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This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.

Parasitology. --- Biomechanics. --- Proteins . --- Bioinformatics. --- Protein Science. --- Protein Structure. --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Biological mechanics --- Mechanical properties of biological structures --- Biophysics --- Mechanics --- Contractility (Biology) --- Data processing --- Actin. --- Actomyosin --- Enginyeria de proteïnes --- Disseny de proteïnes --- Tecnologia de proteïnes --- Enginyeria bioquímica --- Enginyeria genètica

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This volume details generation of gene-edited cell lines and organisms as models for human diseases, pest control, and large animal welfare and production outcomes. Chapters guide readers through gene regulation, editing, screening of cell lines, genome editing, and an overview of the tools for efficient genome editing including; ZFNs, TALENs, and CRISPR. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step- by-step, readily reproducible protocols. Authoritative and cutting-edge, Applications of Genome Modulation and Editing aims to be a useful and practical guide for researchers to commence or advance their study in this field.

Genetics. --- Genetics and Genomics. --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Enginyeria genètica --- Regulació genètica --- Genomes --- Genoma --- Genoma humà --- Genòmica --- Biosíntesi --- Genètica molecular --- Inducció enzimàtica --- Expressió gènica --- Intervenció genètica --- Manipulació genètica --- Recombinació genètica --- ADN recombinant --- Clonatge --- Clonatge molecular --- Enginyeria de proteïnes --- Enginyeria genètica animal --- Enginyeria genètica vegetal --- Teràpia genètica --- Fecundació in vitro --- Organismes transgènics

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Food science and technology --- voedingsleer --- Food --- Microencapsulation. --- Preservation --- Quality control. --- Encapsulation, Particle --- Particle encapsulation --- Packaging --- Foods --- Primitive societies --- Dinners and dining --- Home economics --- Table --- Cooking --- Diet --- Dietaries --- Gastronomy --- Nutrition --- Microencapsulation.65 --- Antioxidants --- Enginyeria bioquímica --- Bioquímica --- Biotecnologia --- Enginyeria química --- Biosíntesi --- Enginyeria de proteïnes --- Fermentació --- Indústries biotecnològiques --- Bioreactors --- Additius alimentaris

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This book provides practical guidance on all aspects of reverse phase protein array (RPPA) technology, which permits the quantification of protein levels in cell or tissue lysates. In addition, the latest results are presented from laboratories across the world where experts are successfully running the challenging RPPA data platform. After an introductory chapter by the inventor of the RPPA technique, the demanding task of lysate preparation is explained. Subsequent chapters review printing platforms and analytical platforms and discuss antibody screening in detail. The role of RPPA data in integrative analyses is thoroughly examined, and the various applications of RPPA, for example to identify molecular targeting drugs or evaluate cancer drug efficacy, are discussed with reference to the latest knowledge. It is hoped that the book will foster the implementation of RPPA by documenting the practical details of the technology and by revealing its great potential. It will be of high value for researchers who plan to build an RPPA platform in their institute and for researchers, clinicians, and companies who use RPPA through collaboration with an existing RPPA facility.

Proteins. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Molecular biology. --- Cancer research. --- Proteins . --- Biomedical engineering. --- Microarrays. --- Pharmaceutical technology. --- Molecular Medicine. --- Cancer Research. --- Protein Science. --- Biomedical Engineering/Biotechnology. --- Pharmaceutical Sciences/Technology. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Cancer research --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Systems biology --- Enginyeria de proteïnes --- Tecnologia farmacèutica --- Farmàcia galènica --- Tècnica farmacèutica --- Tècniques farmacèutiques --- Tecnologies farmacèutiques --- Anàlisi de medicaments --- Biotecnologia farmacèutica --- Dispositius d'administració de medicaments --- Síntesi de fàrmacs --- Sistemes d'alliberament de medicaments --- Farmàcia --- Disseny de proteïnes --- Tecnologia de proteïnes --- Enginyeria bioquímica --- Enginyeria genètica

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This book provides a comprehensive overview of the basic and advanced metabolic engineering technologies used to generate natural metabolites and industrially important biomolecules. Metabolic engineering has the potential to produce large quantities of valuable biomolecules in a renewable and sustainable manner by extending or modifying biosynthetic pathways in a wide range of organisms. It has been successfully used to produce chemicals, drugs, enzymes, amino acids, antibiotics, biofuels, and industrially important pharmaceuticals. The book comprehensively reviews the various metabolites detection, extraction and biosensors and the metabolic engineering of microbial strains for the production of industrially useful enzymes, proteins, organic acids, vitamins and antibiotics, therapeutics, chemicals, and biofuels. It also discusses various genetic engineering and synthetic biology tools for metabolic engineering. In closing, the book discusses ethical, patenting and regulatory issues in the metabolic engineering of microbes. This book is a valuable source not only for beginners in metabolic engineering, but also students, researchers, biotechnology and metabolic engineering based company.

Biomedical engineering. --- Genetic engineering. --- Microbiology. --- Biochemical engineering. --- Bioethics. --- Computer simulation. --- Biomedical Engineering/Biotechnology. --- Genetic Engineering. --- Biochemical Engineering. --- Simulation and Modeling. --- Computer modeling --- Computer models --- Modeling, Computer --- Models, Computer --- Simulation, Computer --- Electromechanical analogies --- Mathematical models --- Simulation methods --- Model-integrated computing --- Biology --- Biomedical ethics --- Life sciences --- Life sciences ethics --- Science --- Bio-process engineering --- Bioprocess engineering --- Biochemistry --- Biotechnology --- Chemical engineering --- Microbial biology --- Microorganisms --- Designed genetic change --- Engineering, Genetic --- Gene splicing --- Genetic intervention --- Genetic surgery --- Genetic recombination --- Transgenic organisms --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Moral and ethical aspects --- Enginyeria biomèdica --- Enginyeria genètica --- Microbiologia --- Biologia --- Bacteriologia --- Ecologia microbiana --- Genètica microbiana --- Microbiologia agrícola --- Microbiologia aquàtica --- Microbiologia dels sòls --- Microbiologia mèdica --- Microbiologia molecular --- Protozous --- Química microbiològica --- Virologia --- Microorganismes --- Microscòpia --- Intervenció genètica --- Manipulació genètica --- Recombinació genètica --- ADN recombinant --- Clonatge --- Clonatge molecular --- Enginyeria de proteïnes --- Enginyeria genètica animal --- Enginyeria genètica vegetal --- Teràpia genètica --- Fecundació in vitro --- Organismes transgènics --- Enginyeria clínica --- Enginyeria mèdica --- Bioenginyeria --- Biofísica --- Enginyeria --- Medicina --- Electrònica mèdica --- Enginyeria de teixits --- Materials biomèdics --- Aparells i instruments mèdics