal growth factor --- NMR spectroscopy --- Aluminum ion --- Onagraceae --- Hydrangea macrophylla --- synthetic analogues --- blue color development --- amyloid-? peptide --- FTIR --- oseltamivir carboxylate --- quantitative NMR --- phloroglucinolysis --- thin layer chromatography --- European historic leathers --- FASN inhibition --- ECD --- colorimetric tests --- taxanes --- cynandione A --- conservation method --- 5-O-caffeoylquinic acid --- ellagitannin --- PC12 --- condensed tannin --- Trapa taiwanensis Nakai --- 1H-NMR --- Acacia --- (?)-epigallocatechin 3-gallate --- Geranium thunbergii --- condensed tannins --- immunomodulatory effect --- Acacia mearnsii bark --- Escherichia coli --- oligomer --- Horner–Wadsworth–Emmons reaction --- lung tumor --- Aspergillus fumigates --- in vitro batch fermentation --- metal complex --- Myrtaceae --- Cynanchum auriculatum --- molecular interactions --- phenolic glycoside --- bamboo leaf extract --- stability --- Microsporum canis --- Cynanchum wilfordii --- thiolysis --- anti-inflammation --- hydrolysable tannin --- geraniin --- NGF --- polyphenol --- revision --- ESI-mass --- bioactivity --- antifungal activities --- interferon-? --- antitumor effect --- tannin composition --- oenothein B --- zanamivir --- 2-O-?-laminaribiosyl-4-hydroxyacetophenone --- anticancer activity --- proanthocyanidin --- vegetable tanning --- Dittrichia viscosa --- differentiation --- aurone --- antioxidants --- protein precipitation --- apoptosis --- polyphenolic FASN inhibitors --- forage legume --- biological activities --- ultrahigh-resolution negative mode MALDI-TOF mass spectrometry --- overlay method --- spectroscopy --- wattle tannin --- immune checkpoint --- hormesis --- 3-O-glucosyldelphinidin --- gallotannin --- proanthocyanidins --- fatty acids --- flavonol --- inhibition --- structure --- Candida spp. --- Malassezia spp. --- ORAC assay --- neuroprotection --- crystal structure --- tannins

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This theme issue is to celebrate Professor Robert Verpoorte’s 75th birthday. Prof. Verpoorte has been working in Leiden University over 40 years. There is no need to dwell upon the contributions of Dr. Verpoorte to plant-derived natural products research during his whole life. Dr. Verpoorte was a highly productive scientist throughout his academic career, with over 800 scientific publications in the form of research papers, books, and book chapters. His research interests are very diverse, cover- ing numerous topics related to plant-based natural products such as plant cell biotech- nology, biosynthesis, metabolomics, genetic engineering, and green technology, as well as the isolation of new biologically active compounds. He has left indelible footprints in all these fields, and he is widely recognised as a pioneer in the work of the biosynthesis of indole alkaloids, NMR-based metabolomics, and green technology in natural products production. As close friends and colleagues who have been in nearly daily contact with him over the last 20 years viewing all of these remarkable scientific contributions, we felt compelled to recognize this by the publication of a Special Issue of this journal dedicated to him.Thus, this Special Issue has now finally been released with the help of many of his colleagues and former students as a token of our gratitude to his impressive work.The Special Issue covers five main natural products topics: (1) chemical profiling and metabolomics, (2) separation/isolation and identification of plant specialized metabolites, (3) pharmacognosy of natural products to identify bioactive molecules from natural prod- ucts, (4) novel formulation of natural products, and (5) overview of natural products as a source of bioactive molecules.

natural extract --- glycerin --- chemical profiling --- centrifugal partition chromatography --- 13C nuclear magnetic resonance --- cosmetic industry --- Psychotria malayana Jack --- type 2 diabetes --- α-glucosidase inhibitors --- LC-MS --- metabolomics --- molecular docking --- colorectal cancer --- HCT 116 --- telomerase --- telomerase inhibitor --- berberine --- downregulation --- cell cycle arrest --- telomere erosion --- molecular imaging --- direct analysis in real-time mass spectrometry --- ephedra alkaloids --- ephedrine --- methylephedrine --- Ephedra sinica --- natural products --- dereplication --- databases --- spectroscopy --- taxonomy --- molecular structures --- lignans --- secoisolariciresinol --- RNA interference --- flax --- osmotic stress --- 1H-NMR --- ionic liquids --- oxypeucedanin hydrate --- byakangelicin --- A. dahurica --- back-extraction --- enrichment --- plum brandy --- GC-FID-MS --- enzyme inhibition assay --- antibacterial assay --- effect-directed analysis --- bioassay --- botanicals --- health food --- protein tyrosine phosphatases (PTPs) --- PTP-MEG2 --- phloridzin --- glucose-uptake --- Eleutherococcus senticosus --- fruits --- eleutherosides --- nutri-pharmacological --- herbs --- inflammation --- docking --- NuBBE database --- chalcones --- Nacobbus aberrans --- nematicidal activity --- α-terthienyl --- stigmasterol --- quercetagetin derivatives --- 9-O-angeloyl-retronecine N-oxide --- alkaloid --- Solanaceae --- tropane --- indole --- pyrrolidine --- Datura --- terpenoid --- signaling --- chemical cue --- kairomone --- potentiation --- cytotoxic activity --- NMR --- Ononis diffusa --- Ononis variegata --- oxylipins --- toronjil --- Mexican agastache --- aromatic plants --- weld --- Reseda luteola L. --- natural yellow dye --- μ-analysis --- micro-extraction of wool --- UHPLC --- fingerprinting --- flavones --- structure elucidation --- n/a