Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Dystonia.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Stomach. --- Dystonia.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The term "dystonia" was used for the first time a hundred years ago by Oppenheim. He reported the first clinical observations, an alteration of the muscular tone and abnormal postures, as "dystonia musculorum deformans". At that time, those concerned Romanian Jewish children. Today, dystonia is recognized as a motor disorder characterized by involuntary and sustained contractions of opposing muscles causing twisting movements and abnormal postures. If dystonia is a movement disorder; other brain functions are generally not affected. This rare but serious pathology has a significant semiotic and etiological heterogeneity which makes the implementation of treatment difficult. Treatment includes surgical acts, injections of botulinum toxin and other oral substances. The major objectives of this thesis are to resume these oral drugs frequently prescribed, to highlight the evidences of their therapeutic efficacy and their role played in the treatment of dystonia. However, due to the fact that few reliable studies on oral therapies to treat dystonia exists, and, even if only anticholinergics might have proven their therapeutic efficacy, more rigorous studies are needed to improve treatment strategies and help practitioners in their professional practice. Le terme « dystonie » a été utilisé pour la première fois il y a environ 100 ans par Oppenheim. Il a rapporté les premières observations cliniques sous le nom de « dystonia musculorum deformans ». Celles-ci concernaient des enfants juifs roumains. A cette époque, il décrivait une altération du tonus musculaire et des postures anormales. La dystonie est maintenant reconnue comme un désordre moteur caractérisé par des contractions musculaires involontaires et soutenues qui engendrent des mouvements de torsion et postures anormales. La dystonie est donc un trouble du mouvement, mais les autres fonctions cérébrales ne sont en général pas touchées. Cette pathologie rare mais grave présente une importante hétérogénéité sémiologique et étiologique ce qui rend son traitement difficile à mettre en place. Le traitement comprend certains actes chirurgicaux, des injections de toxine botulique et toute une série de substances orales. Ce mémoire tend à synthétiser ces substances orales souvent prescrites, leurs preuves d'efficacité et leur place dans la stratégie de traitement de la dystonie. Cependant il existe extrêmement peu d'études fiables sur les traitements oraux de la dystonie. Seuls les anticholinergiques auraient prouvés leur efficacité dans des études randomisées contrôlées. Des études rigoureuses sont donc nécessaires afin d'améliorer les stratégies de traitement de cette maladie et aider les praticiens dans leur exercice professionnel.

Dystonia --- Cholinergic Antagonists

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Dystonia musculorum deformans

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This volume is the third in a series developed under the auspices of the World Federation of Neurology to meet the needs of neurologists who must practice medicine without many of the advantages that are often taken for granted in the industrialized world. It is targeted to neurologists practicing in low-resource environments and those who wish to practice cost-effective neurology, and addresses issues important for neurologists in developing countries that are not covered in standard textbooks. The series will update the reader in currently accepted diagnostic and management practice. Materia

Dystonia. --- Extrapyramidal disorders --- Muscles --- Diseases