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This book comprehensively covers prostatic artery embolization (PAE) in interventional radiology (IR). PAE is a recently developed procedure primarily for the treatment of benign prostatic hyperplasia (BPH). BPH is an extremely common problem, affecting the urination of about half of men over the age of 50. PAE is a minimally invasive IR procedure that improves urinary symptoms secondary to BPH and, unlike most available BPH treatments, carries very little risk of compromising sexual function. It should be noted, however, that PAE is known to be a very difficult procedure due to the variations in pelvic arterial anatomy and small diameter of the target vessels. Because of the inherent challenge, interventional radiologists need resources to learn how to perform PAE, so they can add this exciting new procedure to their practice. This comprehensive, yet compact, text covers everything from patient evaluation, through procedure, and finally how to deal with failure or repeat procedures. Expert authors who are responsible for more than a third of PAEs performed in the United States include best practices and detailed steps for performing PAE, with potential pitfalls and related issues considered. Readers should come away from reading the text feeling confident in being able to provide PAE to their patients, whether it be for BPH, hemorrhage, or hematuria. This is an ideal guide for interventional radiologists hoping to learn or improve their skills for PAE.

Interventional radiology. --- Interventional Radiology. --- Radiology, Interventional --- Medical radiology --- Therapeutics --- Therapeutic embolization. --- Embolization, Therapeutic --- Embolotherapy --- Hemostasis, Surgical --- Interventional radiology --- Interventional radiology .

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This book is a concise guide to vascular embolization and provides a perspective to the operator regarding embolization procedures in various clinical settings. This procedure has gained acceptance in terms of safety and efficacy with the advent of more advanced hardware like microcatheters, embolization materials and high resolution digital imaging. It is especially useful in patients with several critical co-morbid medical conditions which preclude radical surgeries as it is organ preserving, with limited complications. Therapeutic Embolization discusses indications for the procedure, materials used, established techniques, complications and outcomes of embolization in a detailed but practical manner. While it does not claim to be a comprehensive textbook, it concentrates on providing clinically relevant information on the technique suitable for cardiologists and radiologists training to use the techniques.

Vascular surgery. --- Vascular Surgery. --- Medicine. --- Cardiology. --- Medicine & Public Health. --- Therapeutic embolization. --- Embolization, Therapeutic --- Embolotherapy --- Hemostasis, Surgical --- Interventional radiology --- Heart --- Internal medicine --- Vascular surgery --- Diseases

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Lee and Watkinson's Techniques in Interventional Radiology series of handbooks describes in detail the various interventional radiology procedures and therapies that are in current practice. The series covers procedures in angioplasty and stenting, transcatheter embolization and therapy, biopsy and drainage and ablation. Forthcoming are volumes on pediatric interventional radiology and neurointerventional radiology. Each book is laid out in bullet point format, so that the desired information can be located quickly and easily. Interventional radiologists at all stages, from trainees through to specialists, will find this book a valuable asset for their practice. Transcatheter Embolisation and Therapy approaches the procedure in two ways . Section I systematically describes the techniques of transcatheter embolization and addresses the issues surrounding embolization procedures. Section II,on the other hand, presents specific organ systems and pathologies that undergo embolization therapy. Dr. David Kessel is a Consultant Radiologist at the Leeds Teaching Hospitals, UK, and Dr. Charles Ray, Jr. is Professor of Radiology and Co-Director of Research at the University of Colorado Denver Health Sciences Center, USA.

Embolization, Therapeutic -- Methods. --- Medicine. --- Therapeutic embolization. --- Therapeutic embolization --- Hemostatic Techniques --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Therapeutics --- Methods --- Embolization, Therapeutic --- Surgery & Anesthesiology --- Health & Biological Sciences --- Surgery - General and By Type --- Interventional radiology. --- Embolotherapy --- Radiology, Interventional --- Radiology. --- Neuroradiology. --- Medicine & Public Health. --- Interventional Radiology. --- Imaging / Radiology. --- Diagnostic Radiology. --- Medical radiology --- Hemostasis, Surgical --- Interventional radiology --- Radiology, Medical. --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Interventional radiology . --- Neuroradiography --- Neuroradiology --- Nervous system --- Radiological physics --- Physics --- Radiation --- Diseases

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This book provides an in-depth account of all aspects of radioembolization, a relatively novel technique based on the efficacy of radiotherapy for the treatment of liver tumors. In the past, the therapeutic radiation dose needed to treat a tumoral area has been sufficiently high to produce permanent damage to the nontumoral liver parenchyma. Radioembolization attempts to overcome this problem by combining embolization (intravascular deployment of particles) and brachytherapy (local administration of radiotherapy with the aid of a device, namely the particles themselves). The technique is based on improvements in percutaneous endovascular procedures which have allowed the deployment of small (25-35 µm) microspheres loaded with yttrium-90 that deliver high doses of beta-radiation specifically to the tumoral area. Performance of the procedure demands close familiarity with the hepatic vascular anatomy in order to ensure avoidance of vessels going to other territories. Furthermore, detailed knowledge of liver function, tumor volume, and liver vascular shunting is needed in order to calculate the appropriate therapeutic dose in each particular case. All of these topics are addressed in depth in this book, and initial clinical results are presented, showing that constant local control can be achieved with a reasonably low rate of complications. These promising results may lead to a progressive change in the therapeutic indication for radioembolization, and in some cases it could even become the therapy of choice.

Medicine & Public Health. --- Imaging / Radiology. --- Interventional Radiology. --- Nuclear Medicine. --- Hepatology. --- Oncology. --- Radiotherapy. --- Medicine. --- Medical radiology --- Interventional radiology. --- Nuclear medicine. --- Clinical medicine. --- Médecine --- Radiologie médicale --- Radiologie interventionnelle --- Médecine nucléaire --- Radiothérapie --- Médecine clinique --- Cancérologie --- Brachytherapy -- Methods. --- Embolization, Therapeutic -- Methods. --- Liver -- Cancer -- Treatment. --- Liver Neoplasms -- Radiotherapy. --- Radioisotope brachytherapy. --- Therapeutic embolization. --- Brachytherapy --- Liver Neoplasms --- Embolization, Therapeutic --- Digestive System Neoplasms --- Radiotherapy --- Hemostatic Techniques --- Liver Diseases --- Digestive System Diseases --- Neoplasms by Site --- Therapeutics --- Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Neoplasms --- Radiology, MRI, Ultrasonography & Medical Physics --- Oncology --- Medicine --- Health & Biological Sciences --- Liver --- Cancer --- Treatment. --- Embolotherapy --- Afterloading radiotherapy --- Brachyisotope therapy --- Brachytherapy, Radioisotope --- Implant radiotherapy --- Interstitial radiotherapy --- Radiology. --- Hemostasis, Surgical --- Interventional radiology --- Implants, Artificial --- Radioisotopes --- Therapeutic use --- Radiology, Medical. --- Oncology  . --- Radiation therapy --- Electrotherapeutics --- Hospitals --- Medical electronics --- Therapeutics, Physiological --- Phototherapy --- Tumors --- Medicine, Clinical --- Atomic medicine --- Radioisotopes in medicine --- Radioactive tracers --- Radioactivity --- Radiology, Interventional --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Radiological services --- Physiological effect --- Interventional radiology . --- Gastroenterology --- Radiological physics --- Physics --- Radiation

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Hereditary hemorrhagic telangiectasia (HHT) is an inherited disease that affects the blood vessels, and is characterized by direct connections between arteries and veins with no intervening capillaries. These abnormal vessels may appear in the skin as tiny red dilated blood vessels in the mouth, lips, fingers and toes. The presence of these vascular lesions in the mucosa can lead to spontaneous and recurrent nose bleeding, typically beginning in mid-childhood, and this is the most common clinical manifestation of HHT, occurring in over 90% of patients. Gastrointestinal bleeding, derived from mucocutaneous vascular lesions, affects approximately 25% of patients, almost always presenting after the age of 50. Chronic nasal and gastrointestinal bleeding can cause iron-deficiency anemia, and current therapeutic strategies are trying to minimize iron and blood transfusions. HHT patients also present large vascular lesions, known as arteriovenous malformations, that occur in internal organs like lungs, liver, and brain, and may result in life-threatening complications often related to the shunting of blood. This book not only highlights the current knowledge regarding diagnosis and treatment of HHT, but also the newest insights in the molecular basis of HHT, the understanding of which is essential for the development of new medicines or therapeutic strategies.

hereditary hemorrhagic telangiectasia --- rare diseases --- telangiectasis --- transforming growth factor-beta (TGF-β) --- Smad pathway --- gastrointestinal bleeding --- epistaxis --- nosebleeds --- tacrolimus --- nasal ointment --- genetic disease --- rare disease --- hereditary hemorrhagic telangiectasia (HHT) --- telangiectases --- mechanical damage --- sun-induced trauma --- vascular malformations --- Endoglin --- activin-receptor-like kinase 1 --- Hereditary Hemorrhagic Telangiectasia --- antithrombotic therapy --- anticoagulants --- antiplatelets --- bleeding --- safety --- HHT --- ALK1 --- endoglin --- raloxifene --- bazedoxifene --- tranexamic acid --- propranolol --- FK506 --- etamsylate --- N-acetylcysteine --- pulmonary arteriovenous malformations --- transcatheter embolotherapy --- screening --- guidelines --- Hereditary hemorrhagic telangiectasia --- pediatrics --- genotype–phenotype correlation --- arteriovenous malformation --- ENG --- ACVRL1 --- SMAD4 --- microRNA --- biomarker --- plasma --- arteriovenous malformations (AVMs) --- angiogenesis --- activin receptor-like kinase 1 (ALK1) --- transforming growth factor beta (TGF-β) --- bone morphogenetic protein (BMP) --- propranolol gel --- epistaxis severity score --- nasal endoscopy --- antiangiogenic properties --- non-coding RNAs --- microRNAs --- long non-coding RNAs --- biomarkers --- endothelial cells --- hereditary hemorrhagic telangiectasia (HHT), second-hit --- arteriovenous malformation (AVM) --- Smad4 --- inflammation --- shear stress --- vascular injury --- somatic mutation --- cell adhesion --- vascular endothelial growth factor (VEGF) --- telangiectasia --- hereditary hemorrhagic --- survival --- life expectancy --- pulmonary arteriovenous malformation --- contrast enhanced magnetic resonance angiography --- liver --- MRI --- ultrasound --- AVM --- bevacizumab --- Osler–Weber–Rendu --- hereditary hemorrhagic telangiectasia/HHT/osler’s disease --- cerebral ischemic lesions --- catheter based embolization therapy