Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Ligand binding (Biochemistry) --- Biochemie: chemische bindingen --- Binding, Ligand (Biochemistry) --- Biochemistry --- Dye-ligand affinity chromatography --- Radioligand assay --- Ligands (biochimie) --- Fixation --- Fixation.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This series encompasses design, synthesis, application, and analytical methods (including clinical and in vitro) for the study of these critical interactions. As our understanding of the genome and proteome expands, general developments in the field of DNA sequence specific interaction are likely to play an increasingly important role. Accordingly, manuscripts have been solicited from experts covering a diverse range of fields, reflecting the cross-disciplinary and dynamic nature of the series. Volume 4 describes work on the modification of DNA by AT specific anticancer drugs, DNA alky

DNA-ligand interactions. --- Ligand binding (Biochemistry) --- Binding, Ligand (Biochemistry) --- Biochemistry --- Dye-ligand affinity chromatography --- Radioligand assay --- Binding, DNA-ligand --- DNA-ligand binding --- Interactions, DNA-ligand

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Biosensors are becoming increasingly important bioanalytical tools in the pharmaceutical, biotechnology, food, and other consumer oriented industries. The technology, though well developed in Europe, is slowly developing and has begun to generate interest in the United States only over the past couple of years. Research is now being directed toward the development of biosensors that are versatile, economical, and simple to use. Engineering Biosensors is a comprehensive introduction to biosensors that includes numerous illustrations to further explain the main concepts and practical exa

Biosensors. --- Ligand binding (Biochemistry). --- Basic Sciences. Biotechnology --- Biotechnology (General). --- Engineering --- Electronics --- Ligand binding (Biochemistry) --- Binding, Ligand (Biochemistry) --- Biochemistry --- Dye-ligand affinity chromatography --- Radioligand assay --- Biodetectors --- Biological detectors --- Biological sensors --- Biomedical detectors --- Biomedical sensors --- Detectors --- Medical instruments and apparatus --- Physiological apparatus

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powerful bioinformatic tools, to determine the gene variants that contribute to various multifactorial diseases and genes that exist in certain infectious agents but not humans. As a consequence, this will allow us to define the most appropriate levels for drug intervention. It can be expected that the number of potential drug targets will increase, possibly by a factor of 10 or more. Nevertheless, sequencing the human genome or, for that matter, the genome of other species will only be the starting point for the understanding of their biological function. Structural genomics is a likely follow-up, combined with new techniques to validate the therapeutic relevance of such newly discovered targets. Accordingly, it can be expected that in the near future we will witness a substantial increase in novel putative targets for drugs. To address these new targets effectively, we require new approaches and innovative tools. At present, two alternative, yet complementary, techniques are employed: experimental high-throughput screening (HTS) of large compound libraries, increasingly provided by combinatorial chemistry, and computational methods for virtual screening and de novo design. As kind of status report on the maturity of virtual screening as a technique in drug design, the first workshop on new approaches in drug design and discovery was held in March 1999, at Schloß Rauischholzhausen, near Marburg in Germany. More than 80 scientists gathered and discussed their experience with the different techniques. The speakers were invited to summarize their contributions together with their impressions on the present applicability of their approach. Several of the speakers followed this request which is summarized in this publication.

Drugs --- High throughput screening (Drug development) --- Ligand binding (Biochemistry) --- Design --- Computer simulation. --- Pharmacy. --- Chemistry. --- Computer Applications in Chemistry. --- Chemoinformatics. --- Chemical informatics --- Chemiinformatics --- Chemoinformatics --- Chemistry informatics --- Chemistry --- Information science --- Computational chemistry --- Medicine --- Materia medica --- Pharmacology --- Data processing --- High throughput testing (Drug development) --- HRS (Drug development) --- Drug development --- Pharmaceutical chemistry --- Binding, Ligand (Biochemistry) --- Biochemistry --- Dye-ligand affinity chromatography --- Radioligand assay --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Pharmacy

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

A NATO Advanced Research Workshop entitled New Methods for the Study of Molecular Aggregates was held at Tbe Lodge at Kananaskis Village, Alberta, Canada from 16 -20 June 1996. In fact the meeting was entirely concerned with the problem of analyzing biomolecular complexes, so the title of these proceedings has been altered to give a more precise description of the content. Tbe workshop was hosted by the time-of-flight group of the Department of Physics at the University of Manitoba, and was attended by 64 participants from around the world. '!venty-one invited talks were given and 27 papers were presented as posters. Of the 48 contributions, 22 papers (12 orals, 10 posters) are included in these proceedings. Tbe subject of the conference was the investigation of noncovalent biomolecular complexes, with particular focus on the application of mass spectrometry to their characterization. '!vo new ionization techniques introduced in the late 1980s, electrospray ionization (ES I) and matrix-assisted laser desorptionlionization (MALDI), resulted in a breakthrough in mass spectrometry, enabling its use in molecular weight and primary structure determination of biopolymers larger than 100 kDa. Recently it has been discovered that ESI mass spectrometry mayaiso be used to characterize complexes containing noncovalent interactions, thus opening new perspectives for supramolecular chemistry. ESI mass spectrometry has the advantage that the sampie is introduced from a homogenous solution which can be maintained at near physiological conditions of pR, concentration, and temperature.

Ligand binding (Biochemistry) --- Biomolecules --- Complex chemicals --- Chemical ionization mass spectrometry --- Research --- Methodology --- Biochemistry. --- Analytical chemistry. --- Biochemistry, general. --- Analytical Chemistry. --- Analysis, Chemical --- Analytic chemistry --- Chemical analysis --- Chemistry, Analytic --- Chemistry --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Composition --- Chemical ionization mass spectrometry. --- Mass spectrometry. --- Biological molecules --- Molecules --- Molecular biology --- Mass spectra --- Mass spectrograph --- Mass spectroscopy --- Mass spectrum analysis --- Mass (Physics) --- Nuclear spectroscopy --- Spectrum analysis --- Mass spectrometry --- Binding, Ligand (Biochemistry) --- Biochemistry --- Dye-ligand affinity chromatography --- Radioligand assay --- Methodology. --- Ligand binding (Biochemistry) - Research - Methodology --- Biomolecules - Research - Methodology --- Complex chemicals - Research - Methodology