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This book explores the role of endothelial progenitor cells (EPCs) in the context of regenerative medicine (RegMed). In particular, it reveals the value of RegMed as a new TM branch intended to improve the health and quality of life, by restoring, maintaining or enhancing tissue and functions of organs. The book is divided into three chapters, the first of which describes the relevance of translational medicine (TM) as a new research approach to counteract the imposing challengeof age-related diseases. Of the diverse RegMed approaches, particular attention is paid to stem/progenitor cell-based therapies, their benefits and shortcomings, as well as to the description of types of stem and progenitor cells considered for regenerative cell therapies, such as EPCs as emerging candidates for RegMed applications. In turn, the second chapter outlines the clinical relevance of EPCs as both potential predictors, diagnostic and prognostic biomarkers of age-related diseases and therapeutic agents,discussing their advantages, disadvantages, and conflicting data. Chapter three proposes a potential roadmap for revising the findings and creating a clearer picture of valid data, which can provide support for various important aspects, i.e.isolating and characterizing EPCs by establishing standardized criteria for EPC research, identifying appropriate sub-populations for cell therapy, timing, dosing, priming of cells,and defining delivery modes for different applications. The book concludes with an overview of innovative strategies that could improve the efficacy of cell therapy at all levels, including cell priming, bio-nanotechnology, and tissue engineering.
Life sciences. --- Human genetics. --- Stem cells. --- Regenerative medicine. --- Tissue engineering. --- Life Sciences. --- Stem Cells. --- Human Genetics. --- Regenerative Medicine/Tissue Engineering. --- Endothelial cells. --- Endotheliocytes --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Epithelial cells --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Medicine --- Regeneration (Biology)
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This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristics, and the third discussing its pathophysiologies. The sixteen chapters, which represent international clinical and research perspectives, highlight the importance of molecular and signaling pathways for translational basic science and clinical medicine. Additionally, the text explores new and exciting fields in vascular biology research. Comprehensive in both content and approach, Vascular Signaling in Health and Disease is ideal for graduate students, researchers, and clinicians interested in vascular biology, pneumology, and molecular biology.
Cellular signal transduction --- Endothelial cells --- Endothelial Cells --- Signal Transduction --- Biochemical Processes --- Epithelial Cells --- Cells --- Biochemical Phenomena --- Anatomy --- Chemical Phenomena --- Phenomena and Processes --- Physiology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Cellular signal transduction. --- Endothelial cells. --- Endotheliocytes --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Medicine. --- Human physiology. --- Angiology. --- Hematology. --- Systems biology. --- Cell physiology. --- Biomedicine. --- Human Physiology. --- Cell Physiology. --- Systems Biology. --- Epithelial cells --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Angiography. --- Biological models. --- Models, Biological --- Blood-vessels --- Diagnosis, Radioscopic --- Radiography, Medical --- Haematology --- Internal medicine --- Blood --- Cell function --- Cytology --- Human biology --- Medical sciences --- Human body --- Radiography --- Diseases --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology
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The Vascular Endothelium: A Holistic Approach for Oncology provides novel and integrated knowledge on the endothelial cells as a crucial component involved in the growth of different organs in both physiological and pathological conditions. By covering diverse aspects of anatomy, embryology, molecular biology and pathology, it details the important role of the endothelium for the pathogenesis of cancer and how this knowledge can improve the outcome of cancer research.
Vascular endothelium --- Endothelium, Vascular. --- Endothelial Cells. --- Neoplasms. --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Capillary Endothelial Cells --- Lymphatic Endothelial Cells --- Vascular Endothelial Cells --- Capillary Endothelial Cell --- Cell, Capillary Endothelial --- Cell, Endothelial --- Cell, Lymphatic Endothelial --- Cell, Vascular Endothelial --- Cells, Capillary Endothelial --- Cells, Endothelial --- Cells, Lymphatic Endothelial --- Cells, Vascular Endothelial --- Endothelial Cell --- Endothelial Cell, Capillary --- Endothelial Cell, Lymphatic --- Endothelial Cell, Vascular --- Endothelial Cells, Capillary --- Endothelial Cells, Lymphatic --- Endothelial Cells, Vascular --- Lymphatic Endothelial Cell --- Vascular Endothelial Cell --- Capillary Endothelium --- Vascular Endothelium --- Capillary Endotheliums --- Endothelium, Capillary --- Endotheliums, Capillary --- Endotheliums, Vascular --- Vascular Endotheliums --- Blood vessel endothelium --- Blood-vessels --- Endothelium, Vascular --- Endothelium --- Endothelins --- Cancer. --- Endothelial cells. --- Endotheliocytes --- Epithelial cells --- Vascular endothelium. --- Endothelial Cells --- Neovascularization, Pathologic --- Neoplasms --- blood supply
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