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Pathological anatomy and histology --- Pathology of the circulatory system --- Atherosclerosis --- Coronary heart disease --- Coronary Disease --- complications --- Atherosclerosis. --- Coronary heart disease. --- complications. --- Atherosclerosis - complications --- Coronary Disease - complications

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Vascular disease provides a clear example of the inherent and practical relationship between basic science and clinical medicine. Basic science underpins the rationale of treatment and potential future therapeutic approaches; problems in clinical management often direct new lines of laboratory research. Progress in treatment cannot continue without this close collaboration and this book has been designed to review this fascinating collaborative field of medical science. As part of this evolving collaboration, Vascular Complications of Human Disease: Mechanisms and Consequences reviews the study, pathogenesis, management and treatment of some of the most common vascular diseases. The book includes discussions of approaches to gene therapy and aspects of regenerative medicine plus also physiology and pathogenesis, surgical and pharmacologic treatment, and complications. Clinical specialists caring for patients with any form of vascular disease must clearly understand the basic scientific rationale for disease pathogenesis. This book presents a cohesive review of our current understanding of the most important areas of clinical science and medicine in vascular disease and identifies areas for research in the future. It will be a useful reference for basic and clinical scientists, and clinical specialists in vascular surgery, cardiology, angiology, neurology and any discipline in which the vascular system plays a fundamental part in the disease process.

Blood-vessels --- Diseases --- Diseases. --- Complications. --- Complications of diseases --- Disease complications --- Disease sequelae --- Sequelae of diseases --- Angiology --- Vascular diseases --- Complications and sequelae --- Sequelae --- Cardiology. --- Emerging infectious diseases. --- Internal medicine. --- Vascular Surgery. --- Infectious Diseases. --- Internal Medicine. --- Vascular surgery --- Medicine, Internal --- Medicine --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Heart --- Internal medicine --- Infectious diseases. --- Vascular surgery.

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Nervous System Diseases --- Collagen Diseases --- Collagen diseases --- Nervous system --- Collagénoses --- Système nerveux --- Diseases --- Maladies --- Neurologic Manifestations --- Disease --- complications --- Pathologie --- Immunologie --- Gastro-enterologie --- Neurologie --- Pulmonologie --- Hart- en vaatziekten --- Gastro-entérologie --- Pneumologie --- Maladies cardio-vasculaires --- Collagénoses --- Système nerveux --- Diseases. --- Nervous System Diseases. --- Collagen Diseases. --- Disease - complications

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The introduction of highly active antiretroviral therapy (HAART) has significantly improved the clinical outcome of HIV disease with increased survival rates. However, the introduction of HAART has generated a contrast in the cardiac manifestations of AIDS. In developed countries, we observed an approximate 30% reduction in the prevalence of HIV-associated cardiomyopathy, possibly related to a reduction of opportunistic infections and myocarditis. In developing countries, however, where the availability of HAART is limited and the pathogenic impact of nutritional factors is significant, we observed an approximate 32% increase in the prevalence of HIV-associated cardiomyopathy and a related high mortality rate from congestive heart failure. Additionally, some HAART regimens in developed countries, especially those including protease inhibitors, may cause an iatrogenic metabolic syndrome (HIV-lipodystrophy syndrome) that is associated with an increased risk of cardiovascular disease. At the same time, the relapse of some opportunistic infections, with possible myocardial involvement, in HIV-infected patients receiving HAART, in the context of the recently described immune reconstitution inflammatory syndrome, yielded an intriguing and complex profile of this dual aspect of cardiology in AIDS in the HAART era. In this new edition of Cardiovascular Disease in AIDS, new insights coming from basic and clinical research in the field of HIV-associated cardiovascular disease and antiretroviral therapy are reported, along with the clinical guidelines for a careful stratification of the cardiovascular risk and cardiovascular monitoring of HIV-infected patients receiving HAART. The authors offer a wide overview of the topic for specialists in cardiology and infectious diseases involved in the clinical management of HIV-infected patients.

Acquired Immunodeficiency Syndrome -- complications. --- AIDS (Disease) -- Complications. --- Antiretroviral agents. --- Antiretroviral Therapy, Highly Active -- adverse effects. --- Cardiovascular Diseases -- etiology. --- Cardiovascular system -- Diseases -- Etiology. --- HIV Infections -- complications. --- Diseases --- Drug Therapy, Combination --- Immunologic Deficiency Syndromes --- Slow Virus Diseases --- Sexually Transmitted Diseases, Viral --- Lentivirus Infections --- Virus Diseases --- Retroviridae Infections --- Immune System Diseases --- Sexually Transmitted Diseases --- Drug Therapy --- Therapeutics --- RNA Virus Infections --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Acquired Immunodeficiency Syndrome --- HIV Infections --- Antiretroviral Therapy, Highly Active --- Cardiovascular Diseases --- Medicine --- Health & Biological Sciences --- Clinical Immunology --- AIDS (Disease) --- Cardiovascular system --- Complications. --- Etiology. --- Circulatory system --- Vascular system --- Anti-retroviral agents --- Antiretroviral drugs --- Antiretrovirals --- Medicine. --- Internal medicine. --- Angiology. --- Cardiology. --- Infectious diseases. --- Medicine & Public Health. --- Infectious Diseases. --- Internal Medicine. --- Antiviral agents --- Blood --- Circulation --- Angiography. --- Emerging infectious diseases. --- Medicine, Internal --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Blood-vessels --- Diagnosis, Radioscopic --- Radiography, Medical --- Heart --- Internal medicine --- Radiography

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Chemokines and their receptors are being recognized as an integral component of the nervous system implicated in fundamental aspects of development and homeostasis, such as neurotransmission, proliferation, differentiation, and neuronal-glial communication. Thus, their involvement in HIV neuropathology goes far beyond the co-receptors role and entails complex interactions of the chemokine system with different cell types and other regulators of neuronal function. The major goal of this volume is to review these topics in order to highlight alterations of chemokine physiology that may contribute to neuroAIDS and other neuropathologies. This book will be of interest to neuroscientists, neurologists, virologists, pharmacologists, and students in these fields. About the Editor: Olimpia Meucci, MD, PhD is a Professor of Pharmacology and Physiology & Microbiology and Immunology at Drexel University College of Medicine in Philadelphia, PA. Since her seminal discovery about the regulation of neuronal signaling by chemokines, her research has primarily focused on the physio-pathological roles of this important class of neuroimmune modulators in the central nervous system and their involvement in neuroAIDS. These studies have significantly contributed to current understanding of the cellular and molecular mechanisms of HIV-related neuropathology including the interaction of the chemokine system with drug of abuse, namely opiates, which continues to be a major area of investigation in the Meucci lab.

AIDS (Disease) -- Complications -- Treatment. --- Chemokines -- Receptors. --- Chemokines. --- HIV infections -- Complications -- Treatment. --- Chemokines --- AIDS (Disease) --- HIV infections --- Nervous system --- Antigens, CD --- Cytokines --- Diseases --- Immunologic Deficiency Syndromes --- Inflammation Mediators --- Receptors, Cytokine --- Sexually Transmitted Diseases, Viral --- Biological Science Disciplines --- Slow Virus Diseases --- Receptors, G-Protein-Coupled --- Lentivirus Infections --- Chemotactic Factors --- Physiology --- Acquired Immunodeficiency Syndrome --- Nervous System Diseases --- HIV Infections --- Receptors, Chemokine --- Immune System Diseases --- Intercellular Signaling Peptides and Proteins --- Antigens, Differentiation --- Sexually Transmitted Diseases --- Biological Factors --- Natural Science Disciplines --- Retroviridae Infections --- Receptors, Cell Surface --- Receptors, Immunologic --- Virus Diseases --- Proteins --- Chemicals and Drugs --- Disciplines and Occupations --- Antigens, Surface --- RNA Virus Infections --- Peptides --- Membrane Proteins --- Biological Markers --- Amino Acids, Peptides, and Proteins --- Antigens --- Medicine --- Biology --- Microbiology & Immunology --- Neurology --- Health & Biological Sciences --- Receptors --- Complications --- Treatment --- Chemotherapy --- Receptors. --- Treatment. --- Chemotherapy. --- HIV (Viruses) infections --- HTLV-III infections --- HTLV-III-LAV infections --- Human T-lymphotropic virus III infections --- Acquired immune deficiency syndrome --- Acquired immunodeficiency syndrome --- Acquired immunological deficiency syndrome --- Chemotactic cytokines --- Inflammatory peptides --- Intercrines --- Medicine. --- Neurosciences. --- Pharmacology. --- Virology. --- Infectious diseases. --- Biomedicine. --- Pharmacology/Toxicology. --- Infectious Diseases. --- Organs (Anatomy) --- Neurosciences --- Lentivirus infections --- Sexually transmitted diseases --- Immunological deficiency syndromes --- Virus-induced immunosuppression --- Inflammation --- Mediators --- Medical virology. --- Toxicology. --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Medical microbiology --- Virology --- Virus diseases --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Toxicology --- Drug effects --- Medical pharmacology --- Drugs --- Pharmacy --- Microbiology --- Physiological effect