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This book presents the frontier research of toxicology and health risk assessment of chemicals. First, it provides an overview of the current methods of evaluating safety amounts of chemicals and provides a new aspect of the principle of toxicology. Secondly, it shows recent research where the new method of health risk evaluation is adopted, followed by an integrated health risk assessment of chemicals. Finally, it describes the epigenetic inheritance of chemical impact on health throughout several generations. Estimating the safety amount of chemicals surrounding our lives is not sufficient for health risk evaluation, particularly for carcinogenic compounds, endocrine disruptors, and nano materials. The authors group has found a family of chemicals linked to ADHD through animal screening and identified its chemical nature using chemoinformatics methods. Based on these new developments, this book proposes to utilize the biomarker common to those chemicals for health risk assessment, independent of exposure routes and physiological dimensions. The book appeals to researchers and students in the field of toxicology, health risk assessment, pharmacology, and public health.
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Background -- Introduction -- Introduction to fluoro-chemistry -- Methodology and limitations -- Mapping of use of per- and polyfluorinated substances on the Nordic market -- Mapping of uses and applications of PFCs on the Nordic market -- Occurrence of per- and polyfluorinated substances -- Human health effects and related animal toxicity of perand polyfluorinated substances -- Environmental effects of per- and polyfluorinated substances -- Discussion -- Conclusions -- References -- List of abbreviations and acronyms -- Illustration of mapping of SPIN- and preregistered chemicals -- List of contacted companies/institutions -- Commercial PFC products and brands on the market -- Data contributions to "Mapping of uses and applications of PFCs on the Nordic market"--Data contributions of PFCA and PFSA in food and drinking water.
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Given the widespread presence of chemical compounds in the environment and their effects on organisms, there is an increasing need to better understand the mechanisms underlying their toxicity. This book brings together 13 chapters on a variety of topics from different areas of research in environmental pollutants toxicology. While it illustrates the toxic effects of several environmental contaminants on humans and the biota, it also introduces methodologies for assessing environmental contamination as well as remediation techniques.
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