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DNA Viruses: A Practical Approach groups together the major experimental methods currently employed to study DNA viruses, from the fundamentals of virus culture to novel techniques such as surface plasmon resonance spectrometry and realtime PCR analysis of drug resistance mutations in clinical isolates. Chapter 1 provides an overview of the extraction, purification and characterizations of virus DNA, but also covers the fundamentals of DNA virus culture. Chapters 2 and 3 describe approaches to the molecular investigation and mutagenesis of DNA virus genomes. Chapter 4 considers DNA virus replication and then chapters 5 & 6 describe methods to study transcription control. Chapters 7 to 9 consider aspects of the pathogenesis of DNA virus infections. The final chapter describes the current technology being applied to the development of DNA virus vectors for gene delivery. This volume will therefore be of interest to all those working on DNA viruses whether in academia, industry or clinical research.

DNA viruses. --- Deoxyribonucleic acid viruses --- Viruses, DNA --- Viruses --- General virology --- PCR (polymerase chain reaction) --- mutageniteit --- virologie --- DNA (deoxyribonucleic acid) --- moleculaire biologie --- spectrometrie --- Dna virus infections --- Dna viruses --- Dna viruses, isolation & purification. --- Virology. --- Isolation & purification. --- Physiology.

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Human papillomavirus (HPV) is one of the most common causes of sexually transmitted diseases worldwide, both in men and women. This book provides the scientific background needed to understand the natural history and pathogenesis of HPV infection and offers discussion of its clinical features, diagnosis, treatment and prevention. It begins with chapters covering the epidemiology, virology, history and transmission of the infection, as well as its pathogenesis and clinical features. Following a discussion of the relationship between HPV and cancer, chapters in the second half of the book look at diagnosis, testing and treatment. The book concludes with detailed coverage of the prevention of HPV through worldwide vaccination programmes.

Cervix uteri. --- Papillomaviruses -- Infections. --- Papillomaviruses -- Vaccination. --- Papillomaviruses. --- Papillomaviruses --- Tumor Virus Infections --- DNA Virus Infections --- Virus Diseases --- Diseases --- Papillomavirus Infections --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- HPV (Virus) --- Human papilloma virus --- Human wart virus --- Infectious human wart virus --- Papilloma viruses --- Papillomaviridae --- Papillomavirus --- Papovaviruses --- Wart virus --- Oncogenic DNA viruses

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Adenovirus epithelial keratitis and Thygeson's superficial punctate keratitis (TSPK) are apparently disparate diseases. While adenovirus eye infections are very common, caused by a known agent, and highly infectious, TSPK is comparatively rare, of unknown causation, and seemingly non-contagious. Despite these differences, the two diseases are often confused in clinical practice owing to the similarity between adenovirus epithelial infiltrates and ‘coarse’ epithelial TSPK lesions. This book presents the morphological features, dynamics, and sequelae of adenovirus and Thygeson's keratitides captured at high magnification in the living human cornea. It thereby fills the existing void between conventional photographs and slit-lamp observations. Case reports demonstrate the importance of patient history in differential diagnosis, illustrate the need for familiarity with early manifestations of adenovirus infections, and assist in the diagnosis of rare variants of TSPK. Furthermore, the detailed observations on the natural course of the diseases ensure that the book will serve not only as a diagnostic tool but also as a reference when evaluating the effects of potential new treatments.

Keratitis. --- Cornea --- Keratitis --- Corneal Diseases --- Medicine --- Epithelium --- Adenoviridae Infections --- Health Occupations --- Tissues --- DNA Virus Infections --- Anterior Eye Segment --- Eye Diseases --- Eye --- Disciplines and Occupations --- Virus Diseases --- Diseases --- Anatomy --- Sense Organs --- Epithelium, Corneal --- Adenovirus Infections, Human --- Corneal Opacity --- Pathology --- Health & Biological Sciences --- Ophthalmology & Optometry --- Inflammation --- Medicine. --- Ophthalmology. --- Medicine & Public Health.

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This book addresses the unique features of four microorganisms that constitute the top bioterror threat agents: Bacillus anthracis; Yersinia pestis, Francisella tularensis and Orthopoxviruses. Side-by-side updated information about their pathogenisis, virulence and epidemiology is provided in a single volume, allowing for evaluation of common features as well as common strategies for defense. Classical microbiological as well as genomic, proteomic & transcriptomic approaches towards development of strategies of novel prophylactic and post-exposure treatment and related aspects of diagnostics and bioforensics are covered. Written by top scientists, this book will be of major interest to all researchers interested in the intricate biology of highly pathogenic microorganisms, to scientists and clinicians interested in microbial pathogenesis and prevention, and to a wide range of professionals dealing with the various aspects of bio-defense.

Biological weapons. --- Communicable diseases. --- Medical microbiology. --- Pathogenic microorganisms. --- Pathogenic microorganisms --- Chordopoxvirinae --- DNA Virus Infections --- Bacterial Infections and Mycoses --- Organisms --- Orthopoxvirus --- Bacterial Infections --- Bacteria --- Poxviridae Infections --- Virus Diseases --- Diseases --- Poxviridae --- DNA Viruses --- Vertebrate Viruses --- Viruses --- Biology --- Microbiology & Immunology --- Health & Biological Sciences --- Disease-causing microorganisms --- Micro-organisms, Pathogenic --- Pathogens --- Medicine. --- Vaccines. --- Microbiology. --- Bacteriology. --- Microbial genetics. --- Microbial genomics. --- Biomedicine. --- Medical Microbiology. --- Vaccine. --- Eukaryotic Microbiology. --- Microbial Genetics and Genomics. --- Microorganisms --- Medical microbiology --- Virulence (Microbiology) --- Genomics --- Microbial genetics --- Genetics --- Microbiology --- Biologicals --- Microbial biology

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Frontiers in Viral Hepatitis provides a compilation of the research from over 40 key opinion leaders in the field of Hepatitis. The book focuses on the latest advances in the search for new, more effective therapeutic options and related topics in viral hepatitis. These include regulatory issues, epidemiology, and emerging viruses; immunology and vaccines; viral hepatitis B and C infections in children; genetics pathology and viral diagnosis; cell systems and animal models; novel therapeutics for hepatitis B and C; resistance and therapeutic strategies in humans; and prevention and treatment options for hepatocellular carcinoma. The breadth of information published in this volume provides insight into current prevention and treatment options. Recent advances in our understanding of the molecular biology, immunology and pathogenesis of hepatitis viruses have accelerated at a remarkable rate, offering a more comprehensive perspective on hepatitis.

Human medicine --- Hepatitis, Viral, Human --- Liver Neoplasms --- Flaviviridae Infections --- Drug Resistance, Microbial --- Virus Physiological Phenomena --- Hepadnaviridae Infections --- Adenocarcinoma --- Carcinoma, Hepatocellular --- Hepatitis C --- Drug Resistance, Viral --- Hepatitis B --- Hepatitis --- Microbiological Phenomena --- Digestive System Neoplasms --- Drug Resistance --- Virus Diseases --- Carcinoma --- DNA Virus Infections --- RNA Virus Infections --- Liver Diseases --- Digestive System Diseases --- Neoplasms by Site --- Diseases --- Phenomena and Processes --- Neoplasms, Glandular and Epithelial --- Pharmacological Phenomena --- Neoplasms --- Neoplasms by Histologic Type --- Physiological Phenomena