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With the completion of the ""Human Genome Project"" and the cloning and complete molecular description of the known myelin genes, the stage has been set for a detailed understanding of the biology of myelin, the disease processes affecting myelin and the potential for myelin repair and regeneration. Myelin Biology and Disorders brings together in one place, the recent advances in molecular and cellular biology along with visual data from MRI, confocal microscopy and high voltage EM techniques to provide new insights into disease mechanisms. This book represents a unique research referen

Neuropathology --- Demyelination. --- Myelin sheath. --- Myelin sheath - Diseases - Animal models. --- Myelin sheath - Pathophysiology. --- Myelin sheath. Myelin sheath--Pathophysiology. Myelin sheath--Diseases--Animal models. Demyelination.

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Diseases --- Animal models in research --- Animal models --- Biogeneeskunde. --- Biomédecine. --- Art de l'ingénieur / en biomédecine. --- Biomedische ingenieurskunst. --- Medical sciences --- Research --- Diseases - Animal models

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to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neu- psychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further research using animals is necessary and why animal models of psychi- ric and neurologic disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. However, when the distress, discomfort, or pain to the animals outweighs the anticipated gains for human welfare, then the research is not ethical and should not be carried out.

Nervous system -- Diseases -- Animal models. --- Nervous system --- Diseases --- Models, Biological --- Models, Animal --- Animal Diseases --- Disease Models, Animal --- Nervous System Diseases --- Models, Theoretical --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Medicine --- Neurology --- Health & Biological Sciences --- Animal models --- Animal models. --- Organs (Anatomy) --- Neurosciences --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences

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Animal Models in Cardiovascular Research covers both historical and recent advances in our understanding of the cardiovascular system from studies conducted in animal models. The last decade has seen an explosion in the use of very specialized congenic and transgenic animal models that were not described in the previous two editions. The results of many of these studies provide a sometime bewildering array of redundant, overlapping and competing molecular pathways demanding further study. This third edition is designed to provide a better basis for understanding and using animal models in the current climate of background knowledge and information. The first and second editions of Animal Models in Cardiovascular Research emphasized normal cardiovascular parameters and the cardiovascular effects of a wide variety of drugs commonly used for restraint, anesthesia and pain control in the various animal species. The third edition is focused on the avalanche of genetic, molecular and protein-based information generated from the use of both congenic and transgenic animal models. Updated and expanded chapters provide new information generated from classical, congenic and transgenic animal models used to study ischemic heart disease, cardiomyopathy, heart failure, hypertension and atherosclerotic disease. Completely new chapters in this third edition describe the techniques, problems and pitfalls associated with the measurement of cardiac and vascular function and ventricular/arterial coupling dynamics in various animal models. There is a new chapter detailing problems and pitfalls associated with isolated heart preparations and another describing animal models for the study of neurohumeral and CNS control of the cardiovascular system.

Cardiovascular diseases. --- Cardiovascular system -- Diseases -- Animal models. --- Cardiovascular system -- Drug effects. --- Cardiovascular system -- Research -- Methodology. --- Disease models, Animal. --- Cardiovascular system --- Disease Models, Animal --- Cardiovascular Diseases --- Cardiovascular System --- Research --- Science --- Diseases --- Animal Diseases --- Anatomy --- Models, Animal --- Models, Biological --- Natural Science Disciplines --- Investigative Techniques --- Models, Theoretical --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Physiology --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Animal models --- Methodology --- Animal models. --- Methodology. --- Circulatory system --- Vascular system --- Life sciences. --- Cardiology. --- Animal physiology. --- Life Sciences. --- Animal Physiology. --- Biomedicine general. --- Blood --- Circulation --- Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Heart --- Internal medicine --- Animal physiology --- Animals --- Biology --- Health Workforce --- Biomedicine, general.

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Muscular dystrophy --- Muscles --- Genetic aspects --- Congresses --- Animal models --- Diseases --- 591.2 --- 616.74 --- 619 --- -Muscles --- -Muscular dystrophy --- -Muscular dystrophies --- Dystrophy --- Genetic disorders --- Neuromuscular diseases --- Muscle --- Musculature --- Myodynamics --- Myology --- Musculoskeletal system --- Tissues --- Diseases of (undomesticated) animals. Animal pathology --- Clinical myology. Muscular system. Skeletal musculature --- Diseases of domesticated animals. Veterinary science --- -Animal models --- -Congresses --- -Genetic aspects --- Congresses. --- -Diseases of (undomesticated) animals. Animal pathology --- 619 Diseases of domesticated animals. Veterinary science --- 616.74 Clinical myology. Muscular system. Skeletal musculature --- 591.2 Diseases of (undomesticated) animals. Animal pathology --- -619 Diseases of domesticated animals. Veterinary science --- Muscular dystrophies --- Diseases&delete& --- Animal models&delete& --- Genetic aspects&delete& --- 619 Ziektes van gedomesticeerde dieren. Diergeneeskunde --- Ziektes van gedomesticeerde dieren. Diergeneeskunde --- Muscular dystrophy - Genetic aspects - Congresses --- Muscular dystrophy - Animal models - Congresses --- Muscles - Diseases - Genetic aspects - Congresses --- Muscles - Diseases - Animal models - Congresses