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This book collects protocols from different areas of knowledge to assist in the identification of toxic effects exerted by different xenobiotics. At the same time as classical techniques are presented, modern techniques with alternative models to the use of animals are also presented. Given the ever-increasing exposure to different compounds and their effects on population health, the assessment of multiple endpoints is of utmost importance for better risk assessment, and this collection addresses that need. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Toxicity Assessment: Methods and Protocols aims to serve researchers in this vast field of science as they seek to better understand the mechanisms of action of different xenobiotics.

Toxicologia --- Intoxicació --- Manuals de laboratori --- Tècniques de laboratori --- Intoxicació alimentària --- Intoxicació plúmbica --- Farmacologia --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Verins --- Medicine—Research. --- Biology—Research. --- Biomedical Research. --- Xenobiòtics --- Efectes secundaris --- Efectes secundaris dels medicaments --- Bioquímica --- Productes químics

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In this book, Stefan Pieper supports doctors and therapists in easily diagnosing FQAD and in better and more adequately dealing with FQAD patients. Fluoroquinolones, as one of the most common and effective groups of antibiotics, are known to have a distinct spectrum of side effects. These adverse effects are rare in percentage terms, but frequent in absolute numbers due to the enormous quantities of prescriptions. Because they are usually quite severe and wide-ranging, they tend to run like a syndrome and have been classified by the FDA as a separate condition, the FQAD, because of their frequency, severity and risk of disability. This book presents for the first time a comprehensive description and classification of the clinical picture and a proposal for a clinical diagnostic tool based on diagnostic criteria.

Internal medicine. --- General practice (Medicine). --- Critical care medicine. --- Internal Medicine. --- General Practice / Family Medicine. --- Intensive / Critical Care Medicine. --- Intensive care --- Intensive medicine --- Medicine --- Emergency medicine --- Intensive care units --- Medicine, Internal --- Family medicine. --- Physicians (General practice) --- General practice (Medicine) --- General practitioners --- Family medicine --- Family practice (Medicine) --- Practice --- Specialties and specialists --- Antibiòtics --- Efectes secundaris dels medicaments --- Efectes adversos dels medicaments --- Reaccions adverses als medicaments --- Malalties iatrogèniques --- Al·lèrgia als medicaments --- Toxicitat dels medicaments --- Fotosensibilització (Biologia) --- Efectes secundaris --- Farmacovigilància --- Interaccions dels medicaments --- Utilització de medicaments --- Agents antiinfecciosos --- Quimioteràpia --- Antibiòtics betalactàmics --- Tetraciclines --- Additius de pinsos --- Antibiosi --- Microbiologia farmacèutica --- Medicaments antiinfecciosos --- Estreptomicina --- Cloramfenicol --- General Practice and Family Medicine. --- Intensive Care Medicine.

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This book covers all aspects of hypersensitivity to drugs, providing practical information for non-specialist physicians as well as addressing issues of interest to practitioners in different specialties and presenting the expert knowledge required by specialist allergists and immunologists. The opening, general section discusses basics such as clinical manifestations, histopathology, mechanisms, risk factors, drug hypersensitivity in particular populations, and the full range of diagnostic methods. The second part of the book provides concise information on the most important drug classes and guides the reader on how to proceed when patients present with a suspected reaction. For each drug class, the current level of evidence for use of the different diagnostic tools, including skin tests, provocation tests, and in vitro tests, is clarified, and management options, outlined. The inclusion of helpful tables and algorithms is designed to aid in decision making. Drug hypersensitivity is among the more complex allergological issues, and this book will meet the needs of general practitioners, internists, and specialists.

Dermatologic agents. --- Drugs, Dermatologic --- Dermatopharmacology --- Dermatology. --- Allergy. --- Internal medicine. --- Pharmacovigilance. --- Primary care (Medicine). --- Family medicine. --- Allergology. --- Internal Medicine. --- Drug Safety and Pharmacovigilance. --- Primary Care Medicine. --- General Practice and Family Medicine. --- Family practice (Medicine) --- General practice (Medicine) --- Medicine --- Physicians (General practice) --- Primary medical care --- Medical care --- Pharmacoepidemiology --- Medicine, Internal --- Allergic diseases --- Allergies --- Hypersensitivity --- Hypersensitivity, Immediate --- Immediate allergy --- Immediate hypersensitivity --- Immunologic diseases --- Immunoglobulin E --- Skin --- Diseases --- Medicaments dermatològics --- Efectes secundaris dels medicaments