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This book provides an updated analysis of rectal artesunate as a pre-referral treatment for severe malaria caused by Plasmodium falciparum. It evaluates the findings from the Community Access to Rectal Artesunate for Malaria (CARAMAL) project, highlighting discrepancies between earlier clinical trials and more recent observational studies. The World Health Organization's recommendations on the administration of artesunate are discussed, emphasizing the need for immediate referral to appropriate healthcare facilities following initial treatment. The text explores various challenges and limitations in the application of rectal artesunate, including issues related to healthcare systems, referral completion rates, and the emergence of artemisinin resistance. The book aims to inform healthcare professionals and policymakers about the efficacy and implementation challenges of rectal artesunate, particularly in resource-limited settings.
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