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Septic shock. --- Bacteremic shock --- Bacterial shock --- Endotoxic shock --- Endotoxin shock --- Septicemia --- Shock

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This book provides easy consultation and guidance for an appropriate understanding and management of endotoxic shock. Endotoxic shock results from a severe, generalized inflammatory response induced by bloodstream infection with gram-negative bacteria. However, endotoxin-induced inflammatory activation may be disconnected by Gram-Negative threats (e.g. Gram-Positive and yeast infections) as well as occur in multiple clinical scenarios like post-cardiac arrest syndrome and trauma, possibly due to gut barrier dysfunction and consequent endotoxin translocation. The clinical management is structured focusing and dedicating a chapter for antibiotics, corticosteroids, volume support, vasoactive and cardiostimulating drug, coagulopathy and nutritional support. In addition, this book is remarkable because describing polymixin b hemoperfusion points out molecular interactions, and hydrodynamics of Sorption. Each section includes •) brief pathophysiology; •) principles of management; •) key messages. Readers can find updated tips related to the diagnosis and management of endotoxic shock with a multidisciplinary approach drawing a pathway from endotoxin structure and source and the related pathophysiology of endotoxic shock underling the specific clinical aspect and focusing on medical clinical management of endotoxemia and extracorporeal removal. The book – written by international opinion leaders of this field – is addressed to healthcare providers working in intensive care and represents a point of reference for intensivists, infectious disease physicians, nephrologists and critical care nurses involved in the management of endotoxic shock and enriched with useful downloadable material.

Critical care medicine. --- Septic shock --- Treatment. --- Bacteremic shock --- Bacterial shock --- Endotoxic shock --- Endotoxin shock --- Septicemia --- Shock --- Intensive care --- Intensive medicine --- Medicine --- Emergency medicine --- Intensive care units

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This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent experts in the field from Europe and beyond offer new insights into risk stratification, severity assessment, and management of critically ill patients with sepsis. The principal focus is on recently developed concepts in infection management and in antibiotic use, bearing in mind that in these patients the pharmacokinetics of antibiotics are altered, affecting renal clearance and requiring dosage adjustments. The significance of the PIRO (predisposing factors, infection, response, organ dysfunction) model in the development of effective treatment strategies is emphasized. This book will be of interest and value to all who are involved in the treatment of, or research into, sepsis and MODS.

Multiple organ failure. --- Septicemia. --- Septicemia --- Multiple organ failure --- Shock --- Infection --- Systemic Inflammatory Response Syndrome --- Investigative Techniques --- Communicable Disease Control --- Public Health Practice --- Pathologic Processes --- Inflammation --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Bacterial Infections and Mycoses --- Diseases --- Pathological Conditions, Signs and Symptoms --- Public Health --- Environment and Public Health --- Health Care --- Infection Control --- Sepsis --- Methods --- Multiple Organ Failure --- Medicine --- Health & Biological Sciences --- Emergency Medicine --- Infectious Diseases --- Treatment --- Septic shock --- Treatment. --- Bacteremic shock --- Bacterial shock --- Endotoxic shock --- Endotoxin shock --- Blood poisoning --- Poisoning, Blood --- Septicaemia --- Medicine. --- Anesthesiology. --- Critical care medicine. --- Internal medicine. --- Infectious diseases. --- Respiratory organs --- Medicine & Public Health. --- Intensive / Critical Care Medicine. --- Infectious Diseases. --- Pneumology/Respiratory System. --- Internal Medicine. --- Diseases. --- Blood --- Communicable diseases --- Emerging infectious diseases. --- Pneumology. --- Medicine, Internal --- Anaesthesiology --- Surgery --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Intensive care --- Intensive medicine --- Emergency medicine --- Intensive care units --- Respiratory organs—Diseases.