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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Endocrinology --- endocrine disrupters --- metabolism --- metabolic diseases --- lipids --- diabetes --- pancreas --- adipose tissue --- endocrine disrupters --- metabolism --- metabolic diseases --- lipids --- diabetes --- pancreas --- adipose tissue

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Following on from the highly successful inaugural 2011 conference which took place in Switzerland, Endocrine Disruptors 2012 addressed key topics related to the evaluation of adverse effects on the endocrine system and corresponding regulatory requirements. These proceedings contain all the presentations from this conference which brought together experts from academia, government, and industry from around the globe to focus on current and future trends in testing, interpretation and evaluation of test results and how this relates to or influences regulatory activities.

Endocrine disrupting chemicals --- Disrupters, Endocrine --- Disrupting chemicals, Endocrine --- Disruptors, Endocrine --- EDCs (Endocrine disrupting chemicals) --- Endocrine disrupters --- Endocrine disrupting compounds --- Endocrine disruptors --- Environmental endocrine disrupters --- Environmental endocrine disrupting chemicals --- Environmental endocrine disruptors --- Hormone disruptors --- Pollutants

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These proceedings cover all the presentations from iSmithers' inaugural Endocrine Disruptors 2011 conference which addressed key topics related to the evaluation of adverse effects on the endocrine system and corresponding regulatory requirements.

Endocrine disrupting chemicals --- Disrupters, Endocrine --- Disrupting chemicals, Endocrine --- Disruptors, Endocrine --- EDCs (Endocrine disrupting chemicals) --- Endocrine disrupters --- Endocrine disrupting compounds --- Endocrine disruptors --- Environmental endocrine disrupters --- Environmental endocrine disrupting chemicals --- Environmental endocrine disruptors --- Hormone disruptors --- Pollutants

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In 1941 the Food and Drug Administration approved the use of diethylstilbestrol (DES), the first synthetic chemical to be marketed as an estrogen and one of the first to be identified as a hormone disruptor-a chemical that mimics hormones. Although researchers knew that DES caused cancer and disrupted sexual development, doctors prescribed it for millions of women, initially for menopause and then for miscarriage, while farmers gave cattle the hormone to promote rapid weight gain. Its residues, and those of other chemicals, in the American food supply are changing the internal ecosystems of human, livestock, and wildlife bodies in increasingly troubling ways. In this gripping exploration, Nancy Langston shows how these chemicals have penetrated into every aspect of our bodies and ecosystems, yet the U.S. government has largely failed to regulate them and has skillfully manipulated scientific uncertainty to delay regulation. Personally affected by endocrine disruptors, Langston argues that the FDA needs to institute proper regulation of these commonly produced synthetic chemicals.

Endocrine disrupting chemicals --- Disrupters, Endocrine --- Disrupting chemicals, Endocrine --- Disruptors, Endocrine --- EDCs (Endocrine disrupting chemicals) --- Endocrine disrupters --- Endocrine disrupting compounds --- Endocrine disruptors --- Environmental endocrine disrupters --- Environmental endocrine disrupting chemicals --- Environmental endocrine disruptors --- Hormone disruptors --- Pollutants --- History. --- Government policy --- Endocrine Disruptors --- Environmental Exposure --- History, 20th Century --- History, 21st Century --- Adverse effects --- History

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Environmental Contaminants and Endocrine Health focuses specifically on contaminants with hormonal disrupting activities. The book provides insights into the multiple effects of endocrine-disrupting chemicals (EDCs) and their mechanism of action (MoA) on metabolism, reproduction and the multiple physiological roles of the endocannabinoid system which has recently been indicated as new target. The content systematically covers EDC sources and effects, EDCs as sources of disease and health impairment in laboratory models, EDCs as the cause of disease and health impairment in humans and wild species, and the removal of hazardous pollutants from wastewaters to highlight intervention, mitigation and adaptation for reduced threat.

Endocrine disrupting chemicals. --- Disrupters, Endocrine --- Disrupting chemicals, Endocrine --- Disruptors, Endocrine --- EDCs (Endocrine disrupting chemicals) --- Endocrine disrupters --- Endocrine disrupting compounds --- Endocrine disruptors --- Environmental endocrine disrupters --- Environmental endocrine disrupting chemicals --- Environmental endocrine disruptors --- Hormone disruptors --- Pollutants --- Endocrine disrupting chemicals --- Endocrine Disruptors --- Environmental Pollutants --- Environmental aspects.