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Diphosphonates --- Diphosphonates --- Bones
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Osteoporosis is one of the most frequent chronical diseases which may cause serious fractures, a disease for which pharmaceutical companies have put on the market relatively safe and effective drugs often prescribed as first-line drugs, namely biophosphonates. A pharmacotherapy of which the long-term follow-up remains suboptimal due to the biopsychosocial factors inherent to each patient which the pharmacist in the therapeutic follow-up be also to detect in order to find a remedy. In this context of potential non-compliance, the pharmacist must be involved in a counseling of support with the patient. It is in this benevolent and personalize care that requires great human qualities that lies the interest of this work. What are the essential human skills needed to help the osteoporotic patient to express his or her feelings, to verbalize his or her difficulties in the follow-up of the treatment? What communication tools should be offered to help patients recognize the importance of their treatment and to get them used to it? These are essential points to avoid any negative repercussions on the heath of the patient, but also on the public finances of the health care. L'ostéoporose fait partie des maladies chroniques de plus en plus fréquentes aux conséquences fracturaires graves ; une maladie pour laquelle, les firmes pharmaceutiques ont mis sur le marché des médicaments efficaces, sûrs et souvent prescrits en première intention à savoir, les bisphosphonates. Une pharmacothérapie dont le suivi à long terme reste sous optimal en raison de facteurs biopsychosociaux inhérents à chaque patient que le pharmacien d'officine dans le cadre du suivi thérapeutique se doit de détecter en vue d'y remédier. Dans ce contexte de potentielle inobservance, il doit s'investir dans une démarche de soutien qu'est la relation d'aide. C'est dans cette prise en charge bienveillante et personnalisée exigeant de grandes qualités humaines qu'intervient l'intérêt de ce travail. Quelles sont les compétences relationnelles primordiales à mettre en œuvre pour aider le patient ostéoporotique à exprimer son ressenti, à verbaliser ses difficultés quant au suivi de son traitement ? Quels outils de communication proposer pour le rendre apte à reconnaître l'importance de son traitement et à l'apprivoiser ? Des questions essentielles pour éviter des répercussions négatives sur la santé du patient, mais aussi sur les finances publiques de soins de santé.
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Biophosphanates are agents that belong to the current pharmacological arsenal used for the prevention and the treatment of the various types of osteoporosis. Their mechanism of action is complex: their main effect, however, consists in the inhibition of osteoclastic bone resorption, consequently providing a decrease in the risk of bone fractures. Their use, whether in the form of per os pills or intravenous injections, has been reported as potential cause for severe side-effects such as atypical femoral fractures, osteonecrosis of the jaw, atrial fibrillation, and esophageal cancer. Some properties of the biphosphonates drugs can explain the occurrence of such events (i.e. their negative effects in bone renewal and the formation of collagen, their toxicity on oral and hut mucosa, their anti-angiogenic effect, and their pro-inflammatory action). However, follow-up studies are still necessary to estimate the situation on a more definitive way. In order to avoid an increase in the number of patients presenting with side-effects, health care professionals, both physicians and pharmacists, need to play a pro-active role in educating their patients about the potential risks and precautions, and provide the appropriate follow-up Les biphosphonates font partie de l’arsenal thérapeutique de la prévention et du traitement des différents types d’ostéoporose. Leur mécanisme d’action est complexe mais ils provoquent une inhibition de la résorption ostéoclastique et ils permettent ainsi une diminution du risque de fracture. Leur utilisation, qu’il s’agisse de comprimés per os ou d’injections intraveineuses, semble responsable de l’apparition d’effets indésirables sérieux : des fractures atypiques du fémur, d’ostéonécroses de la mâchoire, de fibrillations auriculaires et de cancers de l’œsophage. Certaines propriétés des biphosphonates permettraient d’expliquer le survenue de ces événements : leur effet négatif sur le remodelage osseux et sur la formation de collagène, leur toxicité pour les muqueuses, leur pouvoir anti-angiogénique et leur action pro-inflammatoire. Néanmoins, des études complémentaires sont encore nécessaires pour évaluer la situation de façon définitive. Afin d’éviter l’augmentation du nombre de cas d’effets indésirables, les professionnels de la santé, médecins et pharmaciens, doivent jouer un rôle proactif dans l’éducation du patient et assurer un suivi adéquat
Diphosphonates --- Osteoporosis --- Pharmaceutical Preparations
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This dissertation by Jahan Abtahi investigates the integration of metal implants in jaw bone, focusing on the use of bisphosphonates to enhance implant stability. The research explores the effects of bisphosphonate coatings on implant fixation and the prevention of osteonecrosis of the jaw (ONJ), a condition associated with bisphosphonate use. Through clinical and animal studies, the dissertation demonstrates improved implant stability and reduced bone loss with bisphosphonate-coated implants. It also develops animal models to study ONJ, highlighting the condition's link to bone exposure and bisphosphonate treatment. The findings suggest potential advancements in orthopedic and dental applications for improving bone-implant integration.
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This book is an essential handbook on bisphosphonates, the most widely used new class of drugs for osteoporosis therapy. It reviews basic physiology in addition to the indications and adverse reactions of these drugs. Bisphosphonates in Bone Disease, 4E, discusses the compounds' chemistry, mechanisms of action, and animal toxicology before presenting a clinical picture of the diseases treated by bisphosphonates. The book provides a table listing the trade names of the commercially available bisphosphonates, registered indications, and the available forms for various countries. The revis
Diphosphonates --- Bones --- Therapeutic use. --- Diseases --- Chemotherapy.
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Osteoporosis --- Diphosphonates --- drug therapy --- therapeutic use
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BONE RESORPTION --- DIPHOSPHONATES --- THERAPY --- THERAPEUTIC USE --- BONE RESORPTION --- DIPHOSPHONATES --- THERAPY --- THERAPEUTIC USE
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Bone Remodeling --- Osteitis Deformans --- Diphosphonates --- drug effects --- drug therapy --- pharmacokinetics
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Diphosphonates --- Fluid Therapy --- Hypercalcemia --- Neoplasms --- therapeutic use --- therapy --- complications
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