Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Comprising contributions from leading lipidologists from around the world, this book presents the latest and most comprehensive knowledge on the different options for combination therapy of dyslipidemia, and includes discussion of future therapies that are currently in late stages of clinical evaluation. Dyslipidemia is a leading cause of cardiovascular morbidity and mortality and most patients with this condition fail to achieve adequate control of their serum lipid levels with monotherapy. However, recent US and European guideline recommendations, based on randomized, controlled trials, fail to discuss combination therapy options for patients with dyslipidemia. Statins remain the mainstay of drug therapy for hyperlipidemia and chapters in this book specifically examine the role of add-on therapy with different agents modulating the different lipid fractions in the blood, e.g. bile acid sequestrants, fibric acid derivatives (fibrates), omega-3 fatty acids (fish oils), inhibitors of Niemann-Pick C1 like 1 (NPC1L1) protein, cholesteryl ester transfer protein (CETP), apolipoprotein B-100 and microsomal triglyceride transfer protein (MTP), and the emerging proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. There is additional discussion of the role of non-drug therapy options such as nutraceuticals, functional foods and lipoprotein apheresis. The book also discusses the combination of antihypertensive drugs with lipid-lowering drugs in the management of cardiovascular risk in patents with dyslipidemia.

Medicine & Public Health. --- Cardiology. --- Pharmacotherapy. --- Pharmacology/Toxicology. --- Medicine. --- Toxicology. --- Médecine --- Toxicologie --- Cardiologie --- Chemotherapy, Combination. --- Dyslipoproteinemias. --- Hyperlipidemia. --- Medicine --- Health & Biological Sciences --- Cardiovascular Diseases --- Combination chemotherapy --- Combination drug therapy --- Drug therapy, Combination --- Polychemotherapy --- Hyperlipemia --- Hyperlipidaemia --- Pharmacology. --- Blood lipoproteins --- Blood lipids --- Lipids --- Metabolism --- Disorders --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Heart --- Internal medicine --- Toxicology --- Diseases --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Drug therapy --- Pharmacotherapy --- Therapeutics --- Physiological effect

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cardiovascular disease is a major cause of morbidity and mortality in developed countries. Measurement of blood of lipids and lipoproteins has become one of the most frequently performed assays in clinical chemistry laboratories, reflecting their role in the aetiology of cardiovascular disease. Pocket Reference to Comprehensive Lipid Testing and Management provides an overview of the purpose of lipid testing, diagnosis and lipid profiles as well as the goals of treatment and pharmacological management of lipid levels. The book is divided into two parts, one covering lipid testing and one covering lipid management in the prevention of cardiovascular disease.

Lipids -- Metabolism. --- Lipids. --- Medicine. --- Arteriosclerosis --- Myocardial Ischemia --- Lipid Metabolism Disorders --- Chemicals and Drugs --- Arterial Occlusive Diseases --- Heart Diseases --- Metabolic Diseases --- Vascular Diseases --- Nutritional and Metabolic Diseases --- Cardiovascular Diseases --- Diseases --- Coronary Disease --- Atherosclerosis --- Dyslipidemias --- Lipids --- Medicine --- Health & Biological Sciences --- Cardiovascular Disease --- Disease, Cardiovascular --- Diseases, Cardiovascular --- Disease, Vascular --- Diseases, Vascular --- Vascular Disease --- Diseases, Metabolic --- Thesaurismosis --- Disease, Metabolic --- Metabolic Disease --- Thesaurismoses --- Cardiac Diseases --- Cardiac Disease --- Disease, Cardiac --- Disease, Heart --- Diseases, Cardiac --- Diseases, Heart --- Heart Disease --- Arterial Obstructive Diseases --- Arterial Obstructive Disease --- Arterial Occlusive Disease --- Disease, Arterial Obstructive --- Disease, Arterial Occlusive --- Diseases, Arterial Obstructive --- Diseases, Arterial Occlusive --- Obstructive Disease, Arterial --- Obstructive Diseases, Arterial --- Occlusive Disease, Arterial --- Occlusive Diseases, Arterial --- Lipid Metabolism Disorder --- Metabolism Disorder, Lipid --- Metabolism Disorders, Lipid --- Heart Disease, Ischemic --- Ischemia, Myocardial --- Ischemic Heart Disease --- Disease, Ischemic Heart --- Diseases, Ischemic Heart --- Heart Diseases, Ischemic --- Ischemias, Myocardial --- Ischemic Heart Diseases --- Myocardial Ischemias --- Arterioscleroses --- Dyslipidemia --- Dyslipoproteinemias --- Dyslipoproteinemia --- Atherogenesis --- Atheroscleroses --- Coronary Heart Disease --- Coronary Diseases --- Coronary Heart Diseases --- Disease, Coronary --- Disease, Coronary Heart --- Diseases, Coronary --- Diseases, Coronary Heart --- Heart Disease, Coronary --- Heart Diseases, Coronary --- Cardiology. --- Medicine & Public Health. --- Heart --- Analysis. --- Diagnosis. --- Internal medicine

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. This book chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future.

Atherosclerosis. --- Anticholesteremic agents. --- Statins (Cardiovascular agents) --- Hydroxymethylglutaryl coenzyme A reductases --- Statin drugs --- Anticholesterol drugs --- Antihypercholestermic agents --- Cholesterol inhibitors --- Cholesterol-lowering drugs --- Hypocholesteremic agents --- Inhibitors --- Anticholesteremic agents --- Enzyme inhibitors --- Antilipemic agents --- Arteriosclerosis --- Atherosclerosis --- Therapeutics --- Hypolipidemic Agents --- Hyperlipidemias --- Sterols --- Cholestenes --- Lipid Regulating Agents --- Membrane Lipids --- Dyslipidemias --- Cholestanes --- Antimetabolites --- Lipids --- Arterial Occlusive Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Steroids --- Chemicals and Drugs --- Molecular Mechanisms of Pharmacological Action --- Vascular Diseases --- Lipid Metabolism Disorders --- Therapeutic Uses --- Metabolic Diseases --- Pharmacologic Actions --- Polycyclic Compounds --- Cardiovascular Diseases --- Chemical Actions and Uses --- Nutritional and Metabolic Diseases --- Diseases --- Cholesterol --- Drug Therapy --- Hypercholesterolemia --- Anticholesteremic Agents --- Atherogenesis --- Atheroscleroses --- Chylomicron Remnants --- Plaque, Atherosclerotic --- Anticholesteremic Drugs --- Anticholesteremics --- Inhibitors, Cholesterol --- Cholesterol Inhibitors --- Hypocholesteremic Agents --- Agents, Anticholesteremic --- Agents, Hypocholesteremic --- Drugs, Anticholesteremic --- Elevated Cholesterol --- High Cholesterol Levels --- Hypercholesteremia --- Cholesterol Level, High --- Cholesterol Levels, High --- Cholesterol, Elevated --- Cholesterols, Elevated --- Elevated Cholesterols --- High Cholesterol Level --- Hypercholesteremias --- Hypercholesterolemias --- Level, High Cholesterol --- Levels, High Cholesterol --- Cholesterol, Dietary --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Disease --- Pharmaceutical Preparations --- Epicholesterol --- Nutritional Physiological Phenomena --- Cardiovascular Disease --- Disease, Cardiovascular --- Diseases, Cardiovascular --- Cardiology --- Compounds, Polycyclic --- Hydrocarbons, Cyclic --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Pharmacological and Toxicological Phenomena --- Diseases, Metabolic --- Thesaurismosis --- Disease, Metabolic --- Metabolic Disease --- Thesaurismoses --- Therapeutic Effects --- Therapeutic Effect --- Therapeutic Use --- Effect, Therapeutic --- Effects, Therapeutic --- Use, Therapeutic --- Uses, Therapeutic --- Lipid Metabolism Disorder --- Metabolism Disorder, Lipid --- Metabolism Disorders, Lipid --- Disease, Vascular --- Diseases, Vascular --- Vascular Disease --- Pharmacological Mechanisms of Action --- Catatoxic Steroids --- Steroid --- Steroids, Catatoxic --- Arterial Obstructive Diseases --- Arterial Obstructive Disease --- Arterial Occlusive Disease --- Disease, Arterial Obstructive --- Disease, Arterial Occlusive --- Diseases, Arterial Obstructive --- Diseases, Arterial Occlusive --- Obstructive Disease, Arterial --- Obstructive Diseases, Arterial --- Occlusive Disease, Arterial --- Occlusive Diseases, Arterial --- Lipid --- Antimetabolite --- Dyslipidemia --- Dyslipoproteinemias --- Dyslipoproteinemia --- Cell Membrane Lipid --- Cell Membrane Lipids --- Membrane Lipid --- Lipid, Cell Membrane --- Lipid, Membrane --- Lipids, Cell Membrane --- Lipids, Membrane --- Membrane Lipid, Cell --- Membrane Lipids, Cell --- Cell Membrane --- Membranes --- Lipid Regulating Drugs --- Agents, Lipid Regulating --- Drugs, Lipid Regulating --- Regulating Agents, Lipid --- Regulating Drugs, Lipid --- Sterol --- Antihyperlipemics --- Antihyperlipidemics --- Antilipemic Drugs --- Antilipemics --- Hypolipidemic Drugs --- Antihyperlipidemic --- Antilipemic --- Antilipemic Agents --- Antilipemic Drug --- Hypolipidemic Agent --- Hypolipidemic Drug --- Agent, Hypolipidemic --- Agents, Antilipemic --- Agents, Hypolipidemic --- Drug, Antilipemic --- Drug, Hypolipidemic --- Drugs, Antilipemic --- Drugs, Hypolipidemic --- Arterioscleroses --- Therapy --- Treatment --- Therapeutic --- Therapies --- Treatments --- Hyperlipidemia --- Lipemia --- Lipidemia --- Hyperlipemia --- Hyperlipemias --- Lipemias --- Lipidemias --- antagonists & inhibitors --- drug therapy --- therapeutic use --- therapy --- Statins (Cardiovascular agents). --- therapeutic use. --- drug therapy. --- etiology. --- adverse effects. --- complications.