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Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. Covers reviews of methodology and research in all as
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DNA-protein interactions. --- Proteins --- Protein binding. --- DNA-Binding Proteins --- genetics.
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Transcription factors --- DNA-protein interactions --- Genetic regulation --- Congresses. --- Congresses. --- Congresses.
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DNA-protein interactions --- DNA-Binding Proteins. --- Protein Binding
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The pivotal role played by transcription factors in regulating gene expression has ensured that their study is a major area of current research activity. This book provides a comprehensive description of all the approaches and methods required to identify, isolate and characterize transcription factors. Starting with a specific DNA sequence, these protocols allow the detection and identification of proteins that bind to it and detailed analysis of the DNA binding site. This is followed by procedures for the functional assay of transcription factors and their purification. Also included are methods for the characterization of transcription factor genes, including DNA cloning. The analysis of transcription factors is of central interest to all molecular biologists involved in studying gene expression, making this book an important text for a wide range of researchers from postgraduate students to established scientists.
Transcription Factors --- DNA-protein interactions --- Genetic regulation --- Transcription factors --- Régulation génétique --- Facteurs de transcription --- physiology --- DNA-protein interactions. --- Genetic regulation. --- Transcription factors. --- physiology. --- Régulation génétique
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The structure, function and reactions of nucleic acids are central to molecular biology and medicine and are crucial for understanding of the ever-expanding range of complex biological processes involved which are central to life. Revised, extended, updated and lavishly illustrated, this 4th Edition of Nucleic Acids in Chemistry and Biology is a long-awaited standard text for teaching and research in nucleic acids science. It maintains the close integration of chemistry and biology that characterised the earlier editions and contains a major expansion largely focused on the burgeoning growth of RNA science. Written by an international team of leading experts, all with extensive teaching experience, this 4th Edition provides up-to-date and extended coverage of the reactions and interactions of RNA and DNA with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecule-based introduction to the structure and biological roles of DNA and RNA and the basics of Genes and Genomes. New key chapters are devoted to non-coding RNA, nucleic acids sequencing, nucleic acid therapeutics, in vitro evolution and aptamers, and protein-RNA interactions. The text is linked to an extensive list of references to make it a definitive reference source. This authoritative volume presents topics in an integrated manner and readable style with full colour illustrations throughout. It is ideal for graduate and undergraduate students of chemistry and biochemistry, biophysics and biotechnology, and molecular biology and medicine. It will be a guidebook for new researchers to the field of nucleic acids science.
Nucleic acids. --- Genomes. --- RNA. --- RNA-protein interactions. --- DNA-protein interactions. --- Acides nucléiques --- Génome --- ARN --- Interactions ARN-protéine. --- Interactions ADN-protéine.
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