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The currently available means of combating fungal infections are still weak and clumsy. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. Interestingly, several novel antifungal drug targets have already been identified and validated. However, it is too early to expect any novel antifungal drug as drug discovery programs are still in their infancy. In addition to classical and genomic approaches to drug discovery, traditional knowledge derived from natural products and phytomedicine can provide a multitude of alternative modes of combating fungal infection. This book comprises 20 chapters on various aspects pertaining to fungal diseases in human and animals, their reservoir, fungal pathogenesis, their management and recent advances in their treatment. Issues of antifungal drug toxicity, especially nephrotoxicity, are also discussed. The development of resistance in fungal pathogens, including multidrug resistance and its mechanism, is dealt with in two chapters. Diverse diagnostic approaches to fungal infections are also reviewed. The combinational drug strategies used in combating invasive fungal infections are addressed in detail. The management of pulmonary mycoses in stem cell transplantation is also given special focus. Novel antifungal drugs (synthetic and herbal), fungal vaccines, and metabolic pathways as drug targets are discussed in detail in three different chapters. Subsequently the roles of innate immunity, cytokine therapy and immunomodulators in the treatment of fungal infections are elaborated upon. As novel drug delivery systems have a great potential for modifying the pharmacokinetics of medications, the last chapter takes this fact into consideration in its examination of state-of-the-art delivery systems in controlling fungal infections.

Drug resistance, Fungal. --- Mycoses -- Treatment. --- Mycoses. --- Mycoses --- Bacterial Infections and Mycoses --- Anti-Infective Agents --- Drug Resistance, Microbial --- Drug Resistance, Fungal --- Antifungal Agents --- Microbiological Phenomena --- Drug Resistance --- Diseases --- Therapeutic Uses --- Pharmacologic Actions --- Pharmacological Phenomena --- Phenomena and Processes --- Physiological Phenomena --- Chemical Actions and Uses --- Chemicals and Drugs --- Medicine --- Biology --- Microbiology & Immunology --- Infectious Diseases --- Health & Biological Sciences --- Treatment --- Chemotherapy --- Fungal diseases --- Fungal infections --- Fungous diseases --- Mycosis --- Mycotic diseases --- Mycotic infections --- Medicine. --- Immunology. --- Medical microbiology. --- Pharmacology. --- Microbiology. --- Biomedicine. --- Medical Microbiology. --- Pharmacology/Toxicology. --- Medical mycology --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Immunobiology --- Life sciences --- Serology --- Microbial biology --- Microorganisms --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Drugs --- Pharmacy --- Physiological effect

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With the growing frequency of fungal infections even as resistance to existing antifungal agents increases, methods for finding novel drug targets and evaluating antifungal resistance have become more important than ever. In Antifungal Agents: Methods and Protocols, expert scientists describe in detail the state-of-the-art molecular methods they have optimized for studying antifungal resistance, for discovering and evaluating both new and existing antifungal drugs, and for understanding the host response and immunotherapy of such agents. Many of the protocols were developed in the laboratory and, when a method is limited to specific organisms, include alternative techniques to expand their application. The protocols follow the successful Methods in Molecular Medicine™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and highly practical, Antifungal Agents: Methods and Protocols offers clinician-scientists, microbiologists, and molecular biologists the productive tools they need today in order to understand and successfully develop new therapeutic agents for yeast, mold, and fungal infections.

Antifungal agents --- Medical mycology --- Mycoses --- Candida albicans --- Antifungal Agents --- Candidiasis --- Drug Resistance, Fungal --- Models, Animal --- Research --- Methodology --- Immunotherapy --- genetics --- immunology --- therapeutic use --- therapy --- Antifungal agents -- Research -- Methodology. --- Electronic books. -- local. --- Medical mycology. --- Mycoses -- Immunotherapy. --- Drug Resistance, Microbial --- Anti-Infective Agents --- Investigative Techniques --- Candida --- Biology --- Therapeutic Uses --- Biological Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Mitosporic Fungi --- Bacterial Infections and Mycoses --- Drug Resistance --- Microbiological Phenomena --- Yeasts --- Fungi --- Phenomena and Processes --- Pharmacological Phenomena --- Natural Science Disciplines --- Diseases --- Pharmacologic Actions --- Eukaryota --- Physiological Phenomena --- Disciplines and Occupations --- Chemical Actions and Uses --- Organisms --- Chemicals and Drugs --- Genetics --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Methodology. --- Immunotherapy. --- 57.08 --- 57.08 Biological techniques. Experimental methods. Equipment --- Biological techniques. Experimental methods. Equipment --- Fungal diseases --- Fungal infections --- Fungous diseases --- Mycosis --- Mycotic diseases --- Mycotic infections --- Anti-fungal agents --- Antimycotics --- Fungal inhibitory agents --- Inhibitory agents, Fungal --- Therapeutic fungicides --- Medical microbiology --- Mycology --- Pathogenic fungi --- Anti-infective agents --- Fungicides --- Emerging infectious diseases. --- Infectious Diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Antifungal agents - Research - Methodology --- Mycoses - Immunotherapy --- Candida albicans - genetics --- Candida albicans - immunology --- Antifungal Agents - therapeutic use --- Candidiasis - immunology --- Candidiasis - therapy --- Drug Resistance, Fungal - immunology