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Clinically-oriented and up-to-date, Dry Eye Diseases focuses on the latest diagnostic techniques, management guidelines, and treatment options for dry eye disorders. This consolidated resource provides guidance on the clinical assessment of patients presenting with dry eye symptoms as well as a global perspectives on the use of FDA and off-label products. Practicing and trainee ophthalmologists and optometrists will find this an indispensable resource for understanding this complex disorder.

Dry eye syndromes. --- Dry Eye Syndromes --- diagnosis. --- Dry eye disorders --- Lacrimal apparatus --- Syndromes --- Diseases --- diagnosis --- therapy --- Dry Eye --- Dry Eye Disease --- Evaporative Dry Eye --- Evaporative Dry Eye Disease --- Evaporative Dry Eye Syndrome --- Dry Eye Diseases --- Dry Eye Syndrome --- Dry Eye, Evaporative --- Dry Eyes --- Evaporative Dry Eyes --- Dry eye syndromes

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In the biochemical reactions that take place within all living beings, species called free radicals are generated. Denham Harman, in his study on the origin and evolution of life (Harman, 2001), proposes that these species are amongst the causes of the origin of life on our planet. Oxygen is a molecule that provides the primary source of energy in aerobic organisms and therefore is key to the development and evolution of life. On the one hand, it gives rise to life; on the other, due to its ability to form different free radicals, it is capable of damaging essential structures for development. To combat these radicals, our biological systems have developed antioxidant defenses. However, when the balance between free radicals and antioxidant defenses is broken in favor of the former, a phenomenon called oxidative stress occurs, which ends up damaging molecules such as DNA, proteins, carbohydrates, and lipids (Sies, 1983) (Halliwell and Gutteridge, 1985). This phenomenon is implicated both in the development of diseases and in their progression. In addition, inflammation phenomena are also involved in most pathologies, which, although they are essential for tissue repair and immunity, turn against our bodies when they become excessively active. For these reasons, in this special edition we showcase an extensive knowledge of the effects of oxidative stress and inflammation both in diseases such as aging, or for its role in health.

Public health & preventive medicine --- diospyrin --- lipopolysaccharide --- anti-inflammation --- macrophages --- nitric oxide --- cytokine --- calcium --- CHOP --- Fas --- p38 MAPK --- Astragalus mongholicus Bunge --- danazol --- telomere --- telomerase --- aging --- diabetic kidney disease --- oxidative stress --- redox imbalance --- hyperimmunized milk --- exercise --- inflammation --- intestinal permeability --- acute respiratory distress syndrome --- antiplatelet --- aspirin --- therapy --- gender --- membrane erythrocyte --- hydroperoxides --- biomarker --- DPPP --- DPH --- TMA --- cardiovascular disease --- data analysis --- precision–recall --- Mediterranean diet --- Oriental diet --- nutrition --- polyphenols --- microbiota --- health --- n-3 PUFAs --- endogenous antioxidants --- anti-inflammatory response --- cardiovascular diseases --- dry eye syndrome --- corneal damage --- tear lipidome --- 5-lipoxigenase --- leukotriene B4 --- prostaglandins --- dimethyl sulfoxide --- zileuton --- air pollution --- soot --- particulate matter --- lung inflammation --- functional groups --- microglia --- porcine liver decomposition product --- lysophospholipids --- mild cognitive impairment --- dementia --- neuroinflammation --- cytokines --- oxygen reactive species --- caloric restriction --- oxidative balance --- adiponectin --- plasma --- white adipose tissue --- experimental model --- anti-inflammatory diets --- inflammatory response --- chronic inflammation --- low grade chronic inflammation --- inflammatory models --- cyclophosphamide --- doxorubicin --- docetaxel --- paclitaxel --- n/a --- precision-recall